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Full-Text Articles in Other Dentistry

Operation Bite Block, Jennifer Aline Robles, Laura Marie Strobbe, William Pearce Graham, Annabelle Katherine Thalken Jun 2026

Operation Bite Block, Jennifer Aline Robles, Laura Marie Strobbe, William Pearce Graham, Annabelle Katherine Thalken

Mechanical Engineering

Current dental bite blocks, or mouth props, are typically manufactured in fixed sizes, and often result in patient discomfort, reduced procedural efficiency, and the need for dental offices to maintain multiple product sizes. This project sought to design, prototype, and validate an adjustable dental bite block capable of accommodating a wide range of patient mouth openings while maintaining comfort, structural integrity, sterilizability, and operator usability. Working in collaboration with Dr. Alan Latta, a practicing dentist in San Luis Obispo, the design process incorporated stakeholder feedback, patent and market research, engineering analysis, and iterative prototyping to develop a solution that addresses …


Evaluation Of Finger-Tightening Torque Applied To Implant Healing Abutments By Dental Providers With Varying Experience And Physical Characteristics: An In-Vitro Study., Bayan Abuhalimeh Jan 2026

Evaluation Of Finger-Tightening Torque Applied To Implant Healing Abutments By Dental Providers With Varying Experience And Physical Characteristics: An In-Vitro Study., Bayan Abuhalimeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Evaluation of Finger-Tightening Torque Applied to Implant Healing Abutments by Dental Providers with Varying Experience and Physical Characteristics: An In-vitro Study

Bayan Abuhalimeh, D.D.S

Aim: The primary objective of this project is to measure the actual torque applied by dental providers when finger-tightening a healing abutment and assess the variability among individuals. A secondary objective is to analyze the correlation between applied torque and: provider experience level (residents, general dentist, specialist); gender; age; and, physical attributes (e.g., grip strength, hand size, and dominant hand used for tightening). The null hypothesis is that there is no difference in the mean finger-tightening …


Endodontic Access Through Zirconia Crowns: A Comparative Evaluation Of 3d Guided Versus Free-Handed Techniques, Maryam Alrughaib Jan 2026

Endodontic Access Through Zirconia Crowns: A Comparative Evaluation Of 3d Guided Versus Free-Handed Techniques, Maryam Alrughaib

Theses and Dissertations

Objective:

Accessing canals through full-coverage zirconia crowns is challenging and may increase the risk of misdirection, excessive dentin removal, and prolonged chair time. Guided endodontic access has been proposed to improve efficiency and precision. This study compared the accuracy and time efficiency of guided versus free-hand endodontic access through zirconia restorations. The hypothesis was that guided access would enhance canal localization precision and significantly reduce access time.

Methods:

Thirty-two extracted maxillary premolars were restored with 1-mm–reduced monolithic zirconia crowns (3Y-TZP, Katana HTML, Kuraray, Japan) and mounted in Modupro models. Teeth were assigned to two groups (n = 16 each): guided …


Posterior Anatomic Limit For Mandibular Molar Distalization In Subjects With Different Growth Patterns, Genders, And Growth Status, Rehana Bashir Dec 2025

Posterior Anatomic Limit For Mandibular Molar Distalization In Subjects With Different Growth Patterns, Genders, And Growth Status, Rehana Bashir

Theses & Dissertations

The objective of this study is to identify the anatomical limits for mandibular molar distalization, a technique frequently employed in orthodontics to address various malocclusions. Mandibular molar distalization plays a critical role in the management of crowding, and correction of the molar relationship.

It is imperative to assess the posterior anatomical space (PAS) in the mandibular retromolar area prior to distalization or uprighting the mandibular molars to avoid periodontal issues (dehiscence, orthodontically induced root resorption, and tooth mobility) and achieve successful treatment outcomes.

A clinical question that, however, isn't well understood is whether the amount of mandibular molar distalization is …


The Effect Of Antemortem Tooth Loss On Craniofacial Shape In Apes And Humans, Ashley R. Laster May 2025

The Effect Of Antemortem Tooth Loss On Craniofacial Shape In Apes And Humans, Ashley R. Laster

Biological Sciences Undergraduate Honors Theses

Antemortem tooth loss (AMTL) (i.e., defined as tooth loss occurring before death) is common among humans and many primates, and several studies have examined AMTL across various primate groups. Some research indicates that AMTL can influence masticatory function and diet; however, the effects of AMTL on craniofacial shape and biomechanics have not been extensively analyzed. We assessed craniofacial and mandibular shape in relation to AMTL, anticipating that individuals with at least one tooth lost antemortem would display significant differences in cranial and/or mandibular shape compared to those without AMTL. AMTL rates were evaluated in three primate species: wild-caught samples of …


Development Of A Streptococcus Mutans Biofilm Model On A Typodont Platform To Investigate Its Dynamics In Orthodontics, Hibah Chughtai Dec 2024

Development Of A Streptococcus Mutans Biofilm Model On A Typodont Platform To Investigate Its Dynamics In Orthodontics, Hibah Chughtai

Theses & Dissertations

Introduction: Biofilm formation plays a significant role in dental health, resulting in plaque accumulation, which can lead to caries and oral diseases. Streptococcus mutans (S. mutans) is a key bacterium involved in this process. The goal of this study was to establish a protocol for the development of an S. mutans biofilm on dental typodont teeth to analyze the effects of orthodontic brackets on biofilm formation. Understanding these dynamics is critical for developing strategies to mitigate biofilm accumulation during orthodontic treatment. Methods: S. mutans biofilms were cultivated under three conditions: 96-well tissue culture plates, S. mutans inoculated non-bracketed …


Investigating The Role Of Ebf3a In Craniofacial Development, Shujan A. Sharafeldeen Jun 2024

Investigating The Role Of Ebf3a In Craniofacial Development, Shujan A. Sharafeldeen

Undergraduate Theses, Capstones, and Recitals

Proper craniofacial development requires many genes. Single-cell RNA sequencing (scRNA-seq) allows us to identify genes expressed in precursor cells for craniofacial structures, but the function of many of these genes in craniofacial development has yet to be characterized. In our scRNA-seq of cranial neural crest cells (NCCs), which are precursor cells for the craniofacial skeleton, we found a gene called early B-cell factor 3 (ebf3a) that may be involved in craniofacial development. In our scRNA-seq data, ebf3a expression is restricted to cranial NCCs of the dorsal and ventral domains of pharyngeal arches 1 and 2. In humans, damaging variants in …


Establishing An Objective, Quantifiable Method For Detecting Erosive Tooth Wear, Camille Kita May 2024

Establishing An Objective, Quantifiable Method For Detecting Erosive Tooth Wear, Camille Kita

Biological Sciences Undergraduate Honors Theses

This study aims to monitor and evaluate erosive tooth wear (ETW) by measurement of enamel surface thickness and texture in a clinical setting. The objective approach is fundamentally different from the standard subjective visual assessment that professionals in the dental field using the Basic Erosive Wear Evaluation (BEWE) method.

Twenty-nine hyposalivation and three control subjects were used in this longitudinal study, for a total of 597 samples (only 577 teeth were eligible for surface texture analysis) evaluated in a longitudinal study including both baseline and 12 month follow up surfaces. Each participant’s buccal surface of the tooth was first analyzed …


Clinical Assessment Of Erosive Tooth Wear Objective Outcome Measures, Elizabeth Wewers May 2024

Clinical Assessment Of Erosive Tooth Wear Objective Outcome Measures, Elizabeth Wewers

Biological Sciences Undergraduate Honors Theses

The purpose of this study was to determine whether enamel surface texture can be used as objective and quantitative measurements to detect and monitor erosive tooth wear (ETW) as an adjunct to the subjective Basic Erosive Wear Evaluation (BEWE) that is commonly used today. This longitudinal observational clinical study enrolled 32 subjects with a sample of n = 584 teeth. Conventional dental microwear surface texture parameters (surface complexity, roughness, and anisotropy - Asfc, Sa, Str, respectively) (were generated using white-light scanning confocal profilometry) from the buccal surfaces of each tooth accepted to the study. I personally scanned and analyzed n …


Comparison Of Specific Jaw Position Measurements On A Static And Dynamic Virtual Patient., Payton Lofton May 2024

Comparison Of Specific Jaw Position Measurements On A Static And Dynamic Virtual Patient., Payton Lofton

Electronic Theses and Dissertations

This study aimed to compared the differences in jaw position measurements in protrusive and open/close positions on a static virtual patient created using 3dMD System to those from a dynamic articulation of a virtual patient (MODJAW) as well as measurements between the Cadiax and MODJAW. Six fiducial surface markers were placed on a volunteer subject’s face and dynamic facial scans of protrusive and open/close jaw movement acquired and exported. A CBCT scan was also acquired. The mandible and maxilla were segmented and loaded into Vultus and aligned to the facial scan using the fiducial markers. Results were compared using a …


Spatial Ability Tests And Course Performance In Human Anatomy And Physiology I Students, Madeline Hinton Apr 2024

Spatial Ability Tests And Course Performance In Human Anatomy And Physiology I Students, Madeline Hinton

Honors Theses

Madeline Hinton: Spatial Ability Tests and Course Performance in Human Anatomy and Physiology I Students

(Under the direction of Dr. Carol Britson)

Visuospatial perception processing is our ability to make inferences about what an object might look like from different angles just by looking at one angle of the object or by looking at a two-dimensional representation of it. This is a skill tested on the perceptual ability portion of the Dental Admissions Test (DAT), and it is also crucial for Human Anatomy and Physiology (HAP) students to be proficient in this skill in order to successfully navigate the organ …


The Effect Of Dental Insurance Coverage And Economic Fluctuations On Oral Health Outcomes In The United States, Laura Singletary Apr 2024

The Effect Of Dental Insurance Coverage And Economic Fluctuations On Oral Health Outcomes In The United States, Laura Singletary

Senior Theses

Proper oral health is imperative to overall health, but obstacles often persist in

receiving proper oral health care. Lack of dental insurance coverage and economic recessions are two main factors contributing to oral health outcomes. Extended time without cleanings or addressing current oral health concerns exacerbates oral health problems into more costly procedures for the patient that are conveniently not covered by many insurance plans. This thesis investigates the oral health outcomes associated with periods following economic downturns, specifically citing the time of the Great Recession from 2007-2009.


Implant Overdenture Abutment Loosening Under Hyperbaric Conditions, Zana Jamal Al-Saloum Jan 2024

Implant Overdenture Abutment Loosening Under Hyperbaric Conditions, Zana Jamal Al-Saloum

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objectives: To investigate the effect of various hyperbaric air pressures on the loosening of LOCATOR® (ZEST Anchors, LLC, Escondido, CA USA) overdenture abutments.

The pressure conditions tested are meant to simulate scuba diving conditions in edentulous patients that are restored with implant-retained tissue-supported overdentures. Another sub-goal of this study is to determine whether or not there is a difference in LOCATOR® loosening when the sample is exposed to six cycles/dives as opposed to one cycle/dive.

Methods: 36 ZimVie Tapered Screw Vent Implants with a 3.5mm diameter implant platform, and a 2.5mm diameter (and 1.5mm deep) internal hexagon were …


The Impact Of Gestational Diabetes Mellitus And Maternal Oral Microbiome: A Scoping Review, Jaclyn P. Langan Jan 2024

The Impact Of Gestational Diabetes Mellitus And Maternal Oral Microbiome: A Scoping Review, Jaclyn P. Langan

Honors Undergraduate Theses

Background: Gestational diabetes mellitus (GDM) is a common pregnancy-related metabolic disorder associated with adverse maternal and fetal outcomes. Recent research has highlighted the potential role of the oral microbiome in the pathophysiology of various systemic conditions, including diabetes mellitus. However, the impact of GDM on the maternal oral microbiome remains relatively understudied. Understanding alterations in the oral microbiome during pregnancy complicated by GDM could provide valuable insights into the mechanistic links between systemic metabolic disorders and oral health.

Objective: The objective of this scoping review was to comprehensively examine the existing literature on the relationship between GDM and maternal oral …


Improving Dental Students' Knowledge And Confidence In Treating Tobacco Use, Victoria Pierce Jan 2024

Improving Dental Students' Knowledge And Confidence In Treating Tobacco Use, Victoria Pierce

DNP Projects

Background: Tobacco use can lead to numerous chronic health conditions. Healthcare professionals in the dental field are in a unique position to broach this issue with patients. Research shows that dental students do not feel equipped to provide tobacco cessation care, citing lack of education on the subject among their top reasons for this.

Purpose: The purpose of this project was to evaluate changes in dental students’ knowledge and confidence related to treating tobacco use after participation in an educational intervention about the 5A’s, behavioral counseling, and first-line prescription medications.

Methods: This quality improvement initiative utilized a quasi-experimental survey design …


Clinical Outcomes Of Primary Anterior Esthetic Crowns In Pediatric Dentistry, Jenan Alahmad Jan 2024

Clinical Outcomes Of Primary Anterior Esthetic Crowns In Pediatric Dentistry, Jenan Alahmad

Theses and Dissertations

Clinical Outcomes of Primary Anterior Esthetic Crowns in Pediatric Dentistry - A Prospective Cohort Study

By: Jenan Alahmad, BDS

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University.

Virginia Commonwealth University, 2024

Thesis Advisor: Parthasarathy Madurantakam, DDS, MDS, PhD

Department of Pediatric Dentistry

BODY

Purpose: This prospective cohort study aimed to compare the effectiveness of restoring maxillary anterior teeth in children (aged 3-6 years) with three different materials: Zirconia Crowns (ZC), Resin Composite Crowns (RC), and Pre-veneered Stainless-Steel Crowns (PVSSC). The study aims to assess the Oral …


Three-Dimensional Analysis Of Condylar Displacement After Orthognathic Surgery In Patients With Facial Asymmetry, Teresa Bae Dec 2023

Three-Dimensional Analysis Of Condylar Displacement After Orthognathic Surgery In Patients With Facial Asymmetry, Teresa Bae

Theses & Dissertations

Facial asymmetry is apparent when there is a clinically significant variation between the two halves of the face. There can be varying degrees of facial asymmetry and mild asymmetry can be treated by orthodontics alone. For severe facial asymmetry a combination of orthodontics and orthognathic surgery may be necessary. The condyle must be in a stable position following surgery to have functional and structural stability and prevent relapse. This research proposal is to perform a retrospective CBCT study on the displacement of the condyle following orthognathic surgery in patients with facial asymmetry. The CBCTs were obtained from Taipei Veterans General …


Impact Of Maximal And Minimal Mouth Opening On Mandibular Flexure Via Scanning, Kangyeong Lim Dec 2023

Impact Of Maximal And Minimal Mouth Opening On Mandibular Flexure Via Scanning, Kangyeong Lim

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Mandibular flexure during mouth opening affects prosthodontic outcomes, but digital scanner research is limited.

Methods: Seventy dental students (35 males, 35 females) had two impressions taken: one with maximum and one with minimum mouth opening.

Results: First molars showed higher deviations than premolars. Females had larger deviations, though not statistically significant.

Conclusion: First molars exhibit greater flexure than premolars.

Keywords: Mandibular flexure, deformation, mouth opening, digital, intraoral scan, three dimensional(3D), prosthetic


Model Minority Myth And Oral Health Disparities In Asian Americans Of Multnomah County In Oregon, Taylor Kang Jun 2023

Model Minority Myth And Oral Health Disparities In Asian Americans Of Multnomah County In Oregon, Taylor Kang

University Honors Theses

This thesis explores the concept of the Model Minority Myth (MMM) and its impact on minority groups such as Asian American communities. It discusses how the MMM is one of the many reasons why health disparities such as oral health disparities, may exist for these groups, particularly in the context of White-majority places like the city of Portland and Multnomah County in Oregon. These disparities, as a result, prevent communities from achieving racial equity in areas such as employment, education, occupation, and income, to name a few. At first glance, the MMM seems to shed an optimistic light with its …


Women In Dentistry At The University Of Mississippi: Increasing The Confidence And Skills Of Future Women Dentists, Lakin Cramer May 2023

Women In Dentistry At The University Of Mississippi: Increasing The Confidence And Skills Of Future Women Dentists, Lakin Cramer

Honors Theses

Women in Dentistry became a registered student organization in February 2022. The purpose of the organization is to encourage and promote the professional and personal success of women in dentistry on the University of Mississippi Oxford campus. The historical and current literature of Women in Dentistry serve to provide a framework for the importance of uplifting women as they prepare for a career in dentistry. During my time as Founder and President of Women in Dentistry, my goal was to establish the organization, provide mentorship to prospective female dental school applicants, and increase the confidence and skills of future women …


Molar Macrowear As A Proxy For Age In A Captive Sample Of Papio Hamadryas, Lauren Conrad May 2023

Molar Macrowear As A Proxy For Age In A Captive Sample Of Papio Hamadryas, Lauren Conrad

Biological Sciences Undergraduate Honors Theses

This study is methods-focused, centering around molar crown macrowear and its performance as a proxy for age in a sample of pedigreed, non-human primates. It analyzes the correlation between age-structured variables and molar wear among both males and females in a captive group of baboons. Here, I examined whether wear is significantly correlated with age-related variables (i.e., generations/cohorts) and whether the structure of the “age” dataset differed across wear categories. Because chronological age is unknown, I used documented pedigrees and parent-offspring relationships to group individuals into possible generations. I then used dental development charts to group individuals into cohorts based …


The Effect Of Fluorouracil On Pathogenic And Non-Pathogenic Oral Microorganisms And Microbial Interactions With Preventative Measures: A Preliminary Study, Valeria Ortiz Jimenez, Lynn Lewis Apr 2023

The Effect Of Fluorouracil On Pathogenic And Non-Pathogenic Oral Microorganisms And Microbial Interactions With Preventative Measures: A Preliminary Study, Valeria Ortiz Jimenez, Lynn Lewis

Departmental Honors & Graduate Capstone Projects

Cancer chemotherapy compromises the patient’s oral health through dysbiosis of oral microbiota and increases the prevalence of dental cavities, gingivitis, oral mucositis, and xerostomia. This research aimed to evaluate the effect of a common chemotherapeutic agent, Fluorouracil (5-FU), on certain microorganisms that are common within the oral cavity. Varying concentrations (50 μM, 75 μM and 100μM) of 5-FU were used to simulate the dosage that reaches the oral cavity after intravenous delivery. The microorganisms tested were Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans, Lactobacillus rhamnosus and Streptococcus salivarius. These are some of the most common ones found in the …


An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold May 2022

An Exploratory Look Into The Effects Of Mississippi's Population Decline On Rural Dental Care, Allen Bailey Saffold

Honors Theses

Literature reviews and interviews with dentists working in rural Mississippi counties examined the effects of population decline on rural dental care in Mississippi. With the state’s continual population decline, loss of industry follows a loss of people. Through a cascade of effects, this can further reduce underserved areas’ access to dental care. In order to address the issue of rural Mississippi continuing to be underserved, policies need to be implemented that will make rural practice at least enticing if not desirable.


Dental Students' Perceptions Of Dental Hygienists' Education And Scope Of Practice, Cynthia Metzger May 2022

Dental Students' Perceptions Of Dental Hygienists' Education And Scope Of Practice, Cynthia Metzger

Electronic Theses and Dissertations

Oral health is strongly correlated to systemic health in the United States. Dental professionals play a significant role in addressing the oral health and prevention of disease for populations in the United States. Because many areas in the United States lack access to dental care, the federal government considers dental hygienists part of the solution. It is now paying attention to restrictive dental hygiene scope of practice rules in each state. State dental boards, comprised mainly of dentists, make these rules based on their perception of dental hygienists' lack of education. This study explored fourth-year dental students' perceptions of the …


Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park May 2022

Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

This thesis presents a study of heritability of maxillary dental arch dimensions in a captive baboon colony. Arch dimensions are important subject because they influence the entirety of the craniofacial and masticatory complex. The goal of this study was to quantify the relative genetic influence on arch dimensions and the nature of this influence at different points along the maxillary arcade. Referencing virtual, three-dimensional dental cast scans, widths were measured at different points between the a) maxillary left and right canines, and b) maxillary left and right first molars (M1). Specifically, measurements were taken at the inner (lingual) gingival margin, …


The Influence Of Cbct-Derived 3d-Printed Models On Endodontic Microsurgical Treatment Planning And Confidence Of The Operator, Shreyas Oza, Johnah C. Galicia Sep 2021

The Influence Of Cbct-Derived 3d-Printed Models On Endodontic Microsurgical Treatment Planning And Confidence Of The Operator, Shreyas Oza, Johnah C. Galicia

Orthodontics and Endodontics Theses

Aims Use of 3D printed models in Endodontics has been gaining popularity since the technology to create them became more affordable. Currently, there are no studies that evaluate the influence of 3D models on endodontic surgical treatment planning and on operator confidence. Therefore, aims of this study were to: (i) Determine whether the availability of a 3D printed analogue can influence treatment-planning and operator confidence; and, (ii) Assess which factors of operator confidence are influenced, if any.

Materials and Methods Endodontists were asked to analyze a pre-selected CBCT scan of an endodontic surgical case and to answer a questionnaire that …


The Rates Of Caries Prevalence By Sex And Age From Individuals In St. Mary Graces And East Smithfield Cemeteries, Elizabeth Houston, Joseph Upton May 2021

The Rates Of Caries Prevalence By Sex And Age From Individuals In St. Mary Graces And East Smithfield Cemeteries, Elizabeth Houston, Joseph Upton

Honors Theses

Caries are a common pathology in past and current populations, and because of the close interaction of dentition with diet, archaeologists are able to infer components of a population’s culture from pathology like caries (Lanfranco & Eggers, 2010). Most literature implies that women have higher rates of caries than men because of cultural practices and natural physiological differences which are thought to put women at an increased risk (Lukacs, 2008). Another established trend throughout literature is that caries prevalence tends to increase with age, regardless of sex (Hillson, 2008). We evaluated data from the East Smithfield (1348-1350 AD) and Saint …


Disparities In Oral Health: Socioeconomic Status And Policies To Increase Access To Primary Dental Care, Mckenzie Nutter Dec 2020

Disparities In Oral Health: Socioeconomic Status And Policies To Increase Access To Primary Dental Care, Mckenzie Nutter

Theses/Capstones/Creative Projects

Primary dental care is a patient-centered service consisting of routine dental checkups. The oral cavity is the first point of entrance to the body for many harmful pathogens. Therefore, primary dental care is essential to not only prevent and treat conditions in the mouth, but to also reduce the number of systemic diseases in the rest of the body. However, people with higher incomes or wealth have increased access to primary dental care. People with low socioeconomic status have decreased access to primary dental care, at least in part due to difficulties in paying for separate dental insurance. Disparities in …


Application Of Machine Learning Technologies For Detection Of Proximal Lesions In Intraoral Digital Images: In Vitro Study., Rohit Vadlamani Aug 2020

Application Of Machine Learning Technologies For Detection Of Proximal Lesions In Intraoral Digital Images: In Vitro Study., Rohit Vadlamani

Electronic Theses and Dissertations

Background: Interpretation of bitewing radiographs is influenced by factors such as acquisition parameters (e.g. exposure, type of sensor), clinical technique, visualization (e.g. monitor type and calibration) and the observer (e.g. experience and fatigue bias). We hypothesized that the use of artificial intelligence (AI) will reduce visualization and observer factor in bitewing interpretation and improve diagnostic accuracy. Objective: The purpose of the present study was to evaluate the use of AI in the form of a machine-learning algorithm to detect and quantify proximal lesions compared with human trained observers. Methods: 16,000 anonymized, digital bitewings of patients were hand searched and non-bitewing, …


Potential Of Human Deciduous Periodontal Ligament Stem Cells For Use In Hepatic Lineage And Their Exosome Application On Hepatic Injuries, R. Vasanthan Punitha Jan 2020

Potential Of Human Deciduous Periodontal Ligament Stem Cells For Use In Hepatic Lineage And Their Exosome Application On Hepatic Injuries, R. Vasanthan Punitha

Student Works (2020-2029)

Introduction: Human deciduous periodontal ligament stem cells represent as another source of stem cells from the dental origin. These cells were shown to have multi-potential attributes and also self renewing ability. These easily accessible stem cells candidate could also resolve issues concerning ethical and compatability for the use in regenerative purposes. However, their efficiency towards hepatic lineage differentiation has not been addressed so far. Meanwhile, the main contributor for regenerative properties were supposedly mediated by soluble factors and extracellular vesicles such as exosomes secreted by cells. Objectives: The aims of this study are to isolate, characterize and also to investigate …