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Medical Biomathematics and Biometrics Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Medical Biomathematics and Biometrics
Computer-Aided Drug Discovery For Helicobacter Pylori, Nicole Ann Vita
Computer-Aided Drug Discovery For Helicobacter Pylori, Nicole Ann Vita
Theses and Dissertations (ETD)
Helicobacter pylori is a high-priority drug-resistant pathogen and is currently the only bacteria considered to be a class I carcinogen and there is a critical need to identify novel chemical matter to treat H. pylori infections. Hp is responsible for greater than 60% of gastric cancer related deaths and 89% of all gastric cancer morbidities. In a previous study, our lab identified novel Hp thienopyrmidine inhibitors that target respiratory complex I, an essential enzyme in respiration. Respiratory complex I is a large asymmetric multidomain and membrane bound enzyme and due to these innate features, it is not practical for biophysical …
A Two-Layer Continuous-Capillary Oxygen Transport Model: Development And Application To Blood Flow Regulation In Resting Skeletal Muscle., Keith C. Afas
Electronic Thesis and Dissertation Repository
In skeletal muscle (SM), the microcirculation distributes blood flow to capillary networks to meet local oxygen (O2) demand. Experiments using intra-vital video microscopy (IVVM) have quantified blood flow and O2 supply in capillary networks, and using an O2 exchange chamber have measured local changes in blood flow believed due to O2-dependent regulation. However, IVVM is unable to simultaneously measure capillary O2 supply and SM O2 content, implying the need for theoretical models to understand how flow regulation and SM oxygenation interact. In this thesis, a novel blood-tissue O2 transport model using …
Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte
Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte
Theses and Dissertations
Inverse modeling in cardiovascular medicine is a collection of methodologies that can provide non-invasive patient-specific estimations of clinical risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs.
Herein, three different phase contrast magnetic resonance imaging (MRI) modalities were implemented as input data, displacement encoding with stimulated echoes (DENSE MRI) applied, and time-resolved velocity encoding phase-contrast MRI, in 1D and 3D, applied to pulmonary artery (PA) hemodynamics.
A model to account for the effect of periaortic interactions due to static and dynamic structures …