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Musculoskeletal, Neural, and Ocular Physiology Commons™
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Full-Text Articles in Musculoskeletal, Neural, and Ocular Physiology
Artificial Intelligence Frameworks To Detect And Investigate The Pathophysiology Of Spaceflight Associated Neuro-Ocular Syndrome (Sans), Joshua Ong, Ethan Waisberg, Mouayad Masalkhi, Sharif Amit Kamran, Kemper Lowry, Prithul Sarker, Nasif Zaman, Phani Paladugu, Alireza Tavakkoli, Andrew G Lee
Artificial Intelligence Frameworks To Detect And Investigate The Pathophysiology Of Spaceflight Associated Neuro-Ocular Syndrome (Sans), Joshua Ong, Ethan Waisberg, Mouayad Masalkhi, Sharif Amit Kamran, Kemper Lowry, Prithul Sarker, Nasif Zaman, Phani Paladugu, Alireza Tavakkoli, Andrew G Lee
Student Papers, Posters & Projects
Spaceflight associated neuro-ocular syndrome (SANS) is a unique phenomenon that has been observed in astronauts who have undergone long-duration spaceflight (LDSF). The syndrome is characterized by distinct imaging and clinical findings including optic disc edema, hyperopic refractive shift, posterior globe flattening, and choroidal folds. SANS serves a large barrier to planetary spaceflight such as a mission to Mars and has been noted by the National Aeronautics and Space Administration (NASA) as a high risk based on its likelihood to occur and its severity to human health and mission performance. While it is a large barrier to future spaceflight, the underlying …
Mammalian And Invertebrate Models As Complementary Tools For Gaining Mechanistic Insight On Muscle Responses To Spaceflight, Amber M. Paul, Thomas Cahill, Henry Cope, Joseph J. Bass, Eliah G. Overbey, Rachel Gilbert
Mammalian And Invertebrate Models As Complementary Tools For Gaining Mechanistic Insight On Muscle Responses To Spaceflight, Amber M. Paul, Thomas Cahill, Henry Cope, Joseph J. Bass, Eliah G. Overbey, Rachel Gilbert
Publications
Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruit fly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals …