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Antioxidant Enzyme Gene Transfer For Ischemic Diseases, Jian Wu

jian duan wu

1. Adv Drug Deliv Rev. 2009 Apr 28;61(4):351-63. Epub 2009 Feb 20. Antioxidant enzyme gene transfer for ischemic diseases. Wu J, Hecker JG, Chiamvimonvat N. Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA. jdwu@ucdavis.edu The balance of redox is pivotal for normal function and integrity of tissues. Ischemic insults occur as results of a variety of conditions, leading to an accumulation of reactive oxygen species (ROS) and an imbalanced redox status in the tissues. The oxidant stress may activate signaling mechanisms provoking more toxic events, and eventually cause tissue damage. Therefore, …