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- Keyword
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- Acute respiratory distress syndrome (1)
- Cholesterol (1)
- Diet (1)
- Hypercholesterolemia (1)
- Mitochondria (1)
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- Mitochondrial membrane (1)
- Neuron (1)
- O2 uptake kinetics; near-infrared spectroscopy; NIRS; metabolism; intramuscular metabolites (1)
- Respiratory chain (1)
- Stem cell factor; Myocardial infarction; Cardiac remodeling ; Endothelial progenitor cells; Angiogenesis; Epicardium-derived cells ; Cardiac stem cells (1)
- Stomatin-like protein 2 (1)
- Surfactant (1)
- Surfactant protein-A (1)
Articles 1 - 4 of 4
Full-Text Articles in Medical Sciences
Cholesterol-Mediated Dysfunction Of Surfactant Effects Of Surfactant Protein-A And Diet-Induced Hypercholesterolemia, Joshua Qua Hiansen
Cholesterol-Mediated Dysfunction Of Surfactant Effects Of Surfactant Protein-A And Diet-Induced Hypercholesterolemia, Joshua Qua Hiansen
Electronic Thesis and Dissertation Repository
This thesis explored the effects of cholesterol and SP-A on surfactant function in vitro, and lung function in vivo. In the first experiment, we determined whether SP-A could mitigate cholesterol-mediated surfactant dysfunction. We hypothesized that SP-A can mitigate the surfactant inhibition caused by high cholesterol. In the second experiment, we tested the contribution of diet-induced serum hypercholesterolemia to surfactant composition and the development of lung injury in rats. We hypothesized that serum hypercholesterolemia would increase the amount of cholesterol in surfactant and would cause rats to develop more severe lung injury. Our results indicate that SP-A mitigates cholesterol-mediated surfactant …
Adjustment Of Pulmonary O2 Uptake, Muscle Deoxygenation And Metabolism During Moderate-Intensity Exercise Transitions Initiated From Low And Elevated Baseline Metabolic Rates, Joshua P. Nederveen
Adjustment Of Pulmonary O2 Uptake, Muscle Deoxygenation And Metabolism During Moderate-Intensity Exercise Transitions Initiated From Low And Elevated Baseline Metabolic Rates, Joshua P. Nederveen
Electronic Thesis and Dissertation Repository
When instantaneous step-wise transitions within the moderate intensity domain are initiated from elevated metabolic rates, the rate of pulmonary oxygen uptake (V̇O2p) adjustment is slowed, and the V̇O2p gain (ΔV̇O2p /ΔWR) is greater. This study sought to determine the relationship between V̇O2p kinetics and metabolic activity and energy status during step transitions from low and elevated metabolic rates within the moderate intensity domain. Ten young men completed six double-step constant load cycling bouts, consisting of step-wise transitions from 20 W to 45% θL and 45% θL [lower step (LS)] to 90% θL …
Characterizing Stomatin-Like Protein 2 And Its Role In Neuron Survival, Lisa A. Foris
Characterizing Stomatin-Like Protein 2 And Its Role In Neuron Survival, Lisa A. Foris
Electronic Thesis and Dissertation Repository
Stomatin-like Protein 2 (SLP-2) has been identified as a stress-inducible transcript and has been shown to interact with and stabilize mitochondrial proteins. Since mitochondria are critical for neuronal function, we hypothesized that SLP-2 regulates neuron survival in response to stressful stimuli. A conditional SLP-2 knockout mouse (deletion) and the SN56 cell line (upregulation) were employed to study the role of SLP-2 in mitochondrial dynamics and neuron survival. SLP-2 deficient primary cortical neurons displayed significantly decreased levels of various mitochondrial respiratory chain proteins, indicating SLP-2 contributes to maintenance of mitochondrial membrane integrity. SLP-2 was up-regulated in response to oxidative stress and …
Improving Cardiac Repair By Stem Cell Factor Post-Myocardial Infarction, Fuli Xiang
Improving Cardiac Repair By Stem Cell Factor Post-Myocardial Infarction, Fuli Xiang
Electronic Thesis and Dissertation Repository
Myocardial infarction (MI) occurs due to the complete occlusion of a coronary artery and is a leading cause of death, and a huge social and economic burden worldwide. Despite advances in treatment, patients still have a poor prognosis and there is a pressing need for strategies to improve cardiac repair post-MI. Stem cell factor (SCF), expressed by many cells and tissues including the myocardium, binds to its receptor, c-kit, and regulates the activity of c-kit-expressing cells. SCF has two isoforms: a soluble (S-SCF), and a membrane-associated isoform (M-SCF). M-SCF is more potent in supporting cell adhesion and survival. …