Oral Medicine Commons^™

Resilience Of Orthodontic Sealants Against Degradation And Microbial Adhesion: A Comparative Study, Michelle X. Cui

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background:

White spot lesions are one of the most common complications encountered during orthodontic treatment. These lesions begin as demineralization of enamel around the appliance due to plaque buildup, resulting in compromised aesthetics. As they continue to develop, white spot lesions progress to cavitation, potentially threatening pulpal vitality, resulting in an increased financial burden for patients. Preventative strategies include patient education, consistent oral hygiene protocols, and the use of fluoride-releasing agents. Orthodontic sealants such as Opal® Seal™ (Ultradent) (OS) and L.E.D. Pro Seal® (Reliance) (PS) have been developed to release and recharge fluoride, thereby reducing the incidence of white spot …

Effect Of Addition Of Metal Oxide Nanoparticles On The Strength Of Heat-Cured Denture Base Resins: Protocol For Systematic Review And Meta-Analysis Of In Vitro Studies, Pragati Kaurani, Amit Hindocha, Amit Porwal, Abhijit Tambe, Carrie Price, Vidhani Goel, Henry Krasner, Jagdish Khubchandani, Kavita Batra

Department of Medical Education Faculty Research

Background: Metal oxide nanoparticle-reinforced polymethyl methacrylate (PMMA) has been shown to improve mechanical properties, such as strength. Different types of metal oxide nanoparticles have been used previously, but the comparative effect on the strength of heat-cured denture base resins remains unclear. Objective: This is a protocol for a systematic review and meta-analysis that will aim to pool evidence to compare and analyze the effects of the addition of different metal oxide nanoparticles, with varied sizes and concentrations, on the strength (flexural, impact, transverse, compressive tensile strength, and fracture toughness) of heat-cured PMMA. In addition, this review aims to analyze methodological …

Gingival Transcriptome Of Innate Antimicrobial Factors And The Oral Microbiome With Aging And Periodontitis, Jeffrey L. Ebersole, Sreenatha Kirakodu, Linh Nguyen, Octavio A. Gonzalez

Dental Medicine Faculty Research

The epithelial barrier at mucosal sites comprises an important mechanical protective feature of innate immunity, and is intimately involved in communicating signals of infection/tissue damage to inflammatory and immune cells in these local environments. A wide array of antimicrobial factors (AMF) exist at mucosal sites and in secretions that contribute to this innate immunity. A non-human primate model of ligature-induced periodontitis was used to explore characteristics of the antimicrobial factor transcriptome (n = 114 genes) of gingival biopsies in health, initiation and progression of periodontal lesions, and in samples with clinical resolution. Age effects and relationship of AMF to the …

Effects Of Vascular Endothelial Growth Factor (Vegf) On Dental Pulp Stem Cells (Dpsc), Cale Forgues, Eric Mullins, Karl Kingsley

Dental Medicine Faculty Research

Dental Pulp Stem Cells (DPSCs) are non-embryonic, mesenchymal stem cells that may have significant potential for therapeutic and regenerative biomedical applications. Studies of DPSC differentiation have demonstrated the potential to form many tissue types, including neural, osteogenic and vascular precursors using cytokines and growth factors, such as Vascular Endothelial Growth Factor (VEGF). Eight previously isolated Dental Pulp Stem Cell (DPSC) isolates were grown in culture and treated with VEGF to evaluate any effects on growth, viability or biomarker expression. Administration of VEGF at 10 ng/mL significantly inhibited growth in two rapidly dividing or rDT DPSC isolates, with no other measurable …