Periodontics and Periodontology Commons^™

Effect Of Passive Tobacco Smoking Exposure On The Periodontal Status Of Turkish Children, Raif Alan, Onur Gezgi̇n, Emre Korkut, Şükriye Türkoğlu, Esra Çeli̇k, Seyfullah Hali̇loğlu

Journal of Dentistry Indonesia

Objective: This study aimed to assess the effect of passive tobacco smoking (PTS) through the comparison of the periodontal status and the C-reactive protein (CRP) and cotinine levels in the biologic fluids in children who are exposed and unexposed to PTS. Methods: A total of 148 participants, whom had smokers (PTS-exposed, n=82) and non-smokers (PTS-unexposed, n=66) in their families, respectively, were included in the study. Gingival index, plaque index, probing depth, and bleeding on probing were recorded. Moreover, saliva, urine, and gingival crevicular fluid samples were collected. CRP and cotinine levels in the biological fluids were determined by …

Transcriptomic Phases Of Periodontitis Lesions Using The Nonhuman Primate Model, Jeffrey L. Ebersole, Radhakrishnan Nagarajan, Sreenatha Kirakodu, Octavio A. Gonzalez

Dental Medicine Faculty Research

We used a nonhuman primate model of ligature-induced periodontitis to identify patterns of gingival transcriptomic after changes demarcating phases of periodontitis lesions (initiation, progression, resolution). A total of 18 adult Macaca mulatta (12–22 years) had ligatures placed (premolar, 1st molar teeth) in all 4 quadrants. Gingival tissue samples were obtained (baseline, 2 weeks, 1 and 3 months during periodontitis and at 5 months resolution). Gene expression was analyzed by microarray [Rhesus Gene 1.0 ST Array (Affymetrix)]. Compared to baseline, a large array of genes were significantly altered at initiation (n = 6049), early progression (n = 4893), and late progression …

B13: The Cd5 Coreceptor’S Effect On T Cell Proliferation In Periodontal Disease, Yuko Sperry

Annual Research Symposium

No abstract provided.

Periodontitis As A Potential Risk Factor For Premature Delivery, Ana Turcu-Duminică, Anca Silvia Dumitriu, Stana Paunica, Corina Gică, Radu Botezatu, Nicolae Gică, Gheorghe Peltecu, Anca Maria Panaitescu

Journal of Mind and Medical Sciences

Pregnancy is a particular period of time for a woman, so that it is important to accurately determine the impact of adjacent pathologies on the natural evolution of the nine months of pregnancy. Although there is still much to debate on the association between periodontal disease and pregnancy, the conclusion seems to remain the same: untreated periodontal pathology in pregnancy could have adverse consequences such as premature birth or low birth weight fetuses. Periodontopathies are introduced as risk factors, the novelty of the subject being the association between untreated periodontal pathology and the evolution of pregnancy. The affected periodontal tissue …

Immediate And Early Loading Of Hydrothermally Treated, Hydroxyapatite-Coated Dental Implants: A 7-Year Prospective Randomized Clinical Study, Afarin Arghami, David Simmons, Jeanne St Germain, Pooja Maney

School of Dentistry Faculty Publications

Background Existing research on marginal bone stability around hydroxyapatite (HA)-coated implants often lacks adequate long-term follow-up. The purpose of this randomized prospective study was to evaluate the 7-year outcome of patients with immediate and early loaded single-tooth restorations supported by implants with plasma-sprayed, partially HA-coated surfaces. Forty-two patients in need of 50 single implants were treated in in the Postgraduate Periodontics Clinic of Louisiana State University School of Dentistry. Implants were randomly divided into 2 groups: Group A was immediately loaded, and Group B was early loaded. Continuous follow-up with periodic maintenance care and radiographic evaluations was performed. The primary …

J Mich Dent Assoc February 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A feature article on “Pediatric Dentistry: Care for Our Youngest Patients in the Challenging Time”.
• A feature article, “The Hall Technique: A Minimally Invasive, Non-aerosol Approach for the Decayed Primary Molar”.
• The feature article, “Delayed Antibiotic Prescribing: A Simple Strategy to Promote Antibiotic Stewardship”.
• ”Dentistry and the Current State of the Opioid Epidemic in Michigan”, …

A Pilot Study: Periodontal Risk Factor Screening Tool For Certified Diabetes Care Education Specialists, Holly Brawner

EWU Masters Thesis Collection

Purpose: There is a bidirectional link between uncontrolled diabetes and untreated periodontal disease. Controlling periodontal infection plays an essential role in the overall management of diabetes. This study explored an interprofessional (IP) collaboration between Certified Diabetes Care and Education Specialists (CDCES) and Dental Hygienists and the utility of a point of care Periodontal Screening Tool (PST) for CDCES to build confidence in informing their clients on periodontal disease risk factors and providing resources to seek dental care.

Methods: This pilot study used a pre-test post-test design where a survey was administered prior to CDCES participating in an Education and Training …

The Impact Of Powered Toothbrushing On Patients With Diabetes, Kristian Ariel Carrasco

EWU Masters Thesis Collection

Purpose: Studies have shown that periodontal therapy can help manage diabetes and that powered toothbrushes promote better home care. However, there is no literature making the connection whether powered toothbrushes could assist in blood glucose management in diabetic patients. The primary aim for this study was to evaluate the efficacy of brushing with a powered toothbrush in patients with diabetes mellitus.

Methods: This clinical study included 8 (N = 8) adult participants from Willamette Dental group in Richland, WA. The individuals were asked to participate in a 6-week study testing whether brushing with a powered toothbrush affected their blood glucose …

S. Gordonii-Produced Hydrogen Peroxide Modulates Mir-663a And Ccl20 Expression In Oral Epithelial Cells, Marshall Houston Maynard

Theses and Dissertations--Medical Sciences

The mechanisms through which a persistent recognition of commensal bacteria by oral epithelial cells (OECs) mitigates an uncontrolled inflammatory response of the oral mucosa remain unknown. CCL20 secretion by OECs in response to pathogenic bacteria is regulated by S. gordonii (Sg)-induced miR-663a; nevertheless, the mechanisms involved in these Sg-modulated responses remain to be elucidated. Since Sg is a hydrogen peroxide (H₂O₂) producer, and H₂O₂ has been shown to stimulate miRNA expression, we hypothesized that H₂O₂ could be involved in Sg-induced miR663a and CCL20 responses. Expression of miR663a …

Effect Of Locally Delivered Melatonin As An Adjunct To Nonsurgical Therapy On Gcf Antioxidant Capacity And Mmp-9 In Stage Ii Periodontitis Patients: A Randomized Controlled Clinical Trial, Enji Ahmed Mahmoud, Olfat Gamil Shaker, Nermin Youssif, Dalia Mohey-Eldien Ghalwash

Dentistry

Objectives. Periodontitis is characterized by inflammatory destruction of periodontal tissue, loss of attachment, and bone resorption. +e increase in reactive oxygen species (ROS) is responsible for the oxidative damage occurring in periodontal tissues. Melatonin has important immunomodulatory, anti-inflammatory, and powerful antioxidant functions. +e current study was carried out to evaluate the effect of topical melatonin gel as an adjunct to nonsurgical periodontal therapy. Methods. +is splitmouth randomized controlled clinical trial was performed on 24 patients with grade II periodontitis. Two sites in each patient were randomly assigned; test sites were treated by nonsurgical therapy followed by intrapocket application of 5% …

Accuracy Of Digital Impressions At Varying Implant Depths: An In-Vitro Study, Vivia Sequeira

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Implants placed at variable depths may vary the amount of visible scannable surface of a scan body. Intraoral scanner technology uses advanced optical principles to record the surface of the scan body to accurately capture the implant position.

Purpose: To investigate the effect implant placement depth has on the accuracy of digital implant impressions using an intraoral scanner.

Materials & Methods: A partially edentulous gypsum master model was fabricated to allow the positioning of a single implant analog at different depths. Four groups based on the planned implant depths of 0, 3, 6 and 7mm and corresponding visibility of …

Expression Of Vascular Endothelial Growth Factor Protein In Mrna-Transfected Human Periodontal Ligament Cells, Mana Naratippakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The complete regeneration of periodontal tissues following current periodontal therapy remain challenging and unpredictable. Nucleoside-modified messenger RNA (mRNA) technology can be a promising novel platform in regenerative medicine. The aims of this study were to evaluate whether pseudouridine modified mRNA encoding vascular endothelial growth factor (VEGF) could induce VEGF production in human periodontal ligament cells (PDLCs) and this translated protein function by promoting in vivo blood vessel formation using chorioallantoic membrane (CAM) assay. Isolated PDLCs from healthy periodontal tissue were transfected with modified mRNA encoding VEGF (VEGF mRNA) complexed with a transfecting agent, Lipofectamine 2000 (L2000) and L2000 alone (control). …

Amixicile, A Novel Antimicrobial Agent, And Its Effect On The Salivary And Subgingival Microbiome In Rhesus Macaque Monkeys, Erin E. Block

Theses and Dissertations

Background/Purpose: Periodontitis is an inflammatory disease with a bacterial etiology in a susceptible host. A selective antibiotic with minimal systemic side effects could be a useful adjunct to traditional periodontal therapy. Amixicile is a novel antimicrobial agent that targets pyruvate: ferredoxin oxidoreductase (PFOR), an enzyme that is critical for anaerobic bacterial metabolism and has been found to have little-to-no side-effects in animal models. The aim of this study was to prospectively evaluate the effect of amixicile on clinical periodontal parameters and the composition of the oral microbiome in rhesus macaque monkeys. It was hypothesized that the amixicile would reduce growth …

Antibiotic-Loaded Dendrimer Hydrogels In Periodontal Bone Regeneration: A Feasibility Study, Nicholas G. Yesbeck

Theses and Dissertations

Purpose: Prescription of a complete course of oral antibiotics following bone grafting procedures is a common clinical practice in surgical periodontics. Prophylactic administration of antibiotics reduces the risk of surgical site infection and systemic administration is preferred over local delivery because of short duration of action in the latter circumstance. The goal of this study is to demonstrate the ability of dendrimer hydrogels (DH) to prolong the release kinetics of antibiotics in-vitro. A secondary goal will be to analyze the effect of different particulate bone allografts on the release kinetics of the antibiotic.

Methods: Dendrimer hydrogels (DH) were synthesized …