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Full-Text Articles in Medical Sciences

Oral Dosages Of The Nsaid Aspirin Decreased The Growth Rate Of Species Found In The Human Gut Microbiome Including Akkermansia Muciniphila, Bacteroides Fragilis, Clostridium Sordellii, And Clostridium Difficile, Wyatt H. Greenbaum, Garrett J. Greenbaum, Anna Spiezio Sep 2023

Oral Dosages Of The Nsaid Aspirin Decreased The Growth Rate Of Species Found In The Human Gut Microbiome Including Akkermansia Muciniphila, Bacteroides Fragilis, Clostridium Sordellii, And Clostridium Difficile, Wyatt H. Greenbaum, Garrett J. Greenbaum, Anna Spiezio

PANDION: The Osprey Journal of Research and Ideas

Over past few decades, new insight has been revealed in the scientific community about the importance of the human gut microbiome relating to general health. It is known that imbalances in the species that reside in the human gut can cause organism-wide problems in humans. When prescribing or injecting oral medications, the thought of the downstream effects on the gut microbiome are not always considered. By exposing known healthy members of the gut; Akkermansia muciniphila, Bacteroides fragilis, Clostridium sordellii, and Clostridium difficile to the Aspirin, this study attempted to provide insight into the effects of the drug on bacterial growth. …


The Expression Of Acat1 In Oral Squamous Cell Carcinoma And The Adjacent Pre-Tumour Tissue, Hadis Firouzpour, Seyed Mohammad Shokrolahi, Ekaterina Bourova-Flin, Samira Derakhshan, Zahra Shahsavari, Abbas Karimi, Hassan Mir Mohammad Sadeghi, Afsaneh Goudarzi Nov 2022

The Expression Of Acat1 In Oral Squamous Cell Carcinoma And The Adjacent Pre-Tumour Tissue, Hadis Firouzpour, Seyed Mohammad Shokrolahi, Ekaterina Bourova-Flin, Samira Derakhshan, Zahra Shahsavari, Abbas Karimi, Hassan Mir Mohammad Sadeghi, Afsaneh Goudarzi

BioMedicine

Background: Altered acetyl CoA acetyltransferase 1 (ACAT1) expression has been reported in diverse cancers. However, the expression of ACAT1 and its prognostic value in oral squamous cell carcinoma (OSCC) has remained unexplored. Materials and methods: In this study, the expression of ACAT1 was analysed by immunohistochemistry (IHC) in 61 OSCC patients and compared between OSCC and adjacent pre-tumour tissue of 21 patients. Results: The expression of ACAT1 in OSCC tumours is heterogeneous between patients. More specifically, 52.38% of the patients show low expression of ACAT1 in both tumour and adjacent pre-tumour tissues, 9.52% of the patients show high expression of …