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Characterization Of Palmitic Acid Induced Lipotoxicity In Schwann Cells, Amelia Padilla
Characterization Of Palmitic Acid Induced Lipotoxicity In Schwann Cells, Amelia Padilla
Loma Linda University Electronic Theses, Dissertations & Projects
Lipotoxicity is a response to lipid overload that has been associated with cellular dysfunction leading to cellular death. The mechanism of lipotoxicity and its impact on the nervous system is critical as it can lead to debilitating neurological conditions. This study examines key cellular events induced by palmitic acid lipotoxicity (PA-LTx) in Schwann cells cultured in euglycemic and hyperglycemic conditions. The data show that immortalized Schwann cell (iSC), as well as primary Schwann cell (pSC) cultures exposed to elevated levels of PA induced an apoptotic cell death that is dose and time-dependent. The earliest indication of cellular dysfunction was a …