Oral Biology and Oral Pathology Commons^™

Expression Of Vimentin, Α-Sma And Tgf-Β In Different Grades Of Oral Squamous Cell Carcinoma, Hala El-Kammar, Waleed F. Esmael, Nermeen S. Afifi

Future Dental Journal

Abstract

Background: Oral Squamous cell carcinoma (OSCC) is typically discovered at an early stage; nevertheless, regional lymph node metastases are prevalent; therefore, surgical excision of the primary tumor is commonly coupled with neck dissection and radiotherapy. Cancer cells become invasive by acquiring a mesenchymal phenotype, a process known as the epithelial-to-mesenchymal transition. Vimentin, α-SMA and TGF-β expressions are believed to take part in EMT and tumor progression. Aim: this work aimed to evaluate the expression of Vimentin, α-SMA and TGF-β on OSCC progression and hence propose potential role as potential prognostic markers or therapeutic targets. Materials and methods: twenty-four specimens …

Therapeutic Effect Of Curcumin, Ginger And Tamarind On Oral And Paraoral Tissues: (Histological Overview), Mona El Deeb, Amany A. Rabea

Future Dental Journal

Background: Biocompatible substances from plant origin have been more in focus in contemporary dentistry. Aim: This review, aimed to highpoint the influence of curcumin, ginger and tamarind on different oral and paraoral tissues from histological point of view. Material and methods: A narrative review was carried out based on publications in PubMed, google and Scopus database. The documents published up to 2021 were included. The research was based on inclusion criteria of 89 studies.Results: Curcumin inhibits alveolar bone resorption, reduces inflammatory cell infiltration, aids in epithelial regeneration and improves salivary glands architecture. Ginger was found to be beneficial in …

Evaluation Of Apoptotic Effect Of Betanin Nanoparticles Against Squamous Cell Carcinoma Cell Line Compared To Doxorubicin, Noha Hassanine Noha.Hassanine@Fue.Edu.Eg, Future University In Egypt, Amany M. Taha Lecturer, Al Azhar University, Egypt, Eman A. Abohager Professor, Al Azhar University

Future Dental Journal

Objective : to evaluate the anticancer effect of nano sized betanine particles (betanine NP) on squamous cell carcinoma cell line compared to doxorubicin (DOX) by measuring apoptosis through caspase 3. Methods: Three groups of the human tongue squamous cell carcinoma cell line (SCC 25) were created, and two of them were treated with DOX and betanine NP. The third group served as a negative control and was not given any treatment. To evaluate the concentration of caspase 3 using the ElISA technology, different quantities of betanin NP and DOX were administered to SCC25 at 48- and 72-hour intervals.Results: …