Diseases Commons^™

Decision-Making In Ryan White Care Act Planning Bodies: An Analysis Of The Decision-Making Process Of The Joint Committee Of The Jacksonville Hiv/Aids Planning Council And Consortium, Andrea Clarkson Davis

UNF Graduate Theses and Dissertations

The purpose of this study was to determine which factors and the degree to which these factors influenced the Joint Committee when deciding how much money should be allocated to the different services funded by the Ryan White CARE Act. This study focused on the possible explicit and implicit factors influencing the decision-making process and interactions of the members of the HIV/AIDS Joint Prioritization & Allocation Committee in the decisions that were being made on behalf of the people who are infected and affected by this disease.

The methodology included a combination of quantitative and qualitative data, utilizing surveys, coding …

Viral Shedding And Biodistribution Of G207, A Multimutated, Conditionally Replicating Herpes Simplex Virus Type 1, After Intracerebral Inoculation In Aotus, T. Todo, F. Feigenbaum, S. Rabkin, F. Lakeman, J. Newsome, P. Johnson, E. Mitchell, Daniel Belliveau, J. Ostrove, R. Martuza

Daniel J. Belliveau

G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that is currently in clinical trial for patients with malignant glioma. G207 exhibits an efficient oncolytic activity in tumor cells, yet minimal toxicity in normal tissue when injected into the brains of HSV-susceptible mice or nonhuman primates. In this study, we evaluated the shedding and biodistribution of clinical-grade G207 after intracerebral inoculation (3 × 107 pfu) in four New World owl monkeys (Aotus nancymae). Using PCR analyses and viral cultures, neither infectious virus nor viral DNA was detected from tear, saliva, or vaginal secretion samples at any time …