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Comparative Analysis Of Autologous Chondrocyte Implantation And Other Treatment Modalities: A Systematic Review, Sangeetha Naveen, Noorzurani Robson Associate Prof. Dr., Tunku Kamarul
Comparative Analysis Of Autologous Chondrocyte Implantation And Other Treatment Modalities: A Systematic Review, Sangeetha Naveen, Noorzurani Robson Associate Prof. Dr., Tunku Kamarul
Associate Prof. Dr. Noorzurani Robson
Abstract Purpose: The purpose of this systematic review was to analyze and determine the effectiveness of Autologous Chondrocyte Implantation (ACI) when compared with other treatment modalities which includes microfracture, mosaicplasty, abrasionplasty, bone marrow derived mesenchymal stem cell (BMSC) and matrix assisted autologous chondrocyte implantation (MACI). Methods: Literature search using online databases PubMed, Scopus, National Institute for Clinical Excellence (NICE) and Cochrane Controlled Trial Register regarding all cell based therapies and other interventions for chondral lesions was explored. Data on clinical outcome and repair quality were analyzed. Duplicates and irrelevant articles were omitted. Result: Seventeen (n=17) studies were included in this …
Prevalence And Molecular Study Of G6pd Deficiency In Malaysian Orang Asli, Farahnaz Amini
Prevalence And Molecular Study Of G6pd Deficiency In Malaysian Orang Asli, Farahnaz Amini
Farahnaz Amini
This study aims to define the prevalence and the molecular basis of G6PD deficiency in the Negrito tribe of the Malaysian Orang Asli. Four hundred and eighty seven consenting Negrito volunteers were screened for G6PD deficiency through the use of a fluorescent spot test. DNA from deficient individuals underwent PCR-RFLP analysis using thirteen recognized G6PD mutations. In the instances when the mutation could not be identified by PCR-RFLP, the entire coding region of the G6PD gene was subjected to DNA sequencing. In total, 9% (44/486) of the sample were found to be G6PD-deficient. However, only 25 samples were subjected to …