Medical Sciences Commons^™

Caregiver Perspectives On The Daily Function Of People Living With Hnrnph2-Related Neurodevelopmental Disorder: Developing A Conceptual Model, Rachel Salazar

Seton Hall University Dissertations and Theses (ETDs)

Introduction: Neurodevelopmental disorders are a group of conditions that start in childhood and lead to impairments in functioning. HNRNPH2-related neurodevelopmental disorder is an ultra-rare disorder in which individuals present with cognitive, behavioral, language and motor function impairments that often leads to reliance on their caregivers. Existing conceptual models of neurodevelopment are not specific to this ultra rare disorder and do not highlight the caregiver impact of living with HNRNPH2-related neurodevelopmental disorder.

Purpose: The purpose of this study is to understand the caregiver perspective on the everyday functioning of people living with HNRNPH2-related neurodevelopmental disorder to generate a …

Exploring The Relationship Between Nurse Supervisor’S Servant Leadership Behavior And Nursing Employee’S Self-Assessment Of Engagement And Burnout In Nigeria, Michael Otuwurunne

Seton Hall University Dissertations and Theses (ETDs)

Burnout is a problem among workers in Nigeria, especially among nurses (Ozumba, & Alabere, 2019). This study examined whether there was a significant relationship between the employee perception of the servant leadership behaviors of the nurse supervisor and the employee’s self-rating of burnout: exhaustion and disengagement, and servant leadership behaviors of the nurse supervisor, and engagement: vigor, dedication, and absorption. Exhaustion refers to an intensive physical, affective, and cognitive strain while disengagement refers to the distancing of oneself from one’s work, and experiencing negative attitudes toward the work object, work content, or one’s work in general (Demerouti et al., 2001). …

The Impact Of High Intensity Interval Training On Neurogenesis And Angiogenesis In The Dentate Gyrus, Darrin Lenhart

Seton Hall University Dissertations and Theses (ETDs)

BACKGROUND: Exercise is associated with improved neuronal health and longevity, synaptic plasticity, cerebral blood volume, overall brain volume, and neurogenesis which collectively may have the power to forestall neurodegenerative disease.

PURPOSE: This study aims to explore the impact of high intensity interval training on individuals with mild cognitive impairment using a range of cognitive, physiological, and biomechanical measures. Specifically, this study seeks to assess the impact of high intensity interval training on neurogenesis and angiogenesis in the dentate gyrus of individuals with mild cognitive impairment versus healthy age-matched controls, as assessed by urinalysis of BDNF levels, performance on the Rey …

Clinically Relevant Dosage Of Vancomycin Does Not Negatively Impact Periosteum Derived Osteoblast Precursor Cellular Functions, Alexis Hernandez

Seton Hall University Dissertations and Theses (ETDs)

Surgical site infections (SSI) can develop post-operatively and carry significant clinical and financial implications. SSI can carry a cost of up to $30,000 per case, as well as an estimated 6 day longer hospitalization. Patients with Type II Diabetes (DM) have an increased susceptibility to infection and suffer from poor bone healing overall. Therefore, diabetic patients who have undergone orthopedic surgery risk both an increased chance of developing an SSI as well as suboptimal bone healing. Vancomycin and other antibiotics have traditionally been used prophylactically to prevent infection, however the effect of vancomycin on bone healing in a diabetic population …

Cancer-Targeting Immunostimulatory Peptides As An Immunotherapeutic Approach To Cancer, Rachel Montel

Seton Hall University Dissertations and Theses (ETDs)

This dissertation reports the synthesis and biological applications of bifunctional trimeric peptides with B7H6-derived NKp30 binding motifs that serve to activate an immunocytotoxic response in natural killer cells and a GRP78-binding motif that can target tumors that express surface GRP78. In this manner the cancer-targeting immunostimulatory peptides are anticipated to directly bind and activate effector NK92-MI cells while also recognizing and binding to target A549 tumor cells to facilitate NK cell-dependent immunocytotoxicity of the targeted tumors. The NKp30 binding peptide motifs are derived from the tumor associated B7H6 antigen that is often downregulated or shed from the surface of tumors …

Adults’ Knowledge And Beliefs Surrounding Obstructive Sleep Apnea, Mazen Homoud

Seton Hall University Dissertations and Theses (ETDs)

Undiagnosed individuals with signs and symptoms of obstructive sleep apnea (OSA) are at higher risk of severe health complications than healthy individuals, and they pose a huge economic burden on society as well. Some scholars reported the lack of public knowledge of OSA as a major contributor to this phenomenon. However, there is a lack of information about assessing public knowledge and health belief of OSA and its nature across the risk level of having OSA.

Two self-reporting questioners were used in this mixed method study, a PI developed survey, the Obstructive Sleep Apnea Knowledge and Belief (OSA-KAB) © was …

The Intra-Rater Reliability Of The Clavicular Jump Test (Cjt), Thomas Koc

Seton Hall University Dissertations and Theses (ETDs)

Background: Shoulder pain is the third most common musculoskeletal complaint in today’s society. Approximately 50% of patients with shoulder pain seek medical attention, which includes physical therapy. A thorough understanding of the anatomy of the shoulder, including its fascial attachments, its biomechanics, and functional relationship to nearby spinal regions is crucial for successful rehabilitation diagnostics and treatment interventions. Purpose: The purpose of this study is to determine the intra-rater reliability of the Clavicular Jump Test (CJT). Methods: This study is a quasi-experimental, one-group pretest-posttest (repeated measures), and correlation design. A total of 96 subjects (47 males and 49 females) volunteered …

The Modified-Emory Functional Ambulation Profile: Convergent Validity In 5-11 Year Olds, Cheryl Anne Enslee

Seton Hall University Dissertations and Theses (ETDs)

Background The Patient Protection and Affordable Care Act of 2010 and the Middle Class Tax Relief and Job Creation Act of 2012 mandate patient centered, objective functional outcome reporting tied directly to limitations in mobility related to activity and participation in daily life (House of Representatives, 2009). These mandates apply to all persons, including children receiving therapy-based services. Literature on outcome measures in children has focused almost exclusively on capacity-based assessments that generally lack robust environmental context or demonstrate issues with objectivity. While constructs of the modified-Emory Functional Ambulation Profile (m-EFAP), a quantitative, objective outcome measure of functional mobility, support …

Rnai Nanotechnology: A Platform For Sirna Screening And Cancer Gene Therapy, Mayurbhai Ravikant Patel

Seton Hall University Dissertations and Theses (ETDs)

Over the past two decades, advances in RNA structural biology have improved our understanding of the structures and folding properties of naturally occurring RNAs. RNA sequences and structures participate in many specific biological functions, such as those performed by messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), micro RNA (miRNA), short-interfering RNA (siRNA), small nuclear RNA (snRNA) and many others. The noncoding RNAs, such as siRNA, do not express proteins but have been utilized in a wide range of applications, including RNA interference (RNAi) and the regulation of mRNA expression. These important biological functions have been implemented in gene …

Functional Analysis Of The Molluscum Contagiosum Virus Mc160 Death Effector Domain-Containing Protein Rxdl Motif, Sarah Weber

Seton Hall University Dissertations and Theses (ETDs)

The Molluscum contagiosum virus (MCV) is a member of the Poxviridae family that causes benign skin lesions. MCV lesions persist on average for 8-12 months in otherwise healthy individuals. MCV lesions are characterized by reduced inflammation. The persistence and reduction of inflammation at the site of MCV lesions have been attributed to MCV immune evasion genes. MCV encodes two death effector domain (DED) containing proteins, MC159 and MC160. DEDs are found in cellular proteins such as FADD and procaspase-8. These cellular proteins are involved in several innate immune responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and …

Antibacterial Evaluation Of Polygonum Multiflorum, Andy S. Demianicz

Seton Hall University Dissertations and Theses (ETDs)

Polygonum multiflorum, commonly known as Chinese Knotweed, is a tonic herb primarily used to enhance bodily functions. Recently, it has been shown to contain strong antioxidant, antibacterial and antiviral activity. The extract from the roots of Chinese Knotweed was used to assess its antibacterial properties against a broad spectrum of bacterial species, including 5 Gram-positive (B. cereus, B. megaterium, S. epidermidis, S. mutans and S. pyogenes) and 4 Gram-negative (E. aerogenes, E. coli, P. vulgaris and P. aeruginosa). Microtiter assays were carried out to evaluate the antibacterial activity of Chinese Knotweed at 0.5%, 1%, 1.5% and 2.5% concentrations in order …

Effect Of Chinese Knotweed Extract On Hsv-1 Infection Of Vero Cells, Derek J. Prince

Seton Hall University Dissertations and Theses (ETDs)

HSV-1 is an opportunistic virus responsible for infecting the majority of the global population. The ability of this virus to strategically alternate between lytic and latent states has made the development of effective treatments challenging. Polygonum multiflorum (Chinese Knotweed, CK) is a perennial plant local to the south central regions of China. The thunb (root) constituents of this compound have been used in traditional Chinese medicines to treat a broad range of illnesses for centuries. In the present study, CK root extracts were evaluated for potential anti-HSV-1 activity. Cytopathic effect (CPE) monitoring studies indicate that Vero cells infected with HSV-1 …

Effect Of Dual Tasking On Walking Over Even And Uneven Surfaces In Functionally Independent Community Older Adults, Olajide L. Kolawole

Seton Hall University Dissertations and Theses (ETDs)

While several studies have reported a decrement in performance by older adults while walking and concurrently performing a dual task on even surfaces, to date the effects of dual tasking while walking on uneven surfaces commonly found in the community has received less attention. Thus, we sought to test the hypothesis that an incremental decrement in gait parameters will be observed, when walking on an uneven versus an even surface and furthermore, that this decrement would be dependent upon the concurrent performance of a secondary cognitive and/or motor task in functionally independent-living-community older adults.

Dynamic Gait Index assessed the subject’s …

Activation And Suppression Of The Innate Immune System: Effects On Alcohol Intake, Marjorie Levinstein

Seton Hall University Dissertations and Theses (ETDs)

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Kinematic Analysis Of Head/Neck Movement Associated With Lacrosse Helmet Facemask Removal, Richard J. Boergers

Seton Hall University Dissertations and Theses (ETDs)

No abstract provided.

The Effects Of Traditional Strengthening Exercises Versus Functional Task Training On Pain, Strength, And Functional Mobility In The 45-65 Year Old Adult With Knee Osteoarthritis, Christine M. Stutz-Doyle

Seton Hall University Dissertations and Theses (ETDs)

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Somatostatin Regulates Intracellular Signaling In Human Bronchial Smooth Muscle Cells, Michael J. Alfonzo

Seton Hall University Dissertations and Theses (ETDs)

Somatostatin (somatotropin release inhibitory factor; SRIF), is an endogenous peptide family that controls cellular secretion and proliferation. While SRIF's cognate receptors and associated actions have been clearly identified in a range of tissues, such as the endocrine, gastrointestinal and immune systems, a role in human lung physiology remains unknown. Using primary human bronchial smooth muscle cells (hBSMC) as a model for studying SRIF's actions, we have investigated whether SRIF receptors are present and functional in human bronchial smooth muscle. Reverse transcriptase- polymerase chain reaction (RT-PCR) analysis ofhBSMC total mRNA demonstrated the presence of the sst, receptor subtype, providing a molecular …