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Multiple System Atrophy: Case Of Atypicalparkinson With Parkinson Predominant Presentation And Progressive Cerebellar Degeneration With Extrapyramidal And Autonomic Involvement, Aayushi Sharma
Digital Journal of Clinical Medicine
ABSTRACT
BACKGROUND
Multiple System Atrophy is a rapidly progressive neurodegenerative disease. Symptoms tend to appear in 50s and advance rapidly over the course of 5-10 years with progressive loss of motor and autonomic function.
Some of the common symptoms include frequent falls with or without tremors and b/l akinetic rigidity with involvement of the axial muscles. Postural tremor, severe stridor and cranio cervical dystonia may be seen. Alpha synnuclenopathies are generally characterized by REM behavioral disorders and severe dysautonomia years before the onset of the disease.
Individuals with MSA typically do not have sustained improvement in their symptoms with levodopa. …