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Metabolic Therapy For Temporal Lobe Epilepsy In A Dish: Investigating Mechanisms Of Ketogenic Diet Using Electrophysiological Recordings In Hippocampal Slices, Masahito Kawamura Jr., David N. Ruskin, Susan A. Masino

Faculty Scholarship

The hippocampus is prone to epileptic seizures and is a key brain region and experimental platform for investigating mechanisms associated with the abnormal neuronal excitability that characterizes a seizure. Accordingly, the hippocampal slice is a common in vitro model to study treatments that may prevent or reduce seizure activity. The ketogenic diet is a metabolic therapy used to treat epilepsy in adults and children for nearly 100 years; it can reduce or eliminate even severe or refractory seizures. New insights into its underlying mechanisms have been revealed by diverse types of electrophysiological recordings in hippocampal slices. Here we review these …