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Diseases Commons

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Full-Text Articles in Diseases

Development Of Catalytic Rnas As Potential Anti-Hiv-1 Agents, Pairoj Sae Chang Aug 1990

Development Of Catalytic Rnas As Potential Anti-Hiv-1 Agents, Pairoj Sae Chang

Loma Linda University Electronic Theses, Dissertations & Projects

RNA molecules with enzymatic activity (ribozymes) targeted to the genome of HIV-1 were developed and demonstrated to mediate site-specific cleavage of the HIV-1 RNA in vitro and to inhibit viral proliferation intracellularly. Two classes of ribozymes that incorporate a "hammerhead" catalytic center were utilized, eotide elements in the viral sequence to provide half of the The first class used nuclcatalytic center. A complementary strand harboring the remaining active site nucleotides was supplied in trans and directed the site-specific cleavage of the HIV-1 RNA target. A second type of ribozyme incorporated the entire catalytic center, minus the site of cleavage, within …


An Explanatory Study Of Maternal Stress And Coping With A Cystic Fibrosis Child, Leslie G. Potter May 1990

An Explanatory Study Of Maternal Stress And Coping With A Cystic Fibrosis Child, Leslie G. Potter

Nursing Theses & Dissertations

The purpose of this study was to explore the concept of coping with a cystic fibrosis (CF) child and to define coping strategies from the perspective of the mother. The research design was based upon a phenomenological approach with analysis of transcribed, semi-structured interviews with mothers of CF children. A purposive sample of eight mothers with CF children were interviewed to explore the maternal CF experience. Each interview was tape recorded and followed up with a phone call to allow the mothers to add additional information, if so desired. Data analysis consisted of reviewing each typed, verbatim transcript to categorize …


Characterization Of Minchinia Sp Spores (Ascetospora: Haplosporidiidae) Infecting Teredo Navalis L And Placopecten Magellanicus Von Martens (Mollusca: Teredinidae) In The Western North Atlantic, Elizabeth Robinson Mcgovern Jan 1990

Characterization Of Minchinia Sp Spores (Ascetospora: Haplosporidiidae) Infecting Teredo Navalis L And Placopecten Magellanicus Von Martens (Mollusca: Teredinidae) In The Western North Atlantic, Elizabeth Robinson Mcgovern

Dissertations, Theses, and Masters Projects

No abstract provided.