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Oral Mucositis: The New Paradigms, Rajesh V. Lalla, Douglas E. Peterson
Oral Mucositis: The New Paradigms, Rajesh V. Lalla, Douglas E. Peterson
UCHC Articles - Research
Purpose of review
Mucositis has long been viewed as an unavoidable consequence of high-dose chemotherapy and/or radiation. Management has been directed to supportive care including oral pain control, nutritional support, infection treatment and control of diarrhea. While these interventions have been valuable for clinical management, they have not been collectively directed to molecularly targeted prevention and treatment. This review addresses recent advances regarding mucosal injury in cancer patients, with emphasis on symptom clusters, genetically-based tissue susceptibility and risk prediction, imaging technology, and computational biology.
Recent findings
Modeling of symptom clusters in cancer patients continues to mature. Although integration of mucositis …