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Full-Text Articles in Medical Sciences
Transcriptional Activity Of Core Binding Factor-Alpha (Aml1) And Beta Subunits On Murine Leukemia Virus Enhancer Cores., Ari L. Zaiman, Amy F. Lewis, Barbara E. Crute, N. A. Speck, Jack Lenz
Transcriptional Activity Of Core Binding Factor-Alpha (Aml1) And Beta Subunits On Murine Leukemia Virus Enhancer Cores., Ari L. Zaiman, Amy F. Lewis, Barbara E. Crute, N. A. Speck, Jack Lenz
Dartmouth Scholarship
Core binding factor (CBF), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus family of retroviruses. The core elements of the SL3 virus are important genetic determinants of the ability of this virus to induce T-cell lymphomas and the transcriptional activity of the viral long terminal repeat in T lymphocytes. CBF consists of two subunits, a DNA binding subunit, CBF alpha, and a second subunit, CBF beta, that stimulates the DNA binding activity of CBF alpha. …
The Leukemic Core Binding Factor Beta-Smooth Muscle Myosin Heavy Chain (Cbf Beta-Smmhc) Chimeric Protein Requires Both Cbf Beta And Myosin Heavy Chain Domains For Transformation Of Nih 3t3 Cells., Amitav Hajra, Pu Liu, Qing Wang, Christine Kelley
The Leukemic Core Binding Factor Beta-Smooth Muscle Myosin Heavy Chain (Cbf Beta-Smmhc) Chimeric Protein Requires Both Cbf Beta And Myosin Heavy Chain Domains For Transformation Of Nih 3t3 Cells., Amitav Hajra, Pu Liu, Qing Wang, Christine Kelley
Dartmouth Scholarship
An inversion of chromosome 16 associated with the M4Eo subtype of acute myeloid leukemia produces a chimeric protein fusing the beta subunit of the transcription factor core binding factor (CBF beta) to the tail region of smooth muscle myosin heavy chain (SMMHC). We investigated the oncogenic properties of this CBF beta-SMMHC chimeric protein using a 3T3 transformation assay. NIH 3T3 cells expressing CBF beta-SMMHC acquired a transformed phenotype, as indicated by their ability to form foci, grow in soft agarose, and form tumors in nude mice. Cells expressing normal CBF beta or the SMMHC tail domain did not become transformed. …