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Full-Text Articles in Oral Biology and Oral Pathology
Upregulated Mir-146a Expression In Peripheral Blood Mononuclear Cells From Rheumatoid Arthritis Patients, Kaleb M. Pauley, M. Satoh, A. L. Chan, M. R. Bubb, W. H. Reeves, E. K. Chan
Upregulated Mir-146a Expression In Peripheral Blood Mononuclear Cells From Rheumatoid Arthritis Patients, Kaleb M. Pauley, M. Satoh, A. L. Chan, M. R. Bubb, W. H. Reeves, E. K. Chan
Science and Mathematics Faculty Publications
Introduction
MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted mRNAs. It is known that aberrant microRNA expression can play important roles in cancer, but the role of microRNAs in autoimmune diseases is only beginning to emerge. In this study, the expression of selected microRNAs is examined in rheumatoid arthritis.
Methods
Total RNA was isolated from peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis, and healthy and disease control individuals, and the expression of miR-146a, miR-155, miR-132, miR-16, and microRNA let-7a was analyzed using quantitative real-time PCR.
Results …