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Full-Text Articles in Other Medical Sciences
An Examination Of Chimpanzee Use In Human Cancer Research, Jarrod Bailey
An Examination Of Chimpanzee Use In Human Cancer Research, Jarrod Bailey
Laboratory Experiments Collection
Advocates of chimpanzee research claim the genetic similarity of humans and chimpanzees make them an indispensable research tool to combat human diseases. Given that cancer is a leading cause of human death worldwide, one might expect that if chimpanzees were needed for, or were productive in, cancer research, then they would have been widely used. This comprehensive literature analysis reveals that chimpanzees have scarcely been used in any form of cancer research, and that chimpanzee tumours are extremely rare and biologically different from human cancers. Often, chimpanzee citations described peripheral use of chimpanzee cells and genetic material in predominantly human …
From Traumatic Brain Injury To Posttraumatic Epilepsy: What Animal Models Tell Us About The Process And Treatment Options, Asla Pitkänen, Riikka J. Immonen, Olli H.J. Gröhn, Irina Kharatishvili
From Traumatic Brain Injury To Posttraumatic Epilepsy: What Animal Models Tell Us About The Process And Treatment Options, Asla Pitkänen, Riikka J. Immonen, Olli H.J. Gröhn, Irina Kharatishvili
Biomedicine and Animal Models in Research Collection
A large number of animal models of traumatic brain injury (TBI) are already available for studies on mechanisms and experimental treatments of TBI. Immediate and early seizures have been described in many of these models with focal or mixed type (both gray and white matter damage) injury. Recent long-term video-electroencephalography (EEG) monitoring studies have demonstrated that TBI produced by lateral fluid-percussion injury in rats results in the development of late seizures, that is, epilepsy. These animals develop hippocampal alterations that are well described in status epilepticus–induced spontaneous seizure models and human posttraumatic epilepsy (PTE). In addition, these rats have damage …