Oral Medicine Commons^™

Prevalence Profile Perceived Stress And Impact On Quality Of Life For Recurrent Aphthous Ulcers: A Cross-Sectional Epidemiological Study In Egypt, Dalia Ghalwash

Dentistry

Recurrent Aphthous Ulcerations (RAU) are among the most frequent oral ulcers with unknown etiology and multiple risk factors. This study assessed the prevalence profile of aphthous ulcers, risk factors, levels of perceived stress, and their impact on quality of life in an Egyptian sample. This study involved screening 4100 individuals from the outpatient clinic, Faculty of Dentistry, The British University in Egypt, and several Egyptian governorates. Patients were subjected to clinical examination and patient interviews for accurate diagnosis and collection of data. The Perceived Stress Scale (PSS) was used to assess levels of perceived stress, and the Oral Health Impact …

Artificial Intelligence Versus Human Dental Expertise In Diagnosing Periapical Pathosis On Periapical Radiographs: A Multicenter Study, Fatma E.A Hassanen, Radwa R. Hussein, Mohamed Riad Elgarhy, Shaymaa Mohamed Maher, Marwa Ezz, Ahmed Hassen, Sherif Heidar, Amr Edress, Asmaa Abou-Bakr

Dentistry

Periapical pathosis in periapical radiographs must be properly diagnosed for the success of endodontic treatment but is often muddled by 2D imaging limitations and subjective interpretation. Artificial intelligence (AI) offers a solution, but whether the diagnostic granularity of AI versus human clinicians in everyday clinical practice has been adequately explored remains to be addressed. The purpose of this study was to evaluate the diagnostic accuracy of ChatGPT-5 in detecting periapical radiographic abnormalities compared with the three-expert consensus reference standard. Methods: In this diagnostic accuracy retrospective study, 270 periapical radiographs were independently read by a large language model (ChatGPT-5) and a …

Prevalence And Oral Hygiene–Related Correlates Of Self-Reported Dentin Hypersensitivity Among Egyptian Adults: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Ahmed Ammar, Shehad Wael, Alhassan Diab

Dentistry

Abstract

Background

Dentin hypersensitivity (DH) is a prevalent clinical condition characterized by pain arising from exposed dentin in response to external stimuli. Despite its clinical relevance, epidemiological data from Egypt and the Middle East remain limited. This study aimed to assess the prevalence, symptom characteristics, and oral hygiene-related correlates of self-reported dentin hypersensitivity among Egyptians adults.

Methods

A cross-sectional questionnaire-based study was conducted among 370 Egyptian adults recruited from multiple governorates between January and August 2025. Data was collected using a structured questionnaire that underwent expert review, pilot testing, and reliability assessment. Information regarding self-reported dentin hypersensitivity, triggering stimuli, oral …

Prevalence Of Oral Mucosal Lesions Among Smokers Based On Gender: A Bicentric Cross-Sectional Study In Egypt, Dalia Ghalwash, Fatheya Zahran

Dentistry

Abstract

Background

Smoking is a major risk factor for developing various types of oral mucosal lesions (OMLs), including benign and potentially malignant lesions. However, scarce data is available concerning gender differences regarding the prevalence of oral mucosal lesions in smokers worldwide. Accordingly, this study assesses the prevalence and types of OMLs among male smokers compared to female smokers in an Egyptian population.

Methods

This hospital-based cross-sectional study included 300 male and 300 female smokers. All participants underwent a thorough case history review and a comprehensive clinical examination.

Results

The overall prevalence of oral lesions was significantly higher in males (75%) …

Dentists’ Acceptance Of Artificial Intelligence-Assisted Decision Support For Oral Potentially Malignant Disorder Detection: A Structural Equation Modeling Study, Dalia Ghalwash

Dentistry

Abstract

Artificial intelligence (AI) may support early detection and clinical decision-making of oral potentially malignant disorders (OPMDs), but clinical implementation depends on dentists’ acceptance of AI-assisted clinical decision support. This study aimed to identify structural associations of AI acceptance among dentists using an extended Technology Acceptance Model (TAM). A cross-sectional survey was conducted among 500 dentists. Construct validity and reliability were assessed using confirmatory factor analysis. Hypothesized associations were evaluated using structural equation modeling with bootstrap mediation analysis. The extended TAM showed generally satisfactory measurement properties and good overall model fit. Attitude toward AI showed the strongest association with behavioral …

When Drug Repurposing Backfires: Antagonistic Effects Of Ivermectin On Cisplatin Therapy In Oral Cancer, Dalia Ghalwash, Rana Tantawy, Shereen Nader, Ayman Elgawish

Dentistry

Abstract

Background

Cisplatin (CIS) remains the gold standard chemotherapeutic agent for the management of oral cancer. However, its clinical efficacy is frequently limited by chemoresistance and dose-dependent toxicities. Ivermectin (IVM), a well-established antiparasitic agent with emerging anticancer properties, has been proposed as a potential adjuvant capable of enhancing the antitumor efficacy of CIS.

Methods

In vitro experiments were conducted on HN9 oral squamous cell carcinoma cells, while OEC normal epithelial cells served as control. The experimental evaluation comprised the MTT assay for cell viability, Annexin V/propidium iodide (PI) staining for apoptosis detection, cell cycle distribution analysis, quantitative real-time PCR (RT-qPCR) …

Prevalence Of Oral Mucosal Lesions Among Geriatric Dental Patients In Egypt: A Cross-Sectional Study, Dalia Ghalwash, Ahmed Hamdy, Sara Abd El-Wahed

Dentistry

Background. The oral health needs of older adults must be prioritized due to the shifting demographics of the population and rising life expectancy. This study investigated the prevalence of oral mucosal lesions (OMLs) among geriatric dental patients in a sample of the Egyptian population and explored the association with age, gender, smoking habit, as well as the impact on the quality of life. Methods. This cross-sectional study screened 300 geriatric dental patients aged 65 years or older, from several dental hospitals and mobile clinics in various regions in Egypt. Demographic data and information regarding denture use, systemic diseases, and smoking …

Impact Of The Adjunctive Use Of Omega-3 In Periodontitispatients With Diabetes On Local And Systemic Chemerin Levels:A Randomized Clinical Trial, Dalia Ghalwash, Ahmed M. Ammar, Ayman El-Gawish, Ahmed Hamdy

Dentistry

Aims: The present study aspired to evaluate the impact of the adjunctive use of omega-3 with nonsurgical periodontal therapy onclinical parameters as well as local and systemic chemerin levels as a marker of cardiovascular disease risk in periodontitis patientswith diabetes.Methods: This randomized clinical trial was performed on thirty periodontitis patients with type II diabetes divided into two equalgroups, both treated by nonsurgical periodontal treatment with the adjunctive use of daily 1000 mg Omega-3FAs in group I onlyfor 6 months. Patients were reexamined after 2 weeks (baseline), 3, and 6 months for recording the clinical parameters as follows:plaque index (PI), gingival …

Perception, Usage, And Concerns Of Artificial Intelligence Applications Among Postgraduate Dental Students Cross-Sectional Study, Dalia Ghalwash, Asmaa Abou-Bakr, Susan Sarhan, Amira Badra, Hadeel Almalahy

Dentistry

Background

Future dental applications of artificial intelligence (AI) are anticipated to be widely adopted across all dental specialities. However, there are some concerns among many users about the accuracy of the given information. Therefore, this study aimed to investigate postgraduate’ dental students’ perception, usage, and concerns towards AI systems’ applications.

Materials and methods

An online self-administered survey, consisting of 19 closed-ended questions in the English language, and a 3-point Likert-type scale was used to obtain a simple and straightforward response from participants in a “forced-choice” response format that was distributed to postgraduate dental students in the faculty of dentistry of …

Oral Cancer Awareness Among Dentists: What Is Missing? A Cross-Sectional Study, Dalia Ghalwash, Fatheya Zahran

Dentistry

Introduction

Oral cancer (OC) is one of the major global health problems with a high incidence rate in developing countries. Early detection can improve the prognosis and survival rate of the disease.

Aim

The current study evaluates dentists’ general awareness, knowledge, attitude, and practice regarding oral cancer.

Methods

In the current cross-sectional study, a self-reported questionnaire was distributed to a sample of dentists in Egypt. A total of 700 dentists participated. The questionnaire included 27 questions on oral cancer knowledge, opinions, attitudes, and practices.

Results

The highest awareness of risk factors concentrated around tobacco and alcohol consumption, and the most …

Efficacy Of Manuka Honey Oral Rinsein Treatment Of Xerostomia Among Elderlypatients: A Randomized Controlled Trial, Dalia Ghalwash, Asmaa Abou-Bakr, Ayman Elgawish

Dentistry

Background Xerostomia is a common complaint among elderly patients. Due to the anti-inflammatory effect, Manuka honey could be a promising alternative remedy for many medical conditions, including xerostomia. The present study aimed to evaluate the effectiveness of Manuka honey oral rinse as a novel management for xerostomiain elderly patients. Methods This study was designed as a randomized, single-blinded clinical trial. 42 elderly patients who were allevaluated for the presence of xerostomia and hyposalivation were randomly allocated into 3 equal groups. The interventions were used 3 times per day for 1 month as follows: Manuka honey oral rinse in group I, …

Evaluation Of Thymoquinone Cancer Chemo-Preventive Effect On Oral Leukoplakia: A Randomized Clinical Trial, Dalia Ghalwash, Fatheya Zahran

Dentistry

Aim: This randomized clinical trial aimed to investigate the chemo-preventive role of thymoquinone in Nigella sativa extract in managing oral leukoplakia clinically, histologically, and at the molecular level. Methods: A total of 48 patients with oral leukoplakia were randomly allocated to three groups; Group A received local muco-adhesive tablets with Nigella sativa extract in 10 mg/kg dose, for three months, Group B same intervention but with Nigella sativa extract in 5 mg/kg dose, and lastly Group C was the placebo group. The outcomes assessed were clinical improvement, histologic improvement (degree of dysplasia), and molecular biomarkers Ki-67 and caspase-3 by immunohistochemistry. …

Prevalence And Impact Of Xerostomia On Quality Of Life: A Clinical-Based Cross-Sectional Study In Egypt, Dalia Ghalwash, Ayman Elgawish, Asmaa Abou-Bakr

Dentistry

Background The current investigation aimed to assess the prevalence of xerostomia, its relation to risk factors, and its impact on the quality of life among a sample of the Egyptian population.

Methods This cross‑sectional study collected data on the occurrence of xerostomia and risk factors from 1220subjects in several Egyptian governorates, including sex, age, smoking, systemic illness, and medications. Subjective and objective dry mouth scores, taste disturbances, burning sensations, and their impact on quality of life were assessed.

Results Xerostomia was estimated to involve 49.6% of the studied population. It was found to increase with ageand was substantially higher amongst …

Epidemiology Of Recurrent Herpes Labialis Among Dentistry Students: A Cross-Sectional Survey In Egypt, Sara Abdelwahed, Dalia Ghalwash, Al Hassan Diab

Dentistry

Aim: Recurrent herpes labialis (RHL) is a common viral infection with significant psychosocial and clinical implications. Dental students are particularly vulnerable due to stress and frequent patient contact, yet data on their epidemiology in Egyptian cohorts are scarce. The study aimed to determine the prevalence, recurrence patterns, and associated risk factors of RHL among dentistry students in Egypt. Materials and Methods: A cross-sectional survey was conducted among 559 dentistry students at the British University in Egypt. A structured, self-administered questionnaire captured sociodemographic data, history of RHL episodes, frequency, severity, and triggering factors. Data were analyzed using descriptive statistics and Chi-square …

Synergistic Potential Of Ivermectin And Doxorubicin In Oral Squamous Cell Carcinoma: An In Vitro Investigation, Dalia Ghalwash, Shereen Nader, Rana Tantawy

Dentistry

Background Doxorubicin (DOX) is widely used in cancer therapy, but its role in oral squamous cell carcinoma (OSCC)is limited by resistance and dose-related toxicities. Ivermectin (IVM), an antiparasitic agent with emerging anticancer properties, may enhance DOX efficacy. This study evaluated the effects of IVM alone and in combination with DOX on OSCC cell lines.

Methods In vitro assays, including MTT viability, apoptosis (Annexin V/PI), cell cycle analysis, RT-qPCR of apoptotic, proliferative, and inflammatory markers, and oxidative stress assays, were performed on HN9 and HEp-2 OSCC cell lines, with OEC as control.

Results IVM reduced cancer cell viability in a dose-dependent …

Epidemiology Of Sjogren’S Syndrome In A Sample Of The Egyptian Population: A Cross-Sectional Study, Dalia Ghalwash, Ahmed M. Ammar, Ahmed Hamdy, Ayman Elgawish, Rim Mazen

Dentistry

Objective: To investigate the prevalence of Sjogren’s syndrome (SS) and the associated factors in € a sample of the Egyptian population. Methods: This cross-sectional study obtained data by screening subjects from several hospitals in different governorates across Egypt. Demographic and health data were collected including symptoms and type of Sjogren’s syndrome, associated autoimmune diseases, the presence of € specific autoantibodies and associated malignancies. Results: The study analysed 7960 participants and 64 (0.80%) had SS. Of these, 22 (34.38%) had primary SS and 42 patients (65.63%) had secondary SS. For the total study cohort, the prevalence of primary and secondary SS …

Prevalence Profile Of Burning Mouth Syndrome In A Sample Of Egyptian Population: A Cross-Sectional Clinical Based Study, Dalia Ghalwash, Ahmed M. Ammar, Ahmed Hamdy, Ayman Elgawish

Dentistry

Aim: Burning mouth syndrome (BMS) is a debilitating chronic burning sensation in the oral cavity with no identifiable cause. The present research was conducted to evaluate the prevalence profile of BMS in a sample of the Egyptian population. Methods: A cross-sectional study was performed by screening 952 subjects, all individuals with burning mouth complaints were interviewed and examined to identify the site, timing, frequency, and intensity of their burning sensations. The presence of associated xerostomia, taste disturbances, and impact on quality of life was also recorded. The extent of perceived stress was assessed using the short version of the Perceived …

Comorbidities And Final Outcome Of Post Covid-19 Associated Oral Mucormycosis Patients: A Cross-Sectional Study, Dalia Ghalwash, Asmaa Abou-Bakr, Ayman El-Gawish

Dentistry

Background

Mucormycosis is an invasive and possibly fatal fungal infection that frequently affects the mouth. Co-infection in post COVID-19 patients is an emerging concern, owing to their complex nature and higher mortality. Therefore, this study aimed to report the underlying risk factors, clinical characteristics, presentation, and final outcome of COVID-19 associated oral mucormycosis cases.

Results

This study included 51 patients with oral mucormycosis 28 (55%) males and 23 (45%) females. Twenty-three patients (45%) presented with deep necrotic ulcer, 16 patients (31%) presented with superficial ulcer, and 12 patients (23%) of them presented with fistula. The overall survival rate was 51% …

Dysplasia In Oral Lichen Planus In A Sample Of Egyptians Attending 2 Tertiary Care Centers In Cairo, Dalia Ghalwash, Ayman El-Gawish

Dentistry

The present retrospective study aimed to evaluate dysplastic changes in oral lichen planus (OLP) lesions and related risk factors in a sample of Egyptians. The records of patients with histological diagnosis of OLP, who attended the Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, and Faculty of Dentistry, the British University in Egypt, in the period from 2020 to 2023 were used. The frequency of dysplasia was 10.19% and was statistically not associated with age, gender or smoking. Our results showed that the erosive type registered the highest rate (p<0.001), followed by atrophic, whereas papular type did not show dysplasia. Also, the most common site for dysplasia was the buccal mucosa and tongue (p<0.001 and p=0.001, respectively), then gingiva, lips, and floor of the mouth. Given the importance of OLP, among the Egyptian population seeking care in our clinics, more research should be conducted to create a database of statistical information.

https://doi.org/10.1111/odi.151

Systemic Versus Local Injection Of Bone Marrow Mesenchymal Stem Cells On 5-Fluorouracil Treated Parotid Glands Of Albino Rats, Caroline Maged Massieh, Medhat El Zainy, Reham Magdy Amin, Iman Fathy

Dentistry

ABSTRACT Objective: Head and neck cancer is the sixth leading cancer by incidence worldwide and eighth by death. Recent reports revealed that, not only radiotherapy but also chemotherapy may induce xerostomia. The aim of this study was to compare the possible regenerative effect of BMSCs through systemic and local injections. Material and Methods: 52 male Albino rats were randomly divided into 4 groups: Group 1: 10 rats received 0.5 ml of PBS by injection. Group 2: 14 rats received an intraperitoneal injection of 5-FU drug. Group 3: 14 rats were injected the same dose of 5-FU then received an intraglandular …