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Role Of Igf-Ii, Prl, And Fabps In The Breast Cancer Disparity Among Aa Women, Teleka Cassandra Patrick
Role Of Igf-Ii, Prl, And Fabps In The Breast Cancer Disparity Among Aa Women, Teleka Cassandra Patrick
Loma Linda University Electronic Theses, Dissertations & Projects
It is well documented that African-American (AA) patients present with more advanced states of breast cancer and have lower survival rates than Caucasian-Americans (CA). Epidemiological data have shown that pregnancy and lactation at an early age in humans reduce the risk of breast cancer. Studies in mice and rats have shown that lactation stimulates the expression of intracellular fatty-acid binding protein 3 (FABP3). FABP3 is detected in human breast tissue and is known as mammary-derived growth inhibitor (MDGI) because it has a strong inhibitory effect on cell proliferation. FABP5 is also expressed in the breast, and has been associated with …