Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medical Sciences
Mechanisms Of Persistent Translation Arrest Following Global Brain Ischemia And Reperfusion, Jill Theresa Jamison
Mechanisms Of Persistent Translation Arrest Following Global Brain Ischemia And Reperfusion, Jill Theresa Jamison
Wayne State University Dissertations
ABSTRACT
MECHANISMS OF PERSISTENT TRANSLATION ARREST FOLLOWING GLOBAL BRAIN ISCHEMIA and REPERFUSION
by
JILL T. JAMISON
December 2011
Advisor: Donald J. DeGracia, Ph.D.
Major: Physiology
Degree: Doctor of Philosophy
The information presented here studies the mechanisms that underlie persistent translation arrest (TA) following global brain ischemia and reperfusion (I/R). To summarize the main findings I have discovered a new mechanism for prolonged post-ischemic TA that correlated exactly with in vivo translation rates and correlated precisely with cell outcome. Through the extensive colocalization studies, my results indicate that the mRNA granules are ribonomic structures involved with mRNA regulation. This finding is …
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Wayne State University Dissertations
MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN
ISCHEMIA
by
MONIQUE K. LEWIS
August 2011
Advisor: Dr. Donald DeGracia
Major: Physiology
Degree: Doctor of Philosophy
The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …