Diseases Commons^™

The Protective Effects Of Anthocyanins On Differentiated Sh-Sy5y Cells, Abigail F. Lynn

Honors Program Projects

Background

Parkinson’s and Alzheimer’s are debilitating neurodegenerative diseases that are largely thought to be exacerbated, and perhaps even caused by oxidative stress in and around neurons. Green tea is known to contain various nutrients that reduce oxidative stress. Anthocyanins are group of nutrients that are found in plants that have red, purple, or black fruit. They have been shown to directly reduce oxidative stress and may also affect the activity of enzymes such as catalase that reduce oxidative stress. Oxidative stress can be simulated by LPS and D-galactose (DG), sugars that are commonly found on pathogens. SH-SY5Y cells are neuronal …