Diseases Commons^™

Quantifying The Heterogeneity Of The Immunoglobulin G N-Glycome In An Ageing Australian Population: The Busselton Healthy Ageing Study, Alyce Russell

Theses: Doctorates and Masters

The use of immunoglobulin G N-glycomics to study chronic non-communicable disorders and other complex phenotypes emerged following the Human Genome Project. The consortium discovered that most phenotypes were too complex to be explained by genetics alone. Thus, the biological importance of epigenetics was recognised; heritable modifications to gene expression rather than the genome itself. Nglycosylation is a form of epigenetic regulation known as a post-translational modification. It stabilises the immunoglobulin G structure and alters downstream responses elicited by the antibody and is extensively studied as a candidate biomarker in the post-genomic era.

The N-glycosylation of immunoglobulin G itself is complex, …

A Narrative Analysis Of The Experiences Of Living With Hiv For Heterosexual Men, Tanya Millard

Theses : Honours

The number of heterosexual men presenting with Human Immunodeficiency Virus (HIV) is steadily increasing in Australia. A paucity of literature currently exists surrounding the experience of living with HIV for heterosexual men, with most information targeted towards gay men, injecting drug users (IDUs) and women. This narrative literature review examines the body of knowledge concerning the experiences of heterosexual men living with HIV. The findings of this review indicate that for heterosexual men, HIV significantly impacts on their physical, psychological and social well being. In particular, they struggle with social and intimate relationships, negotiating disclosure, managing their stigmatised identity, and …

Networks And Narratives: An Exploration Of Their Relationship And Potential For Understanding The Actual Experiences Of Women With Hiv/Aids, Purity N. Irungu

Theses: Doctorates and Masters

This study set out to examine literature relating to social network theory and narrative theory in order to explore how their potential connection could be used in future to understand and improve the actual life-experiences of women infected by the Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS). The thesis was done entirely by library research using secondary sources but is original in its intent. It includes a critical examination of some of the work of earlier researchers, including Lockhart's (2000) anthropological study of the social construction of `risk' of AIDS in urban Tanzania. Much previous research studied …

Issues That Concern Prison Officers About Hiv Positive Prisoners In Western Australia, David Francis Cain

Theses : Honours

In 1988 the Department of Corrective Services established an AIDS Standing Committee to draw up an HIV positive/AIDS policy. The Committee consists of ten members, two of whom are union members who represent the issues that concern 1,227 prison officers statewide. The Policy which was issued in 1989 medically isolated HIV positive prisoners from the mainstream prison population. The aim of this research is to identify and quantify the issues that concern prison officers about HIV positive prisoners in Western Australia. Such information will act as a medium through which these will be communicated to the AIDS Standing Committee. Structured …

Mathematical Transmission Model Of The Spread Of Hiv Through Sexual Contact And Iv Drug Usage Among Heterosexuals In Western Australia, B. Glockner

Theses : Honours

The human immunodeficiency virus (HIV) and its latter stage, the acquired immune deficiency syndrome (AIDS), are still a major health problem in the world and the full extent of the epidemic is unknown. The HIV virus in Australia has been spread mainly through homosexual contact, but this mode of transmission is decreasing while transmission from heterosexual contact and from IV drug use is increasing. The proposed mathematical model concentrates on transmission of the HIV virus through heterosexual contact and IV drug use among heterosexuals in Western Australia. The model parameters will be estimated from surveys conducted by the Australian National …