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Prevalence And Molecular Study Of G6pd Deficiency In Malaysian Orang Asli, Farahnaz Amini
Prevalence And Molecular Study Of G6pd Deficiency In Malaysian Orang Asli, Farahnaz Amini
Farahnaz Amini
This study aims to define the prevalence and the molecular basis of G6PD deficiency in the Negrito tribe of the Malaysian Orang Asli. Four hundred and eighty seven consenting Negrito volunteers were screened for G6PD deficiency through the use of a fluorescent spot test. DNA from deficient individuals underwent PCR-RFLP analysis using thirteen recognized G6PD mutations. In the instances when the mutation could not be identified by PCR-RFLP, the entire coding region of the G6PD gene was subjected to DNA sequencing. In total, 9% (44/486) of the sample were found to be G6PD-deficient. However, only 25 samples were subjected to …