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Full-Text Articles in Medical Sciences
Acute Ethanol Modulates Synaptic Inhibition In The Basolateral Amygdala Via Rapid Nlrp3 Inflammasome Activation And Regulates Anxiety-Like Behavior In Rats, Soumyabrata Munshi, Lucas Albrechet-Souza, Raoni Conceição Dos-Santos, Claire E. Stelly, Maria E. Secci, Nicholas W. Gilpin, Jeffrey G. Tasker
Acute Ethanol Modulates Synaptic Inhibition In The Basolateral Amygdala Via Rapid Nlrp3 Inflammasome Activation And Regulates Anxiety-Like Behavior In Rats, Soumyabrata Munshi, Lucas Albrechet-Souza, Raoni Conceição Dos-Santos, Claire E. Stelly, Maria E. Secci, Nicholas W. Gilpin, Jeffrey G. Tasker
School of Graduate Studies Faculty Publications
Chronic alcohol exposure leads to a neuroinflammatory response involving activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome and pro-inflammatory cytokine production. Acute ethanol (EtOH) exposure activates GABAergic synapses in the central and basolateral amygdala (BLA) ex vivo, but whether this rapid modulation of synaptic inhibition is due to an acute inflammatory response and alters anxiety-like behavior in male and female animals is not known. Here, we tested the hypotheses that acute EtOH facilitates inhibitory synaptic transmission in the BLA by activating the NLRP3 inflammasome-dependent acute inflammatory response, that the alcohol-induced increase in inhibition is cell type- and …