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Full-Text Articles in Other Medical Sciences
Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Experimentation Collection
Animal tests yield misleading results.
Animal Models Of Head Trauma, Ibolja Cernak
Animal Models Of Head Trauma, Ibolja Cernak
Biomedicine and Animal Models in Research Collection
Animal models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae underlying human head injury in an effort to identify potential neuroprotective therapies for developing and adult brains. The choice of experimental model depends upon both the research goal and underlying objectives. The intrinsic ability to study injuryinduced changes in behavior, physiology, metabolism, the blood/tissue interface, the blood brain barrier, and/or inflammatory- and immune-mediated responses, makes in vivo TBI models essential for neurotrauma research. Whereas human TBI is a highly complex multifactorial disorder, animal trauma models tend to replicate only single factors involved in the pathobiology …