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Muscle Plasticity And Intramuscular Signaling In The Insulin-Resistant Obese Zucker Rat, Anjaiah Katta
Muscle Plasticity And Intramuscular Signaling In The Insulin-Resistant Obese Zucker Rat, Anjaiah Katta
Theses, Dissertations and Capstones
The ability to increase skeletal muscle mass may have important implications for the treatment of insulin resistance (IR) and diabetes [1-3]. Recent data suggest that IR muscle may adapt differently than normal muscle; however, molecular mechanism(s) responsible for this finding are not well understood [4]. Herein, we investigate the molecular mechanisms underlying the skeletal muscle remodeling in the IR Obese Zucker (OZ) rat.
The OZ rat is characterized by skeletal muscle insulin resistance, hyperglycemia, and hyperlipidemia. Compared to LZ rats, our data demonstrate that soleus muscle hypertrophy was significantly attenuated in the OZ rats after 3-weeks of muscle overload and …