Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aging (1)
- Artificial gravity (1)
- Astrogliosis (1)
- CNS (1)
- Cardiomyopathy (1)
-
- Central Nervous (1)
- Cord (1)
- Exitotoxicity (1)
- Falls (1)
- Free Radical (1)
- Glial (1)
- Glutamate (1)
- Heart failure (1)
- Injury (1)
- Microgravity (1)
- Na+-glucose cotransporter (1)
- Na+/Ca2+ exchanger (1)
- Na+/H+ exchanger (1)
- Na+/K+-ATPase (1)
- Nervous (1)
- Orthostatic intolerance (1)
- Primary injury (1)
- ROS (1)
- Research (1)
- Secondary injury (1)
- Spaceflight simulations (1)
- Spinal (1)
- Spinal Column (1)
- Spinal Cord (1)
- Spine (1)
Articles 1 - 4 of 4
Full-Text Articles in Medical Physiology
Myocyte [Na+]I Dysregulation In Heart Failure And Diabetic Cardiomyopathy, Sanda Despa
Myocyte [Na+]I Dysregulation In Heart Failure And Diabetic Cardiomyopathy, Sanda Despa
Pharmacology and Nutritional Sciences Faculty Publications
By controlling the function of various sarcolemmal and mitochondrial ion transporters, intracellular Na+ concentration ([Na+]i) regulates Ca2+ cycling, electrical activity, the matching of energy supply and demand, and oxidative stress in cardiac myocytes. Thus, maintenance of myocyte Na+ homeostasis is vital for preserving the electrical and contractile activity of the heart. [Na+]i is set by the balance between the passive Na+ entry through numerous pathways and the pumping of Na+ out of the cell by the Na+/K+-ATPase. This equilibrium is perturbed in heart failure, …
Artificial Gravity As A Countermeasure To The Cardiovascular Deconditioning Of Spaceflight: Gender Perspectives, Joyce M. Evans, Charles F. Knapp, Nandu Goswami
Artificial Gravity As A Countermeasure To The Cardiovascular Deconditioning Of Spaceflight: Gender Perspectives, Joyce M. Evans, Charles F. Knapp, Nandu Goswami
Biomedical Engineering Faculty Publications
Space flight-induced physiological deconditioning resulting from decreased gravitational input, decreased plasma volume, and disruption of regulatory mechanisms is a significant problem in returning astronauts as well as in normal aging. Here we review effects of a promising countermeasure on cardiovascular systems of healthy men and women undergoing Earth-based models of space-flight. This countermeasure is produced by a centrifuge and called artificial gravity (AG). Numerous studies have determined that AG improves orthostatic tolerance (as assessed by various protocols) of healthy ambulatory men, of men deconditioned by bed rest or by immersion (both wet and dry) and, in one case, following spaceflight. …
Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin
Senior Honors Theses
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …
Effects Of Load Carriage And Surface Inclination On Linear And Non-Linear Postural Variability, Rahul Soangra, Hema Bhatt, Ehsan Rashedi
Effects Of Load Carriage And Surface Inclination On Linear And Non-Linear Postural Variability, Rahul Soangra, Hema Bhatt, Ehsan Rashedi
Physical Therapy Faculty Articles and Research
Understanding of inclined-work-related risk of falls and developing novel practical engineering controls for reducing this risk of falls among hilly working population remains in high demand. Standing on sloped surfaces provides a unique environment for examining the biomechanics and neural control of standing. The present investigation examined the variability of postural signals when standing on inclined surfaces and with load carriages by linear and nonlinear analysis. The purpose of this study was to determine if the sloped surface deteriorated in postural stability among healthy individuals with two distinctive kinds of load carriage methods head versus posterior load carriage. We also …