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Oral Myeloid Sarcoma: Rare Presentation Of Refractory Acute Myeloid Leukemia With Adverse Molecular Profile, Lauren A. Musial, Naomi Ramer Dds

The New York State Dental Journal

Myeloid sarcoma is a rare extramedullary presentation of acute myeloid leukemia and is especially uncommon in the oral cavity. The presence of myeloid sarcoma may be the initial manifestation of an underlying hematolymphoid disorder or may indicate relapsing disease. We report a case of a 48-year-old male with refractory acute myeloid leukemia who presented with a painful, yellow, plaque-like ulceration on the buccal mucosa. Incisional biopsy demonstrated ulcerated squamous mucosa with a dense infiltrate of large, atypical immunoblastic cells admixed with a prominent population of morphologically atypical eosinophils. These findings were consistent with myeloid sarcoma in the context of the …