Other Dentistry Commons^™

Bridging Oral And Systemic Health: Exploring Pathogenesis, Biomarkers, And Diagnostic Innovations In Periodontal Disease, Max Foroughi, Mahmoud Torabinejad, Nikola Angelov, David M. Ojcius, Keykavous Parang, Marcus Ravnan, Jerika Lam

Pharmacy Faculty Articles and Research

Purpose

This narrative review explores the multifaceted links between periodontal diseases (gingivitis and periodontitis) and systemic health conditions, including cardiovascular disease, diabetes, adverse pregnancy outcomes, Alzheimer’s disease, cancers, rheumatoid arthritis, and respiratory infections. It aims to synthesize evidence on how local oral infections exert systemic effects and evaluate the potential of diagnostic technologies to monitor these interactions.

Methods

This narrative review synthesizes current scientific literature on periodontal disease pathogenesis, focusing on key pathogens (e.g., Porphyromonas gingivalis, Fusobacterium nucleatum) and their roles in driving local and systemic inflammation via virulence factors and microbial dysbiosis. It examines biomarker-based diagnostic approaches …

1st Place Contest Entry: Provisional Patent Research Process, Joshua Goldfaden

Kevin and Tam Ross Undergraduate Research Prize

This is Joshua Goldfaden's submission for the 2018 Kevin and Tam Ross Undergraduate Research Prize, which won first place. He wrote about abrasive chemicals in commercial toothpastes and created a provisional patent to develop a safer alternative.

Joshua is a sophomore at Chapman University, majoring in Biochemistry and Molecular Biology. His faculty mentor is Dr. Yu-An (Peter) Chang.