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Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill
Mathematical Model Of Placental Oxygen And Carbon Dioxide Exchange, Ester P. Hill
Loma Linda University Electronic Theses, Dissertations & Projects
This model of placental CO2 and O2 exchange calculates the time course of changes in PCO2, [HCO3-], and [H+] in each of four "compartments" of placental exchange vessels: maternal erythrocytes, maternal plasma, fetal plasma and fetal erythrocytes. The changes in hemoglobin-bound CO2 (carbamate) and oxyhemoglobin contents within the erythrocytes are also calculated, permitting consideration of the Haldane and Bohr effects. Equations were written to represent one-dimensional steady state CO2 and O2 diffusion between concurrent maternal and fetal capillaries and the subsequent hydration, carbamino and oxyhemoglobin reactions. The equations …