Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Actionable mutations (1)
- Biomarkers, Tumor (1)
- Child (1)
- Child, Preschool (1)
- Children (1)
-
- Female (1)
- Hepatoblastoma (1)
- High-Throughput Nucleotide Sequencing (1)
- Humans (1)
- Immunohistochemistry (1)
- Infant (1)
- Liver Cancer (1)
- Liver Neoplasms (1)
- Male (1)
- Mutation (1)
- Neoplasm Proteins (1)
- Neoplasms (1)
- Next generation sequencing (1)
- Pediatric cancer (1)
- Pediatrics (1)
- Pilot Projects (1)
- Precision Medicine (1)
- Precision medicine (1)
- Retrospective Studies (1)
Articles 1 - 2 of 2
Full-Text Articles in Diseases
Precision Medicine In Pediatric Cancer: Current Applications And Future Prospects., Atif Ahmed, Divya S. Vundamati, Midhat S. Farooqi, Erin M. Guest
Precision Medicine In Pediatric Cancer: Current Applications And Future Prospects., Atif Ahmed, Divya S. Vundamati, Midhat S. Farooqi, Erin M. Guest
Manuscripts, Articles, Book Chapters and Other Papers
Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Pediatric tumors have a different genetic make-up, with a fewer number of actionable targets than adult tumors. Nevertheless, precision oncology in the pediatric population has greatly improved the …
A Brief Report Of Immunohistochemical Markers To Identify Aggressive Hepatoblastoma., Vivekanand Singh, Michelle Manalang, Meenal Singh, Udayan Apte
A Brief Report Of Immunohistochemical Markers To Identify Aggressive Hepatoblastoma., Vivekanand Singh, Michelle Manalang, Meenal Singh, Udayan Apte
Manuscripts, Articles, Book Chapters and Other Papers
Hepatoblastoma (HB) is the most common malignant liver tumor in children. Although survival of patients has improved significantly over the last 2 decades, a significant number of patients do not respond to standard chemotherapy. We conducted a pilot study to understand if there was immunophenotypic difference between tumors that respond well to chemotherapy versus that do not. We selected 10 cases of HB from children presenting at our hospital. All patients had initial tissue diagnosis, underwent chemotherapy followed by surgical resection. The cases were divided into 2 groups: aggressive group with 5 cases (all of which had a poor response …