Neurosciences Commons^™

Neuroprotective Functions Of Docosahexaenoic Acid And Epidermal Fatty Acid Binding Protein, Manuel Luis Montero

Loma Linda University Electronic Theses, Dissertations & Projects

Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition of necroptosis and promotion of autophagy do. DHA decreases the expression of HIF-1α and BNIP3 and rescues PA-induced cell death by inhibiting apoptosis and necroptosis. Besides DHA stimulates the mRNA expression, phosphorylation and conjugation of autophagy controlling proteins. Inhibiting autophagy during DHA treatment decreases its capacity …

Role Of Slit2 In Reducing Complications After Surgical Brain Injury, Prativa Sherchan

Loma Linda University Electronic Theses, Dissertations & Projects

Surgical brain injury (SBI) is the inadvertent injury to brain tissue at the perisurgical site which occurs due to neurosurgical maneuvers such as incision, retraction, and electrocoagulation that can result in post-operative complications. Blood brain barrier (BBB) disruption and neuroinflammation are major pathophysiological consequences after neurosurgical injury. Blood brain barrier dysfunction leads to increased influx of water and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that further potentiates brain edema and worsens post-operative neurological function. Activated resident immune cells and infiltrated peripheral immune cells release inflammatory mediators and promote oxidative stress and cell death …

Role Of Astrocyte Network In Edema After Juvenile Traumatic Brain Injury, Andrew Minoru Fukuda

Loma Linda University Electronic Theses, Dissertations & Projects

Juvenile traumatic brain injury (jTBI) is the leading cause of death and disability in young children and adolescents. Despite its lasting detrimental effects on the developing brain, no pharmacological treatment exists. One of the pathological hallmarks of jTBI is edema. Astrocytes play a key role in the edema process, and have been hypothesized that numerous astrocyte networks allow communication and propagation of edema and secondary injury spread. Two key astrocyte proteins are hypothesized to have a central role in the edema process: Aquaporin 4 (AQP4) and Connexin 43 (Cx43). AQP4 is expressed extensively in astrocyte endfeet, which surrounds the blood …

Humor's Effect On Short-Term Memory In Older Adults: An Innovative Wellness Paradigm, Gurinder Singh Bains

Loma Linda University Electronic Theses, Dissertations & Projects

Context: With ageing, the detrimental effects of stress can impair the ability to learn and sustain memory. Humor and the associated mirthful laughter can reduce stress by decreasing the hormone cortisol. Chronic release of cortisol can damage hippocampal neurons leading to impairment of learning and memory. Objectives: To examine the effect of watching a humor video on short term memory in older adults. Design: A randomized, controlled trial. Setting: Loma Linda University, Loma Linda, CA. Participants: 30 subjects: 20 normal healthy, older adults, 11 males and 9 females; 10 Type 2 Diabetic older adults, 6 males and 4 females. Intervention: …

Lateralization Of Emotion, Reaction Time, And Skin Conductance Responsiveness, Kimberley Erin Rose

Loma Linda University Electronic Theses, Dissertations & Projects

Bilateral presentations of brief (250 ms), unmasked emotional and neutral stimuli were examined in two experiments with primarily female samples. Reaction time and accuracy data were used to measure perception of emotion and skin conductance response (SCR) was used to measure experience of emotion. Both words and pictures were used to account for hemispheric differences in language and visuospatial dominance. Response time was faster to emotional pictures than words. Reaction time and speeded accuracy data did not support right hemisphere hypothesis (RHH) or valence hypothesis (VH) in the expected manner. Data suggested emotion caused greater interference under speeded conditions in …

Electromagnetic Differences In The Brain During Memory Retrieval, Warren Scott Merrifield

Loma Linda University Electronic Theses, Dissertations & Projects

The primary objectives for this experiment were to analyze the neuroanatomical correlates of autobiographical, episodic and semantic memory, use a different paradigm to promote episodic memory retrieval, and employ a different analysis technique to understand retrieval processes. Autobiographical and episodic memories are personal memories from the past. Autobiographical is more general (e.g. a street name of a house growing up) and episodic is more specific to time (e.g. 13th birthday party that took place on a street). For autobiographical and episodic memory retrieval operations, there is no general consensus as to the localization of function, but bilateral activation of the …

Iron Dysregulation And Inflammation In Alzheimer’S Disease, Shino D. Magaki

Loma Linda University Electronic Theses, Dissertations & Projects

Alzheimer’s disease (AD) is the most common form of senile dementia in the US and worldwide but the causes of its pathogenesis are currently unknown. In this study, we examined two processes that have been implicated in the early stages of AD and other forms of neurodegeneration, iron dysregulation and inflammation, both of which can promote the increased production of amyloid precursor protein (APP). We have measured different pools of brain iron in transgenic iron regulatory protein 2 knockout (IRP2-/-) mice in the early stages of neurodegeneration and in affected brain regions from AD patients at different stages of the …

Update - March 2000, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- National conference explores the future of faith-based health care
-- Ruth Macklin Judges Bioethical Relativism (Commentary)
-- Conditional Imortality and Cognitive Neuroscience
-- Clinical Ethics Consultation

Modulation Of Neutrophil Functions By Neurotransmitters Implicated In Stress, Chok Ping Wan

Loma Linda University Electronic Theses, Dissertations & Projects

Stress has long been implicated in immune modulation. People under chronic stress have no change in the circulating basal levels of catecholamines while plasma levels of neuropeptide Y (NPY) are significantly increased. Sympathetic nerve fibers with NPY have been found to innervate immune organs. It was hypothesized that NPY might be a mediator in immune modulation in people under chronic stress. Human neutrophils were used as a model to study the effects of NPY alone or together with norepinephrine on the immune system. We now report that NPY modulates oxidative burst (OB) triggered by zymosan in human neutrophils while it …

A Possible Genetic Defect In The Causes Of Brain Aneurysms, George Austin, Wouter Schievink, Delbert Dickson, Stephanie Richardson, Emily Hanford

The Dr. George M. Austin Neurology Research Collection

A Possible Genetic Defect in the Causes of Brain Aneurysms. George Austin, M.D, Wouter Schievink, M.D., Delbert Dickson, M.D., Stephanie Richardson, B.S., and Emily Handford, B.S. 1 pg. Handwritten note indicates presentation at The American Association of Neurological Surgeons, April 1995, Orland Florida.

A Genetic Defect In Brain Aneurysms, George Austin, Wouter Schievink, Delbert Dickson, Stephanie Richardson, Emily Hanford

The Dr. George M. Austin Neurology Research Collection

A Genetic Defect in Brain Aneurysms. George Austin, M.D., Woutler Schievink, M.D., Delbert Dickson, M.D., Stephanie Richardson, B.S. and Emily Hanford, B.S. 1 pg. Handwritten not indicates conference presentation, American College of Surgeons, Southern Chapter, January 20-22, 1995.

Increased Brain Aneurysm Wall Strain: A Further Hazard For Rupture, George M. Austin, Wouter Schievink, Delbert Dickson, Stephanie Richardson, Emily Hanford

The Dr. George M. Austin Neurology Research Collection

Increased Aneurysm Wall Strain: A Potential for Rupture. George M. Austin, M.D., Wouter Schievink, M.D., Delbert Dickson, M.D., Stephanie Richardson, B.S. August 12,1994. Portland, Oregon, 3 pg. See also previously presented version in additional files.

[George M. Austin Autobiography Drafts], George M. Austin, Society Of Neurological Surgeons Historian

The Dr. George M. Austin Neurology Research Collection

George M. Austin autobiography drafts.

1. Draft dated September 26, 1994.
2. “First Draft” dated September 21, 1994
3. Draft handwritten on lined yellow paper
4. Typed letter. To All members Society of Neurological Surgeons From Historian. Letter requests a biography and photograph.

Factors Altering Aneurysm Wall Strain, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Factors Altering Aneurysm Wall Strain. George M. Austin, M.D. Poster presentation. American Association of Neurological Surgeons, San Diego Convention Center. April 9-14, 1994. 1 pg.

Brain Aneurysms And Aging, G. M. Austin, W. Schievink, D. Dickson

The Dr. George M. Austin Neurology Research Collection

Brain Aneurysms and Aging. G. M. Austin, M.D., W. Schievink, M.D., and D. Dickson, M.D., 1994. Presentation manuscript. 1 pg.

A Genetic Basis For Brain Aneurysms, G. Austin, W. Schievink, D. Dickson, S. Richardson

The Dr. George M. Austin Neurology Research Collection

A Genetic Basis for Brain Aneurysms. Austin, G., Schievenk, W., Dickson, D., and Richardson, S. Brain Aneurysm Research Laboratory, Neuroscience Institute, U.C.S.B., Santa Barbara, CA. A handwritten note indicates that this is an abstract presented at the Biophysical Society, February 12-16, 1995. 2 pg.

Abstract: Genetic Changes In Brain Aneurysm Wall Protein, G. Austin, W. Schievink, D. Dickson, S. Harris, B. Blackbourne, S. Richardson

The Dr. George M. Austin Neurology Research Collection

Genetic Changes in Brain Aneurysm Wall Protein. G. Austin, W. Schievink, D. Dickson, S. Harris, B. Blackbourne, S. Richardson, Brain Aneurysm Research Laboratory, Neuroscience Institute, University of California at Santa Barbara, N.d. [c.1994?] Abstract.

Brain Aneurysms, Aneurysm Research Inst.

The Dr. George M. Austin Neurology Research Collection

“Brain Aneurysms”

Single sheet of paper describing brain aneurysms. Addressed at bottom: “Aneurysm Research Inst, 1187 Coast Village road, Suite 114, Santa Barbara, CA 93108.”

Bibliography, George M. Austin, 1993, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Bibliography, 202 entries, 15 pg., last entry dated 1993

[Project Proposal] Microscopic Analysis Of Intracranial Aneurysm Wall And Its Parent Arteries, George Austin, Steve Fisher

The Dr. George M. Austin Neurology Research Collection

Microscopic Analysis of Intracranial Aneurysm Wall and its Parent Arteries. George Austin, M.D., Steve Fisher, M.D., N.d. [1992 or later] Project proposal. 7 pg.

Bibliography, George M. Austin (1992), George M. Austin

The Dr. George M. Austin Neurology Research Collection

Bibliography, 169 entries 14 pg., last entry is for 1992

An Anatomic-Pathologic Investigation Of The Causes Of Growth And Rupture Of Intracranial Aneurysms, George Austin, Gary Ponto

The Dr. George M. Austin Neurology Research Collection

An Anatomic-Pathologic Investigation of the Causes of Growth and Rupture of Intracranial Aneurysms. George Austin, M.D. and Gray Ponto, M.D. Typewritten research proposal manuscript. 22 pg.

Neurological Problems Of Older Retired People, Lecture 9, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Neurological Problems of Older Retired People. George Austin. Lecture 9 (November 1989). 2 pg. With Handwritten lecture notes, 3 yellow lined sheets as additional files.

Intracranial Aneurysm-Early Diagnosis & Management, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Intracranial Aneurysm-Early Diagnosis & Management

Two lectures as follows:

Intracranial Aneurysm-Early Diagnosis & Management Before Major Rupture. George M. Austin, M.D., St. Francis Hospital, August 12, 1988. 1 pg. plus chart.

Early Diagnosis and Management of Intracranial Aneurysms Prior to Rupture. George M. Austin, M.D., Santa Ynez Hospital, August 23, 1988. 1 pg.

Anterior Communicating Artery Aneurysm And Vasospasm – A Computer Model [Poster Boards], G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Poster presentation boards for “Anterior Communicating Artery Aneurysm and Vasospasm – A Computer Model,” G. Austin and R. Gaskell – Storke [sic] Research Foundation, Santa Barbara, Ca. and Dept. of Neurosurgery, Univ. of S. Cal., L.A., 5 p.

Digital Computer Model Of An Intracranial Aneurysm, G. Austin, R. Gaskell

The Dr. George M. Austin Neurology Research Collection

Digital Computer Model of an Intracranial Aneurysm. G. Austin, R. Gaskell. Poster presentation. American Association of Neurologic Surgeons, April 8-12, 1984.

File includes Abstract, 1 pg; Presentation, 2 pg; Presentation draft, 3 pgs.

The Changes Of Cortical Blood Flow And Cortical Oxygen Tension In Focal Ischemia, K. Kaminoga, Y. Taguchi, G. Austin

The Dr. George M. Austin Neurology Research Collection

The Changes of Cortical Blood Flow and Cortical Oxygen Tension in Focal Ischemia. K. Kaminoga, M.D., Y. Taguchi, M.D., G. Austin. The Stroke Research Foundation and Department of Environmental Stress, UC-Santa Barbara, Ca. Presented at the Southern California Chapter American college of Surgeons, Santa Barbara, Calif. 28 January 1984. 2 pg.

[3 Cortical Blood Flow And Oxygenation Abstracts], Y. Taguchi, M. Kaminogo, G. Austin

The Dr. George M. Austin Neurology Research Collection

Three presentations stapled together:

The Changes of Cortical Blood Flow and Cortical Oxygen Tension in Focal Ischemia. M. Kaminoga, M.D., Y. Taguchi, G. Austin, M.D. Conference presentation. American College of Surgeon Annual Meeting, January 28, 1984. NOTE 2nd page of this abstract not present in this file. 2nd page is present in Individual presentation posted separately.

Effect of Hypoxia and Hyperoxia of NADH Redox State and Cortical PO₂ in the Rabbit. Y Taguchi, M.D.; M. Kaminogo, M.D.; G. Austin, M.D. Conference Presentation. Southern California Chapter, American College of Surgeons, Santa Barbara, Calif, January 28, 1984.

Autoregulation of Cortical …

Alteration Of Regional Blood Flow And Autoregulation Test In Patients With Vertebrobasilar Disease, Hiroaki Koga, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Alteration of Regional Blood Flow and Autoregulation Test in Patients with Vertebrobasilar Disease. Hiroaki Koga, M.D., George M. Austin, M.D. Conference presentation. International Symposium on Microsurgical Anastomoses for Cerebral Ischemia. September 1982. 9 pg.

Prevention And Treatment Of Stroke By Ec-Ic Bypass, George M. Austin

The Dr. George M. Austin Neurology Research Collection

Prevention and Treatment of Stroke by EC-IC Bypass. George Austin, M.D. 12 pg. Lecture given on three different dates with variations:

Thursday, Dec. 17, 1981, Cottage Hospital

Monday, Dec. 21, 1981, Santa Ynez Valley Hospital

Monday, Jan. 18, 1982, The Hospital of the Good Samaritan