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Articles 1 - 30 of 295
Full-Text Articles in Medical Sciences
Circulating Tnf-Like Protein 1a (Tl1a) Is Elevated Early In Rheumatoid Arthritis And Depends On Tnf, Y. Song, I. A. Choi, F. Meylan, M. K. Demoruelle, T. Farley, A. C. Richard, E. Hawley, J. Botson, P. Gregersen, R. M. Siegel, +19 Additional Authors
Circulating Tnf-Like Protein 1a (Tl1a) Is Elevated Early In Rheumatoid Arthritis And Depends On Tnf, Y. Song, I. A. Choi, F. Meylan, M. K. Demoruelle, T. Farley, A. C. Richard, E. Hawley, J. Botson, P. Gregersen, R. M. Siegel, +19 Additional Authors
Journal Articles
No abstract provided.
Allele-Specific Expression Changes Dynamically During T Cell Activation In Hla And Other Autoimmune Loci, M. Gutierrez-Arcelus, Y. Baglaenko, J. Arora, S. Hannes, Y. Luo, T. Amariuta, N. Teslovich, D. A. Rao, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors
Allele-Specific Expression Changes Dynamically During T Cell Activation In Hla And Other Autoimmune Loci, M. Gutierrez-Arcelus, Y. Baglaenko, J. Arora, S. Hannes, Y. Luo, T. Amariuta, N. Teslovich, D. A. Rao, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors
Journal Articles
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1–3. Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimmunity4,5. Here, we characterized the dynamics of genetic regulatory effects at eight time points during memory CD4+ T cell activation with high-depth RNA-seq in healthy individuals. We discovered widespread, dynamic allele-specific expression across the genome, where the balance of alleles changes over time. These genes were enriched fourfold within autoimmune loci. …
Expression Of Concern: Redox Modification Of Cysteine Residues Regulates The Cytokine Activity Of High Mobility Group Box-1 (Hmgb1) (Molecular Medicine (2012) 18 (250-259) Doi: 10.2119/Molmed.2011.00389), H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M. E. Bianchi, Y. Al-Abed, U. Andersson, K. J. Tracey, D. J. Antoine
Expression Of Concern: Redox Modification Of Cysteine Residues Regulates The Cytokine Activity Of High Mobility Group Box-1 (Hmgb1) (Molecular Medicine (2012) 18 (250-259) Doi: 10.2119/Molmed.2011.00389), H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M. E. Bianchi, Y. Al-Abed, U. Andersson, K. J. Tracey, D. J. Antoine
Journal Articles
© The Author(s). 2020. The Editors-in-Chief would like to alert readers that this article (Yang et al. 2012) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass spectrometrygenerated results regarding acetylated and redox-modified HMGB1. Appropriate editorial action will be taken once the investigation is concluded. Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, and Kevin J. Tracey agree to this editorial expression of concern. Daniel J. Antoine has not responded to any …
Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, X. Shen, S. Ma, P. Vemuri, G. Simon, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack, P. Davies, V. Shibley, +90 Additional Authors
Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, X. Shen, S. Ma, P. Vemuri, G. Simon, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack, P. Davies, V. Shibley, +90 Additional Authors
Journal Articles
© 2020, The Author(s). Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately discover known causal relationships. We used Alzheimer’s disease (AD), a complex progressive disease, as a model because the well-established evidence provides a “gold-standard” causal graph for evaluation. We evaluated …
Celebrating 20 Years Of Ighv Mutation Analysis In Cll., N. Chiorazzi, F. K. Stevenson
Celebrating 20 Years Of Ighv Mutation Analysis In Cll., N. Chiorazzi, F. K. Stevenson
Journal Articles
The division of CLL into 2 broad subsets with highly significant differences in clinical behavior was reported in 2 landmark papers in Blood in 1999.1,2 The simple analysis of the mutational status of the IGV regions provided both a prognostic indicator and an insight into the cellular origins. Derivation from B cells with very low or no IGV mutations generally leads to a more aggressive disease course than derivation from B cells with higher levels. This finding focused attention on surface Ig (sIg), the major B-cell receptor, and revealed dynamic antigen engagement in vivo as a tumor driver. It has …
Key Role Of Mif-Related Neuroinflammation In Neurodegeneration And Cognitive Impairment In Alzheimer's Disease, E. Nasiri, R. Sankowski, H. Dietrich, A. Oikonomidi, P. T. Huerta, J. Popp, Y. Al-Abed, M. Bacher
Key Role Of Mif-Related Neuroinflammation In Neurodegeneration And Cognitive Impairment In Alzheimer's Disease, E. Nasiri, R. Sankowski, H. Dietrich, A. Oikonomidi, P. T. Huerta, J. Popp, Y. Al-Abed, M. Bacher
Journal Articles
No abstract provided.
Design And Application Of Single-Cell Rna Sequencing To Study Kidney Immune Cells In Lupus Nephritis, D. A. Rao, A. Arazi, D. Wofsy, B. Diamond
Design And Application Of Single-Cell Rna Sequencing To Study Kidney Immune Cells In Lupus Nephritis, D. A. Rao, A. Arazi, D. Wofsy, B. Diamond
Journal Articles
No abstract provided.
Unique White Matter Structural Connectivity In Early-Stage Drug-Naive Parkinson Disease, V. R. Mishra, K. R. Sreenivasan, Z. Yang, X. Zhuang, D. Cordes, Z. Mari, I. Litvan, H. H. Fernandez, D. Eidelberg, R. R. Walsh, +2 Additional Authors
Unique White Matter Structural Connectivity In Early-Stage Drug-Naive Parkinson Disease, V. R. Mishra, K. R. Sreenivasan, Z. Yang, X. Zhuang, D. Cordes, Z. Mari, I. Litvan, H. H. Fernandez, D. Eidelberg, R. R. Walsh, +2 Additional Authors
Journal Articles
© 2019 American Academy of Neurology. OBJECTIVE: To investigate the topographic arrangement and strength of whole-brain white matter (WM) structural connectivity in patients with early-stage drug-naive Parkinson disease (PD). METHODS: We employed a model-free data-driven approach for computing whole-brain WM topologic arrangement and connectivity strength between brain regions by utilizing diffusion MRI of 70 participants with early-stage drug-naive PD and 41 healthy controls. Subsequently, we generated a novel group-specific WM anatomical network by minimizing variance in anatomical connectivity of each group. Global WM connectivity strength and network measures were computed on this group-specific WM anatomical network and were compared between …
Creatinine Fluctuation In Patients With Lupus Nephritis: Considerations For Clinical Trial Endpoints, S. Almaani, U. Bhatt, C. Arriens, E. Bonfa, M. Dall'era, F. Houssiau, K. Kalunian, M. Mackay, J. Sanchez-Guerrero, B. H. Rovin, +1 Additional Author
Creatinine Fluctuation In Patients With Lupus Nephritis: Considerations For Clinical Trial Endpoints, S. Almaani, U. Bhatt, C. Arriens, E. Bonfa, M. Dall'era, F. Houssiau, K. Kalunian, M. Mackay, J. Sanchez-Guerrero, B. H. Rovin, +1 Additional Author
Journal Articles
No abstract provided.
Identification Of Unusual Phospholipids From Bovine Heart Mitochondria By Hplc-Ms/Ms., J. Kim, C. L. Hoppel
Identification Of Unusual Phospholipids From Bovine Heart Mitochondria By Hplc-Ms/Ms., J. Kim, C. L. Hoppel
Journal Articles
Phospholipids, including ether phospholipids, are composed of numerous isomeric and isobaric species that have the same backbone and acyl chains. This structural resemblance results in similar fragmentation patterns by collision-induced dissociation of phospholipids regardless of class, yielding complicated tandem mass spectrometry (MS/MS) spectra when isobaric species are analyzed together. Furthermore, the presence of isobaric species can lead to misassignment of species when made solely based on their molecular weights. In this study, we used normal-phase HPLC for ESI-MS/MS analysis of phospholipids from bovine heart mitochondria. Class separation by HPLC eliminates chances for misidentification of isobaric species from different classes of …
Radiomics And Supervised Machine Learning In The Diagnosis Of Parkinsonism With Fdg Pet: Promises And Challenges., S. Peng, P. G. Spetsieris, D. Eidelberg, Y. Ma
Radiomics And Supervised Machine Learning In The Diagnosis Of Parkinsonism With Fdg Pet: Promises And Challenges., S. Peng, P. G. Spetsieris, D. Eidelberg, Y. Ma
Journal Articles
No abstract provided.
Apol1 Polymorphism Modulates Sphingolipid Profile Of Human Podocytes, M. Valsecchi, V. Cazzetta, F. Oriolo, X. Lan, R. Piazza, M. A. Saleem, P. C. Singhal, D. Mavilio, J. Mikulak, M. Aureli
Apol1 Polymorphism Modulates Sphingolipid Profile Of Human Podocytes, M. Valsecchi, V. Cazzetta, F. Oriolo, X. Lan, R. Piazza, M. A. Saleem, P. C. Singhal, D. Mavilio, J. Mikulak, M. Aureli
Journal Articles
No abstract provided.
T Cell-Intrinsic Irf5 Regulates T Cell Signaling, Migration, And Differentiation And Promotes Intestinal Inflammation, J. Yan, S. P. Pandey, B. J. Barnes, J. R. Turner, C. Abraham
T Cell-Intrinsic Irf5 Regulates T Cell Signaling, Migration, And Differentiation And Promotes Intestinal Inflammation, J. Yan, S. P. Pandey, B. J. Barnes, J. R. Turner, C. Abraham
Journal Articles
© 2020 The Author(s) IRF5 polymorphisms are associated with multiple immune-mediated diseases, including ulcerative colitis. IRF5 contributions are attributed to its role in myeloid lineages. How T cell-intrinsic IRF5 contributes to inflammatory outcomes is not well understood. We identify a previously undefined key role for T cell-intrinsic IRF5. In mice, IRF5 in CD4+ T cells promotes Th1- and Th17-associated cytokines and decreases Th2-associated cytokines. IRF5 is required for the optimal assembly of the TCR-initiated signaling complex and downstream signaling at early times, and at later times binds to promoters of Th1- and Th17-associated transcription factors and cytokines. IRF5 also regulates …
Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report In Chronic Severe Spinal Cord Injury, O. Bloom, J. M. Wecht, B. E. Ditterline, S. Wang, A. Ovechkin, C. A. Angeli, A. A. Arcese, S. J. Harkema
Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report In Chronic Severe Spinal Cord Injury, O. Bloom, J. M. Wecht, B. E. Ditterline, S. Wang, A. Ovechkin, C. A. Angeli, A. A. Arcese, S. J. Harkema
Journal Articles
No abstract provided.
Plasma Metabolomics Supports The Use Of Long-Duration Cardiac Arrest Rodent Model To Study Human Disease By Demonstrating Similar Metabolic Alterations., M. Shoaib, R. C. Choudhary, J. Choi, N. Kim, K. Hayashida, T. Yagi, T. Yin, M. Nishikimi, L. B. Becker, J. Kim, +1 Additional Author
Plasma Metabolomics Supports The Use Of Long-Duration Cardiac Arrest Rodent Model To Study Human Disease By Demonstrating Similar Metabolic Alterations., M. Shoaib, R. C. Choudhary, J. Choi, N. Kim, K. Hayashida, T. Yagi, T. Yin, M. Nishikimi, L. B. Becker, J. Kim, +1 Additional Author
Journal Articles
Cardiac arrest (CA) is a leading cause of death and there is a necessity for animal models that accurately represent human injury severity. We evaluated a rat model of severe CA injury by comparing plasma metabolic alterations to human patients. Plasma was obtained from adult human control and CA patients post-resuscitation, and from male Sprague-Dawley rats at baseline and after 20 min CA followed by 30 min cardiopulmonary bypass resuscitation. An untargeted metabolomics evaluation using UPLC-QTOF-MS/MS was performed for plasma metabolome comparison. Here we show the metabolic commonality between humans and our severe injury rat model, highlighting significant metabolic dysfunction …
A Double-Blind, Placebo-Controlled, Phase Ii, Randomized Study Of Lovastatin Therapy In The Treatment Of Mildly Active Rheumatoid Arthritis, C. Aranow, J. Cush, M. B. Bolster, C. C. Striebich, M. Dall'era, M. Mackay, E. Olech, T. Frech, B. Diamond, A. Davidson Mbbs, +14 Additional Authors
A Double-Blind, Placebo-Controlled, Phase Ii, Randomized Study Of Lovastatin Therapy In The Treatment Of Mildly Active Rheumatoid Arthritis, C. Aranow, J. Cush, M. B. Bolster, C. C. Striebich, M. Dall'era, M. Mackay, E. Olech, T. Frech, B. Diamond, A. Davidson Mbbs, +14 Additional Authors
Journal Articles
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. 3-hydroxy-3-methylglutaryl coenzyme-A (HMG Co-A) reductase inhibitors (statins) are standard treatment for hyperlipidaemia. In addition to lipid-lowering abilities, statins exhibit multiple anti-inflammatory effects. The objectives of this study were to determine whether treatment of patients with RA with lovastatin decreased CRP or reduced disease activity. Methods: We conducted a randomized double-blind placebo-controlled 12 week trial of lovastatin vs placebo in 64 RA patients with mild clinical disease activity but an elevated CRP. The primary efficacy end point was the reduction …
Peripheral Nervous System Disease In Systemic Lupus Erythematosus: Results From An International Inception Cohort Study, J. G. Hanly, Q. Li, L. Su, M. B. Urowitz, C. Gordon, S. C. Bae, J. Romero-Diaz, C. Aranow, M. Mackay, V. Farewell, +33 Additional Authors
Peripheral Nervous System Disease In Systemic Lupus Erythematosus: Results From An International Inception Cohort Study, J. G. Hanly, Q. Li, L. Su, M. B. Urowitz, C. Gordon, S. C. Bae, J. Romero-Diaz, C. Aranow, M. Mackay, V. Farewell, +33 Additional Authors
Journal Articles
© 2019, American College of Rheumatology Objective: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. Results: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, …
Targeting Potential Drivers Of Covid-19: Neutrophil Extracellular Traps., Bj Barnes, Jm Adrover, A Baxter-Stoltzfus, A Borczuk, J Cools-Lartigue, Jm Crawford, J Daßler-Plenker, P Guerci, A Weber, M Egeblad, +13 Additional Authors
Targeting Potential Drivers Of Covid-19: Neutrophil Extracellular Traps., Bj Barnes, Jm Adrover, A Baxter-Stoltzfus, A Borczuk, J Cools-Lartigue, Jm Crawford, J Daßler-Plenker, P Guerci, A Weber, M Egeblad, +13 Additional Authors
Journal Articles
No abstract provided.
Iglv3-21∗01 Is An Inherited Risk Factor For Cll Through The Acquisition Of A Single-Point Mutation Enabling Autonomous Bcr Signaling, P. C. Maity, M. Bilal, M. T. Koning, M. Young, C. A. Van Bergen, V. Renna, A. Nicolò, A. N. Mazzarello, N. Chiorazzi, H. Jumaa, +28 Additional Authors
Iglv3-21∗01 Is An Inherited Risk Factor For Cll Through The Acquisition Of A Single-Point Mutation Enabling Autonomous Bcr Signaling, P. C. Maity, M. Bilal, M. T. Koning, M. Young, C. A. Van Bergen, V. Renna, A. Nicolò, A. N. Mazzarello, N. Chiorazzi, H. Jumaa, +28 Additional Authors
Journal Articles
© 2020 National Academy of Sciences. All rights reserved. The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations distinguishes mutated (M) CLL with a markedly superior prognosis from unmutated (UM) CLL cases. In addition, B cell antigen receptor (BCR) stereotypes as defined by IGHV usage and complementaritydetermining regions (CDRs) classify ∼30% of CLL cases into prognostically important subsets. Subset 2 expresses a BCR with the combination of IGHV3-21-derived heavy chains (HCs) with IGLV3- 21-derived light chains (LCs), …
Integrated Urine Proteomics And Renal Single-Cell Genomics Identify An Interferon-Γ Response Gradient In Lupus Nephritis., A. Fava, J. P. Buyon, C. Mohan, T. Zhang, H. M. Belmont, P. Izmirly, A. Arazi, A. Davidson, B. Diamond, M. Petri, +12 Additional Authors
Integrated Urine Proteomics And Renal Single-Cell Genomics Identify An Interferon-Γ Response Gradient In Lupus Nephritis., A. Fava, J. P. Buyon, C. Mohan, T. Zhang, H. M. Belmont, P. Izmirly, A. Arazi, A. Davidson, B. Diamond, M. Petri, +12 Additional Authors
Journal Articles
Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation. For example, proliferative nephritis identifies a more aggressive disease class that requires immunosuppression. However, the current classification system relies on the static appearance of histopathological morphology which does not capture differences in the inflammatory response. Therefore, a biomarker grounded in the disease biology is needed to understand the molecular heterogeneity of lupus nephritis and identify immunologic mechanism and pathways. Here, we analyzed the patterns of 1000 urine protein biomarkers in 30 patients with active lupus nephritis. We found that …
Eda2r Mediates Podocyte Injury In High Glucose Milieu, X. Lan, V. Kumar, A. Jha, R. Aslam, H. Wang, K. Chen, Y. Yu, W. He, A. Malhotra, P. C. Singhal, +2 Additional Authors
Eda2r Mediates Podocyte Injury In High Glucose Milieu, X. Lan, V. Kumar, A. Jha, R. Aslam, H. Wang, K. Chen, Y. Yu, W. He, A. Malhotra, P. C. Singhal, +2 Additional Authors
Journal Articles
© 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) EDA2R is a member of the large family of tumor necrosis factor receptor (TNFR). Previous studies suggested that EDA2R expression might be increased in the kidneys of diabetic mice. However, its mRNA and protein expression in kidneys were not analyzed; moreover, its role in the development of diabetic kidney disease was not explored. Here we analyzed the mRNA and protein expressions of EDA2R in diabetic kidneys and examined its role in the podocyte injury in high glucose milieu. By analysis with real-time PCR, Western blotting, we found …
Steroid Resistance In Diamond Blackfan Anemia Associates With P57(Kip2) Dysregulation In Erythroid Progenitors, R. J. Ashley, H. Yan, N. Wang, J. Hale, B. M. Dulmovits, J. Papoin, M. E. Olive, A. Vlachos, J. M. Lipton, L. Blanc, +8 Additional Authors
Steroid Resistance In Diamond Blackfan Anemia Associates With P57(Kip2) Dysregulation In Erythroid Progenitors, R. J. Ashley, H. Yan, N. Wang, J. Hale, B. M. Dulmovits, J. Papoin, M. E. Olive, A. Vlachos, J. M. Lipton, L. Blanc, +8 Additional Authors
Journal Articles
No abstract provided.
Correcting Smad1/5/8, Mtor, And Vegfr2 Treats Pathology In Hereditary Hemorrhagic Telangiectasia Models, S. Ruiz, H. Zhao, P. Chandakkar, J. Papoin, P. K. Chatterjee, Y. Al-Abed, P. Wang, C. N. Metz, L. Blanc, P. Marambaud, +8 Additional Authors
Correcting Smad1/5/8, Mtor, And Vegfr2 Treats Pathology In Hereditary Hemorrhagic Telangiectasia Models, S. Ruiz, H. Zhao, P. Chandakkar, J. Papoin, P. K. Chatterjee, Y. Al-Abed, P. Wang, C. N. Metz, L. Blanc, P. Marambaud, +8 Additional Authors
Journal Articles
No abstract provided.
Lupus Autoantibodies Act As Positive Allosteric Modulators At Glun2a-Containing Nmda Receptors And Impair Spatial Memory, K. Chan, J. Nestor, T. S. Huerta, N. Certain, G. Moody, C. Kowal, P. T. Huerta, B. T. Volpe, B. Diamond, L. P. Wollmuth
Lupus Autoantibodies Act As Positive Allosteric Modulators At Glun2a-Containing Nmda Receptors And Impair Spatial Memory, K. Chan, J. Nestor, T. S. Huerta, N. Certain, G. Moody, C. Kowal, P. T. Huerta, B. T. Volpe, B. Diamond, L. P. Wollmuth
Journal Articles
No abstract provided.
Irf5 Genetic Risk Variants Drive Myeloid-Specific Irf5 Hyperactivation And Presymptomatic Sle, D. Li, B. Matta, S. Song, V. Nelson, K. Diggins, K. R. Simpfendorfer, P. K. Gregersen, P. Linsley, B. J. Barnes
Irf5 Genetic Risk Variants Drive Myeloid-Specific Irf5 Hyperactivation And Presymptomatic Sle, D. Li, B. Matta, S. Song, V. Nelson, K. Diggins, K. R. Simpfendorfer, P. K. Gregersen, P. Linsley, B. J. Barnes
Journal Articles
No abstract provided.
Pharmacological Prevention Of Surgery-Accelerated Metastasis In An Animal Model Of Osteosarcoma, M. P. Kallis, C. Maloney, B. Blank, S. Z. Soffer, M. Symons, B. M. Steinberg
Pharmacological Prevention Of Surgery-Accelerated Metastasis In An Animal Model Of Osteosarcoma, M. P. Kallis, C. Maloney, B. Blank, S. Z. Soffer, M. Symons, B. M. Steinberg
Journal Articles
No abstract provided.
Aid Overlapping And Polη Hotspots Are Key Features Of Evolutionary Variation Within The Human Antibody Heavy Chain (Ighv) Genes, C. Tang, D. Bagnara, N. Chiorazzi, M. D. Scharff, T. Maccarthy
Aid Overlapping And Polη Hotspots Are Key Features Of Evolutionary Variation Within The Human Antibody Heavy Chain (Ighv) Genes, C. Tang, D. Bagnara, N. Chiorazzi, M. D. Scharff, T. Maccarthy
Journal Articles
© Copyright © 2020 Tang, Bagnara, Chiorazzi, Scharff and MacCarthy. Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context of WRC/GYW (W = A/T, R = A/G, Y = C/T) and particularly at WGCW overlapping hotspots where hotspots appear opposite each other on both strands. Subsequent recruitment of the low-fidelity DNA repair enzyme, Polymerase eta (Polη), during mismatch repair, creates additional mutations at WA/TW sites. Although …
Advanced Neuroimaging In Neuropsychiatric Systemic Lupus Erythematosus, M. Mackay, C. C. Tang, A. Vo
Advanced Neuroimaging In Neuropsychiatric Systemic Lupus Erythematosus, M. Mackay, C. C. Tang, A. Vo
Journal Articles
PURPOSE OF REVIEW: Neuropsychiatric lupus (NPSLE) comprises a disparate collection of syndromes affecting the central and peripheral nervous systems. Progress in the attribution of neuropsychiatric syndromes to SLE-related mechanisms and development of targeted treatment strategies has been impeded by a lack of objective imaging biomarkers that reflect specific neuropsychiatric syndromes and/or pathologic mechanisms. The present review addresses recent publications of neuroimaging techniques in NPSLE. RECENT FINDINGS: Imaging studies grouping all NPSLE syndromes together are unable to differentiate between NPSLE and non-NPSLE. In contrast, diffusion tensor imaging, FDG-PET, resting, and functional MRI techniques in patients with stable non-NPSLE demonstrate abnormal network …
Inhibition Of Irf5 Cellular Activity With Cell-Penetrating Peptides That Target Homodimerization, J. Banga, D. Srinivasan, C. Sun, C. D. Thompson, F. Milletti, K. Huang, S. Song, B. Matta, D. Li, B. J. Barnes, +17 Additional Authors
Inhibition Of Irf5 Cellular Activity With Cell-Penetrating Peptides That Target Homodimerization, J. Banga, D. Srinivasan, C. Sun, C. D. Thompson, F. Milletti, K. Huang, S. Song, B. Matta, D. Li, B. J. Barnes, +17 Additional Authors
Journal Articles
No abstract provided.
Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos
Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos
Journal Articles
© 2020, The Author(s). Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for …