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Full-Text Articles in Medical Sciences
Effect Of Testosterone On Inflammatory Markers In The Development Of Early Atherogenesis In The Testicular-Feminized Mouse Model, Daniel Kelly, Donna Sellers, M. Woodroofe, T. Jones, Kevin Channer
Effect Of Testosterone On Inflammatory Markers In The Development Of Early Atherogenesis In The Testicular-Feminized Mouse Model, Daniel Kelly, Donna Sellers, M. Woodroofe, T. Jones, Kevin Channer
Donna Sellers
Background: Low levels of serum testosterone in men are associated with cardiovascular disease. Clinical studies show that testosterone replacement therapy (TRT) can improve symptoms of cardiovascular disease and reduce the inflammatory burden evident in atherosclerosis.
Aim: We used an in vivo animal model to determine whether testosterone influences mediators of vascular inflammation as part of its beneficial effects on atherogenesis.
Methods: Testicular-feminized (Tfm) mice, which express low endogenous testosterone and a non-functional androgen receptor (AR), were used to assess the effect of androgen status on atheroma formation, serum lipids, and inflammatory mediators. Tfm mice were fed a high-cholesterol diet, received …
Diabetes Induced Changes In Rat Mesenchymal Stem Cells, Alexandra Stolzing, Donna Sellers, Owen Llewelyn, Andy Scutt
Diabetes Induced Changes In Rat Mesenchymal Stem Cells, Alexandra Stolzing, Donna Sellers, Owen Llewelyn, Andy Scutt
Donna Sellers
Diabetes mellitus, the single most important cause of vascular disease in the industrialized world, is also associated with bone loss and impaired fracture healing. Mesenchymal stem cells (MSCs) have the potential to differentiate into osteoblasts, chondrocytes and adipocytes and other mesenchymal cells and play a central role in bone formation and repair. Because of this, we have investigated the possibility that diabetes has direct effects on MSCs in vivo and that this might represent a cellular basis for diabetes-induced osteoporosis. We isolated MSCs from rats with streptozotocin-induced diabetes and analysed them ex vivo for their ability to proliferate and differentiate …