Medical Sciences Commons^™

Characterizing The Roles Of Cannabinoid Receptor 1 & 2 In Zebrafish Behavior, Metabolism, And Seizure-Induced Activity, Kayci Kimmons

Honors Theses

Epileptic disorders like Dravet Syndrome require novel studies to determine the most ideal treatment. New research linking the endocannabinoid system (ECS) to epileptic disorders is arising, but there is still much to be discovered about the function and regulatory impact of the endocannabinoid system and its receptors in epilepsies like Dravet. In this study, knockout models of larval and adult zebrafish (Danio rerio) were used to investigate the roles of cannabinoid receptors 1 & 2 in behavior, brain mitochondrial metabolism, and seizure-induced activity following exposure to THC and CBD. Larval zebrafish which lacked cannabinoid receptor 1 exhibited increased …

Calcium Metabolism Of Bone In Microgravity: An Investigation And Simulation Of Bone Demineralization In Space, Benjamin Peacock

Honors Theses

Extended space exploration poses many physiological problems that must be overcome before humanity can reach past the boundaries of Earth's orbit. The farthest a human has been able to travel is to the moon and back, and currently astronauts are confined to orbiting the Earth. While many astronauts and cosmonauts have remained aboard the space station Mir for months, their stay was not without detrimental effects upon their return. Currently, the International Space Station and missions to Mars are the projects involving humans in space at the National Aeronautics and Space Administration (NASA).

In this experiment, a ground-based simulation utilizing …