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- Androgen receptor (1)
- Astrocytes (1)
- Astrogliosis (1)
- Cognitive control (1)
- Cortical reorganization (1)
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- Diffusion tensor imaging (1)
- Dorsolateral prefrontal cortex (1)
- Dynamic causal modeling (1)
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Articles 1 - 3 of 3
Full-Text Articles in Medical Sciences
Brain Activation And Connectivity In Non-Disabled Multiple Sclerosis Patients, Rene A. Colorado
Brain Activation And Connectivity In Non-Disabled Multiple Sclerosis Patients, Rene A. Colorado
Dissertations & Theses (Open Access)
Multiple sclerosis (MS) is the most common demyelinating disease affecting the central nervous system. There is no cure for MS and current therapies have limited efficacy. While the majority of individuals with MS develop significant clinical disability, a subset experiences a disease course with minimal impairment even in the presence of significant apparent tissue damage on magnetic resonance imaging (MRI). The current studies combined functional MRI and diffusion tensor imaging (DTI) to elucidate brain mechanisms associated with lack of clinical disability in patients with MS. Recent evidence has implicated cortical reorganization as a mechanism to limit the clinical manifestation of …
The Role Of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation, Bryce H. Vincent
The Role Of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation, Bryce H. Vincent
Dissertations & Theses (Open Access)
Astrogliosis is induced by neuronal damage and is also a pathological feature of the major aging-related neurodegenerative disorders. The mechanisms that control the cascade of astrogliosis have not been well established. In a previous study, we identified a novel androgen receptor (AR)-interacting protein (p44/WDR77) and found that it plays a critical role in the control of proliferation and differentiation of prostate epithelial cells. In the present study, we found that deletion of the p44 gene in the mouse brain caused accelerated aging with dramatic astrogliosis. The p44/WDR77 is expressed in astrocytes and loss of p44/WDR77 expression in astrocytes leads to …
Prevalence Of Premature Ovarian Failure In Women With Tuberous Sclerosis, Emily Gabitzsch
Prevalence Of Premature Ovarian Failure In Women With Tuberous Sclerosis, Emily Gabitzsch
Dissertations & Theses (Open Access)
Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor suppressor disorder characterized by hamartomas, or benign growths, in various organ systems. Inactivating mutations in either the TSC1 or the TSC2 gene cause most cases of TSC. Recently, the use of ovarian specific conditional knock-out mouse models has demonstrated a crucial role of the TSC genes in ovarian function. Mice with complete deletion of Tsc1 or Tsc2 showed accelerated ovarian follicle activation and subsequent premature follicular depletion, consistent with the human condition premature ovarian failure (POF). POF is defined in women as the cessation of menses before the age of 40 …