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Articles 1 - 3 of 3
Full-Text Articles in Medical Sciences
Glutamatergic Plasticity In Medial Prefrontal Cortex And Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration, Behnam Ghasemzadeh, Preethi Vasudevan, Chad Giles, Anthony Purgianto, Chad Seubert, John R. Mantsch
Glutamatergic Plasticity In Medial Prefrontal Cortex And Ventral Tegmental Area Following Extended-Access Cocaine Self-Administration, Behnam Ghasemzadeh, Preethi Vasudevan, Chad Giles, Anthony Purgianto, Chad Seubert, John R. Mantsch
Biomedical Sciences Faculty Research and Publications
Glutamate signaling in prefrontal cortex and ventral tegmental area plays an important role in the molecular and behavioral plasticity associated with addiction to drugs of abuse. The current study investigated the expression and postsynaptic density redistribution of glutamate receptors and synaptic scaffolding proteins in dorsomedial and ventromedial prefrontal cortex and ventral tegmental area after cocaine self-administration. After 14 days of extended-access (6 h/day) cocaine self-administration, rats were exposed to one of three withdrawal regimen for 10 days. Animals either stayed in home cages (Home), returned to self-administration boxes with the levers withdrawn (Box), or underwent extinction training (Extinction). Extinction training …
Frazzled And Abelson Interact To Regulate The Actin Cytoskeleton In Drosophila, Bridget Elsa Varughese
Frazzled And Abelson Interact To Regulate The Actin Cytoskeleton In Drosophila, Bridget Elsa Varughese
Wayne State University Dissertations
Guidance receptors such as Frazzled affect cell shape and motility by directly or indirectly modulating the cytoskeleton. Fra is particularly needed for the formation of the posterior commissures in a developing Drosophila embryo. The cytoplasmic tyrosine kinase, Abelson Kinase (Abl) enhances the loss of commissures observed in fra mutant. Abl physically interacts with Frazzled to help guide commissural axons across the midline. Furthermore, the loss of commissural axons is only seen when the actin dynamics are perturbed. Abl is also known to regulate actin-dependent processes underlying formation of filopodia, microspikes and membrane ruffles. So, we established a Drosophila S2 cell …
Myosin Ii In Hippocampal Synapses: Regulation Of Synaptic Plasticity, Strength And Actin Dynamics By Two Distinct Isoforms, Maria Dolores Rubio
Myosin Ii In Hippocampal Synapses: Regulation Of Synaptic Plasticity, Strength And Actin Dynamics By Two Distinct Isoforms, Maria Dolores Rubio
All ETDs from UAB
Cytoskeletal actin filaments underlie dendritic spine plasticity, critical for several forms of learning and memory. Therefore, understanding the mechanisms that regulate actin dynamics is essential to elucidate memory formation pathways. Myosins, a superfamily of actin binding proteins, have emerged as candidates for regulation of actin dynamics in the brain. Several myosin class II isoforms have been identified in brain, but their individual contribution to synaptic activity is still unknown. Based on the finding that myosin IIB regulates actin polymerization in the growth cone of developing neurons and that it is necessary for maintenance of dendritic spine structure, I hypothesized that …