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Tspo Pet Detects Acute Neuroinflammation But Not Diffuse Chronically Activated Mhcii Microglia In The Rat, Nassir Al-Khishman
Tspo Pet Detects Acute Neuroinflammation But Not Diffuse Chronically Activated Mhcii Microglia In The Rat, Nassir Al-Khishman
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Abstract
Background
Accurate and sensitive imaging biomarkers are required to study the progression of white matter (WM) microglial activation in neurological diseases in vivo. The translocator protein (TSPO) is considered a sensitive target for imaging microglial activation with positron emission tomography (PET). This study aimed to test the ability of TSPO to detect WM microglial activation marked by major histocompatibility complex class II (MHCII) molecules in rat models of prodromal Alzheimer’s disease and acute subcortical stroke.
Methods
Fischer 344 wild-type (n = 12) and TgAPP21 (n = 11) rats were imaged with [18F]FEPPA PET and MRI to …