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Full-Text Articles in Diseases
Role Of Interleukin-3 In An Experimental Model Of Mouse Cerebral Malaria Caused By Plasmodium Berghei Anka, Brendon R. Perry
Role Of Interleukin-3 In An Experimental Model Of Mouse Cerebral Malaria Caused By Plasmodium Berghei Anka, Brendon R. Perry
Senior Honors Projects, 2010-2019
Malaria is a life-threatening mosquito-borne disease caused by parasites of the genus Plasmodium, with about 200 million new cases reported each year. In rodent models of malaria, a variety of immune proteins called cytokines have been noted to either promote or suppress protective immunity. While the cytokine interleukin-3 (IL-3) clearly promotes host defense against some intestinal nematode parasites, few studies have reported a similar function for IL-3 in the pathophysiology of malaria. In this study, we investigated the role of IL-3 in a mouse model of cerebral malaria caused by Plasmodium berghei ANKA. We infected wild-type (WT) and IL-3 …
Evaluation Of Interleukin-3 In Blood-Stage Immunity Against Murine Malaria Plasmodium Yoelii, Haley E. Davis
Evaluation Of Interleukin-3 In Blood-Stage Immunity Against Murine Malaria Plasmodium Yoelii, Haley E. Davis
Senior Honors Projects, 2010-2019
Malaria is a mosquito-borne infection caused by the parasitic protozoan Plasmodium. This disease infects over 200-300 million people and causes nearly 400,000 deaths every year. Our laboratory previously examined malarial infection caused by Plasmodium berghei NK65, a lethal rodent strain that induces symptoms similar to those observed in humans. The results of this previous study indicated that the hematopoietic growth factor and immunoregulatory cytokine interleukin-3 (IL-3) suppressed protective immunity against infection with P. berghei NK65. However, the extent to which IL-3 contributes to host defense against blood-stage malaria infection caused by other Plasmodium species remains to be determined. In …