Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Medical Sciences
Non-St Elevation Myocardial Infarction Presentation In Severe Aortic Stenotic Patient, Margi Desai, Daniel Maysonet
Non-St Elevation Myocardial Infarction Presentation In Severe Aortic Stenotic Patient, Margi Desai, Daniel Maysonet
The Journal of Integrated Primary Care
This case report demonstrates a patient who presents with typical findings for a diagnosis of NSTEMI. Upon further evaluation, this diagnosis was able to be ruled out. Presentations and labs consistent with NSTEMI masked the true diagnosis of aortic stenosis due to oxygen supply/demand mismatch.
Seniors Welcome! Avoiding The Trap Of Age Limits In Health Research, Arshad Jahangir
Seniors Welcome! Avoiding The Trap Of Age Limits In Health Research, Arshad Jahangir
Journal of Patient-Centered Research and Reviews
The guest editor introduces this specialty issue of the Journal of Patient-Centered Research and Reviews, which focuses on cardiovascular diseases in the elderly. The reality of an aging population has increased the need for better evidence-based medicine in older patients. However, randomized controlled trials frequently exclude such patients, especially those with comorbidities, from study. This practice ignores the fact that physiologic changes to the cardiovascular system caused by the aging process and aging-associated diseases create clinical dilemmas distinct from those in younger patients. Considering the rising costs of health care and growing incidence of cardiovascular disease, research efforts and …
Atrial Fibrillation Promotion By Intermittent Hypoxia In The Rat, Sara Bober
Atrial Fibrillation Promotion By Intermittent Hypoxia In The Rat, Sara Bober
Electronic Thesis and Dissertation Repository
Obstructive sleep apnea (OSA) is a significant risk factor for developing atrial fibrillation (AF) in clinical populations, but the underlying mechanisms are unknown. Intermittent hypoxia (IH), as elicited by nocturnal airway obstructive events in OSA patients, has been implicated as the mediator of OSA-related cardiovascular outcomes. However, the role of IH in OSA-related atrial arrhythmogenesis has not been reported. For the first time, this thesis demonstrates AF promotion in a rodent model of OSA using IH to mimic hypoxic events, and investigates the underlying vulnerable substrates of induced AF. Rats exposed to IH for 7 days had significantly enhanced AF …
Mechanisms Of Atrial Arrhythmia: Investigations Of The Neuro-Myogenic Interface In The Mouse, Jari Michael Tuomi
Mechanisms Of Atrial Arrhythmia: Investigations Of The Neuro-Myogenic Interface In The Mouse, Jari Michael Tuomi
Electronic Thesis and Dissertation Repository
Arrhythmia mechanisms rely on multiple factors including structural (myogenic), nervous (neurogenic), and interrelated (the neuro-myogenic interface) factors. I hypothesized that due to this neuro-myogenic interface, the intrinsic cardiac autonomic nervous system (ICANS) is involved in most atrial arrhythmias. This thesis also provides a "Threshold Model" as a tool to assess the role of different physiological factors influencing arrhythmia. This model allows relative comparison and interpretation of the role of various factors influencing arrhythmogenesis. The mouse allows relatively simple manipulation of genes to determine their role in arrhythmia. This thesis determined what atrial arrhythmias are inducible in the mouse (in vivo) …