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Articles 1 - 11 of 11
Full-Text Articles in Diseases
Investigating The Role Of Integrin Beta 3 In Dendritic Arborization In The Supragranular Developing Cerebral Cortex, Zachary Logan Holley
Investigating The Role Of Integrin Beta 3 In Dendritic Arborization In The Supragranular Developing Cerebral Cortex, Zachary Logan Holley
Senior Honors Projects, 2010-2019
Integrin subunits have been implicated in axonal and dendritic outgrowth. In particular, a strong positive association has been found between mutations in integrin beta 3 (Itgb3) and autism spectrum disorder, but little is known about neuronal Itgb3 function in vivo. Many forms of autism spectrum disorder are thought to arise from dysfunctional dendritic arborization and synaptic pruning. Global knockout of Itgb3 in mice leads to autistic-like behaviors. Itgb3-/- mice also have reduced callosal volume, a key neuroanatomical correlate of autism. Here, we test the hypothesis that Itgb3 is required for normal dendritic arborization in layer II/III pyramidal …
Characterization Of Isolates And Whole Samples From Turkeys Infected With Bordetellosis, Alexandra Lovrinic
Characterization Of Isolates And Whole Samples From Turkeys Infected With Bordetellosis, Alexandra Lovrinic
Senior Honors Projects, 2010-2019
Bordetellosis is a disease in turkeys attributed to the Gram-negative bacterium, Bordetella avium. The closely related species, B. hinzii, is known to colonize in turkeys as well but was not thought to cause disease. However, over the past few years, B. hinzii has been isolated from turkeys diagnosed with bordetellosis. The presumed identification of isolates obtained from Butterball farms in different locations was conducted through standard identification tests, including hemagglutination, PCR of B. avium specific genes, 16s rDNA PCR, carbohydrate utilization tests, and complete genome sequencing of a few strains. Out of ~100 isolates tested, 14 yielded contradictory …
Development Of A Survey To Examine The Association Between Relationship Status And Human Papillomavirus Vaccination Behavior, Ansley Waters
Development Of A Survey To Examine The Association Between Relationship Status And Human Papillomavirus Vaccination Behavior, Ansley Waters
Senior Honors Projects, 2010-2019
Literature: HPV is the most prevalent STI in the United States. Although a vaccine to prevent HPV infection exists, only 49.5% of females were up-to-date on the recommended vaccination HPV vaccination series in 2016. Though recommended for younger individuals, there is a catch-up period for females ages 18-26, which shows consistent under-participation. One potential risk factor for non-vaccination may be relationship status. Unlike other sexual health issues where monogamous, long-term relationships serve as a protective factor, such relationships may negatively impact HPV infection risk perception. Building from previous qualitative research, this study examined the quantitative association between relationship status and …
Rat Hind Limb Nociceptive Withdrawal Response To Heat And Mechanical Stimuli Depends On Initial Position Of The Paw But Not Stimulus Location, Giavanna Verdi
Rat Hind Limb Nociceptive Withdrawal Response To Heat And Mechanical Stimuli Depends On Initial Position Of The Paw But Not Stimulus Location, Giavanna Verdi
Senior Honors Projects, 2010-2019
Mammals rapidly withdraw their hind limb in response to noxious stimulation, which is a protective movement known as the nociceptive withdrawal response (NWR). The NWR has been previously studied in spinalized, decerebrated and anesthetized non-human and human mammals; however, there is minimal information on the NWR in intact, unanesthetized non-human mammals.
The first specific aim was to identify the factors that determine the direction and magnitude of the NWR in intact, unanesthetized rats. Based on previous studies, we hypothesized that the location of stimulation and the initial position of the paw preceding the NWR will influence the direction and magnitude …
Characterization Of Neuronal Specific Responses To Induced Misfolded Protein Stress In Caenorhabditis Elegans, Claire Gormley
Characterization Of Neuronal Specific Responses To Induced Misfolded Protein Stress In Caenorhabditis Elegans, Claire Gormley
Senior Honors Projects, 2010-2019
Abstract
Misfolded protein stress has been associated with many types of disease,
including neurodegenerative disorders like Alzheimer’s, Parkinson’s and Huntington’s
disease. When a cell accumulates misfolded proteins in the endoplasmic reticulum,
misfolded protein stress occurs and the unfolded protein response (UPR) is triggered to
induce mechanisms that will allow the cell to either survive or undergo cell death. The
nascent polypeptide associated complex (NAC) is a co-translational chaperone and α/β
heterodimer that manages protein folding and localization, and protects against misfolded
protein stress; changes in NAC function have been linked to both neurodegeneration and
cancer. In these studies, I depleted …
Outcomes And Solutions For Children And Families Affected By Type 1 Diabetes Mellitus, Melissa A. Gray
Outcomes And Solutions For Children And Families Affected By Type 1 Diabetes Mellitus, Melissa A. Gray
Senior Honors Projects, 2010-2019
Caring for children with chronic medical conditions, such as type 1 diabetes mellitus (T1DM) has negative implications for the psychosocial wellbeing of the family. Through this project, the negative affects of T1DM on the family were addressed by the formation of the Life’s Too Sweet: A Workshop for a Brighter Future With Type 1 Diabetes (LTS) event, which creates community support for affected families. During LTS workshops, parents collaborated with each other, while the children participated in fun, educational activities about nutrition, fitness, and overall health in relation to T1DM. Supporting interdisciplinary professionals, such as nurses, social workers, registered dietitians, …
Role Of Interleukin-3 In An Experimental Model Of Mouse Cerebral Malaria Caused By Plasmodium Berghei Anka, Brendon R. Perry
Role Of Interleukin-3 In An Experimental Model Of Mouse Cerebral Malaria Caused By Plasmodium Berghei Anka, Brendon R. Perry
Senior Honors Projects, 2010-2019
Malaria is a life-threatening mosquito-borne disease caused by parasites of the genus Plasmodium, with about 200 million new cases reported each year. In rodent models of malaria, a variety of immune proteins called cytokines have been noted to either promote or suppress protective immunity. While the cytokine interleukin-3 (IL-3) clearly promotes host defense against some intestinal nematode parasites, few studies have reported a similar function for IL-3 in the pathophysiology of malaria. In this study, we investigated the role of IL-3 in a mouse model of cerebral malaria caused by Plasmodium berghei ANKA. We infected wild-type (WT) and IL-3 …
Parents Of Children With Arthritis-Related Diseases: An Examination Of Knowledge Of And Participation In Select Support Programs And Services Offered By The Arthritis Foundation, Margo B. Deihl
Senior Honors Projects, 2010-2019
The purpose of this pilot study was to identify the knowledge of and participation in select Arthritis Foundation support programs and services among parents of children with arthritis-related diseases. Parents attending the 2014 Juvenile Arthritis National Conference in Keystone, Colorado completed an online survey that asked about their knowledge of and participation in these programs. The data collected for the study was quantitative and qualitative. Respondents were given the opportunity to add comments to some survey items, and these items were analyzed by grouping them according to common themes. Results indicated that the parents were more knowledgeable about the Juvenile …
Evaluation Of Interleukin-3 In Blood-Stage Immunity Against Murine Malaria Plasmodium Yoelii, Haley E. Davis
Evaluation Of Interleukin-3 In Blood-Stage Immunity Against Murine Malaria Plasmodium Yoelii, Haley E. Davis
Senior Honors Projects, 2010-2019
Malaria is a mosquito-borne infection caused by the parasitic protozoan Plasmodium. This disease infects over 200-300 million people and causes nearly 400,000 deaths every year. Our laboratory previously examined malarial infection caused by Plasmodium berghei NK65, a lethal rodent strain that induces symptoms similar to those observed in humans. The results of this previous study indicated that the hematopoietic growth factor and immunoregulatory cytokine interleukin-3 (IL-3) suppressed protective immunity against infection with P. berghei NK65. However, the extent to which IL-3 contributes to host defense against blood-stage malaria infection caused by other Plasmodium species remains to be determined. In …
The Medical Response To The Black Death, Joseph A. Legan
The Medical Response To The Black Death, Joseph A. Legan
Senior Honors Projects, 2010-2019
This paper discusses the medical response to the Black Death in both Europe and the Middle East. The Black Death was caused by a series of bacterial strands collectively known as Yersinia pestis. The Plague originated in the Mongolian Steppes. It was spread westward by the east-west trading system. Once it arrived in the Crimea in 1346, Italian merchants helped spread it throughout the Mediterranean. Medicine in Europe and the Middle East were centered on Galen’s theory of humors. There were many religious explanations for the Plague, but the main medical explanation was the spread of bad air, or …
Structural Studies Of The Ig58 Domain Of The Giant Muscle Protein Obscurin, Matthew C. Oehler
Structural Studies Of The Ig58 Domain Of The Giant Muscle Protein Obscurin, Matthew C. Oehler
Senior Honors Projects, 2010-2019
Obscurin (720-900 kD) is a giant sarcomeric signaling protein that is the only known link
between the cytoskeleton and the surrounding membrane structure. Mutations to obscurin
and to obscurin binding partners have been linked to human muscle diseases such as
hypertrophic cardiomyopathies and muscular dystrophy. These diseases likely occur due
to the abrogation of specific molecular interactions necessary for suitable function. To
more fully understand how specific mutations lead to disease, here we solve the highresolution
structure of obscurin Ig58. The literature shows that an Arg8Gln mutation to
the Ig58 domain of obscurin is associated with hypertrophic cardiomyopathy (HCM).
Chemical …