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Articles 1 - 5 of 5
Full-Text Articles in Medical Sciences
Development Of Oral Vaccines Against Lyme Disease, Rita Raquel Dos Anjos De Carvalho E Melo
Development Of Oral Vaccines Against Lyme Disease, Rita Raquel Dos Anjos De Carvalho E Melo
Theses and Dissertations (ETD)
Lyme Disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. If left untreated, it can lead to permanent damage to the nervous and musculoskeletal systems. In some cases, patients that receive the recommended antibiotic therapy develop a debilitating health condition associated with substantial health care costs. Despite current preventive measures, the incidence and the geographic distribution of Lyme Disease continues to increase. Recent estimates from CDC suggest that the true number of cases of Lyme Disease in the US is approximately 300,000 per year. Yet, there is currently no vaccine …
Borrelia Burgdorferi Reva Significantly Affects Pathogenicity And Host Response In The Mouse Model Of Lyme Disease, Rebecca Byram, Robert A. Gaultney, Angela M. Floden, Christopher Hellekson, Brandee L. Stone, Amy Bowman, Brian Stevenson, Barbara J. B. Johnson, Catherine A. Brissette
Borrelia Burgdorferi Reva Significantly Affects Pathogenicity And Host Response In The Mouse Model Of Lyme Disease, Rebecca Byram, Robert A. Gaultney, Angela M. Floden, Christopher Hellekson, Brandee L. Stone, Amy Bowman, Brian Stevenson, Barbara J. B. Johnson, Catherine A. Brissette
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The Lyme disease spirochete, Borrelia burgdorferi, expresses RevA and numerous outer surface lipoproteins during mammalian infection. As an adhesin that promotes bacterial interaction with fibronectin, RevA is poised to interact with the extracellular matrix of the host. To further define the role(s) of RevA during mammalian infection, we created a mutant that is unable to produce RevA. The mutant was still infectious to mice, although it was significantly less well able to infect cardiac tissues. Complementation of the mutant with a wild-type revA gene restored heart infectivity to wild-type levels. Additionally, revA mutants led to increased evidence of arthritis, …
Lyme Disease: A Tick’S Risky Bite, Jana Keller
Lyme Disease: A Tick’S Risky Bite, Jana Keller
Nursing Student Class Projects (Formerly MSN)
Lyme Disease is a bacterial infection transmitted primarily by the deer tick and is commonly seen in the United States. It is an infectious disease caused by the bacterium Borrelia burgdorferi, which is a spirochete (Pearson, 2014). Lyme disease’s prevalence is confirmed by the Centers for Disease Control and Preventions whom estimates that 30,000 people per year are diagnosed with Lyme disease in the Unites States (Moore, 2015). It is imperative that primary health care workers (such as Nurse Practitioners) are familiar with this disease and the early signs and symptoms. If early signs and symptoms go unnoticed or misdiagnosed …
Lyme Disease, Jared Hostetler
Lyme Disease, Jared Hostetler
Nursing Student Class Projects (Formerly MSN)
Lyme disease is the most common vector borne illness found in the United States. Each year 30,000 people are diagnosed with the disease, with many more cases going unreported (Centers for Disease Control and Prevention, 2015). The vector responsible for spreading the disease is the deer tick. The infection itself is caused by the spirochete Borrelia burgdorferi. This bacteria is transmitted through the saliva from the bite of a deer tick. Diagnosis can be challenging due to the fact that multiple systems of the body can be affected with different severities. Early diagnosis and treatment is critical in the prevention …
Apparent Role For Borrelia Burgdorferi Luxs During Mammalian Infection, William K. Arnold, Christina R. Savage, Alyssa D. Antonicello, Brian Stevenson
Apparent Role For Borrelia Burgdorferi Luxs During Mammalian Infection, William K. Arnold, Christina R. Savage, Alyssa D. Antonicello, Brian Stevenson
Microbiology, Immunology, and Molecular Genetics Faculty Publications
The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-associated proteins. luxS mutants, which are unable to produce AI-2, exhibit altered production of several proteins. B. burgdorferi cannot utilize the other product of LuxS, homocysteine, indicating that phenotypes of luxS mutants are not due to the absence of that molecule. Although a previous study found that a luxS mutant was capable of infecting mice, a critical caveat to those results is that bacterial …