Open Access. Powered by Scholars. Published by Universities.®

Diseases Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 2 of 2

Full-Text Articles in Diseases

Aids Education On College Campuses, Lauretta A. Dienberg Jan 1998

Aids Education On College Campuses, Lauretta A. Dienberg

Graduate Research Papers

Many researchers have examined the issue of college students and AIDS. Most have come to the same conclusion, that students know how to protect themselves but don't see AIDS as personal threat to their lives. As colleges become more diverse and more students are able to attend college, these issues probably will become more complex. Coupled with diversity issues, AIDS has now become known as a chronic rather than deadly disease, as a result of progress made toward treating AIDS and through early detection.


Autocrine Hepatocyte Growth Factor Provides A Local Mechanism For Promoting Axonal Growth, X. Yang, J. Toma, S. Bamji, Daniel Belliveau, J. Kohn, M. Park, F. Miller Dec 1997

Autocrine Hepatocyte Growth Factor Provides A Local Mechanism For Promoting Axonal Growth, X. Yang, J. Toma, S. Bamji, Daniel Belliveau, J. Kohn, M. Park, F. Miller

Daniel J. Belliveau

In this report, we describe a novel local mechanism necessary for optimal axonal growth that involves hepatocyte growth factor (HGF). Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor, the Met tyrosine kinase, both in vivo and in vitro. Exogenous HGF selectively promotes the growth but not survival of cultured sympathetic neurons; the magnitude of this growth effect is similar to that observed with exogenous NGF. Conversely, HGF antibodies that inhibit endogenous HGF decrease sympathetic neuron growth but have no effect on survival. This autocrine HGF is required locally by sympathetic axons for optimal growth, as …