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Musculoskeletal, Neural, and Ocular Physiology Commons™

Open Access. Powered by Scholars. Published by Universities.®

Selected Works

2014

Articles 1 - 3 of 3

Full-Text Articles in Musculoskeletal, Neural, and Ocular Physiology

Motor Assessment Using The Nih Toolbox, David Reuben, Susan Magasi, Heather Mccreath, Richard Bohannon, Ying-Chih Wang, Deborah Bubela, William Rymer, Jennifer Beaumont, Rose Rine, Jin-Shei Lai, Richard Gershon Nov 2014

Motor Assessment Using The Nih Toolbox, David Reuben, Susan Magasi, Heather Mccreath, Richard Bohannon, Ying-Chih Wang, Deborah Bubela, William Rymer, Jennifer Beaumont, Rose Rine, Jin-Shei Lai, Richard Gershon

Rose Marie Rine P.T., Ph.D.

Motor function involves complex physiologic processes and requires the integration of multiple systems, including neuromuscular, musculoskeletal, and cardiopulmonary, and neural motor and sensory-perceptual systems. Motor-functional status is indicative of current physical health status, burden of disease, and long-term health outcomes, and is integrally related to daily functioning and quality of life. Given its importance to overall neurologic health and function, motor function was identified as a key domain for inclusion in the NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox). We engaged in a 3-stage developmental process to: 1) identify key subdomains and candidate measures for inclusion …

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Ampk Activation: A Therapeutic Target For Type 2 Diabetes?, Kimberly A. Coughlan, Rudy Valentine, Neil B. Ruderman, Asish K. Saha Jun 2014

Ampk Activation: A Therapeutic Target For Type 2 Diabetes?, Kimberly A. Coughlan, Rudy Valentine, Neil B. Ruderman, Asish K. Saha

Rudy Valentine

Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have T2D, and the International Diabetes Federation projects that this number will increase to nearly 600 million by 2035. There is a great need for more effective treatments for maintaining glucose homeostasis and improving insulin sensitivity. AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase whose activation elicits insulin-sensitizing
effects, making it an ideal therapeutic target for T2D. AMPK is an energy-sensing enzyme that is activated when cellular energy levels are low, and it signals …

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Acetaminophen Improves Protein Translational Signaling In Aged Skeletal Muscle, Miaozong Wu, Hua Liu, Jacqueline Fannin, Anjaiah Katta, Yeling Wang, Ravi Kumar Arvapalli, Satyanarayana Paturi, Sunil K. Karkala, Kevin M. Rice, Eric R. Blough Jan 2014

Acetaminophen Improves Protein Translational Signaling In Aged Skeletal Muscle, Miaozong Wu, Hua Liu, Jacqueline Fannin, Anjaiah Katta, Yeling Wang, Ravi Kumar Arvapalli, Satyanarayana Paturi, Sunil K. Karkala, Kevin M. Rice, Eric R. Blough

Ravi K. Arvapalli

Background: Age-related muscle atrophy is characterized by increased oxidative stress, diminished Akt enzymatic function, and reduced phosphorylation of the mammalian target of rapamycin (mTOR), which can be attenuated by chronic acetaminophen ingestion. Here we hypothesize that age-related impairments in Akt/ mTOR function are associated with reduced protein translational signaling, and that these changes, if present, can be attenuated by acetaminophen treatment. Results: Compared to 6- and 27-month old animals, the expression of the mTOR-complex proteins raptor and GbL and the phosphorylation of tuberin/TSC2 (Thr1462) were reduced in the soleus muscles of very aged rats (33 months old). These changes in …

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