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Full-Text Articles in Diseases
Correlation Of Amyloid Beta And Spatial Learning And Memory Deficits On A Thy1-App Mouse Model For Alzheimer's Disease, Amber Lynn Betz
Correlation Of Amyloid Beta And Spatial Learning And Memory Deficits On A Thy1-App Mouse Model For Alzheimer's Disease, Amber Lynn Betz
Theses and Dissertations - UTB/UTPA
The McGill-Thy1 APP mouse is a triple transgenic model of Alzheimer disease, which has the mutant amyloid precursor protein to synergistically over-produce amyloid beta plaques. These mice exhibit visuo-spatial learning impairment at 3 months of age and memory impairment at 10-13 months of age in the Morris water maze. To extend these findings mice at 3, 5, and 7 months of age were tested on the Barnes maze. Non-Transgenic and Transgenic mice showed improvement during acquisition. However, 3 month and 5 month McGill Thy1- APP mice showed impaired acquisition learning while 7 month showed a learning and memory deficit compared …
Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon
Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon
Theses and Dissertations - UTB/UTPA
Theta oscillation is the largest extracellular synchronous signal that can be recorded from the mammalian brain. It is known to influence information retention in the hippocampus, which plays a key role in declarative memory, recognition memory, working memory, and spatial memory. The theta oscillation field frequency is between 3 and 12 Hz and is present during exploratory behavior and sleep in rodents. Theta rhythm in the hippocampus is postulated to be produced by the rhythmical activity of pacemaking cells in the medial septumvertical limb of the diagonal band of Broca (MS-vDBB). Previous work in our laboratory demonstrated the existence of …