Dentistry Commons^™

Left Ventricular Global And Regional Deformation In Arrhythmic Myxomatous Bileaflet Mitral Valve Prolapse Syndrome, Lakshmi Muthukumar, Arshad Jahangir, M. Faud Jan, Patrycja Galazka, Matt Umland, Mckenzie R. Schweitzer, Ana Cristina Perez Moreno, Maharaj Singh, Bijoy K. Khandheria, A. Jamil Tajik

School of Dentistry Faculty Research and Publications

No abstract provided.

Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects In Rheumatoid Arthritis, Mahdi Zavvar, Sara Assadiasl, Sina Zargaran, Maryam Akhtari, Behzad Poopak, Rassoul Dinarvand, Yousef Fatahi, Lobat Tayebi, Narjes Soleimanifar, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct …

Synthesis Of Novel Reducing Agent For Formation Of Metronidazole-Capped Silver Nanoparticle And Evaluating Antibacterial Efficiency In Gram-Positive And Gram-Negative Bacteria, Fatemeh Farjadian, Amin Reza Akbarizadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, a new type of silver nanoparticles capped with metronidazolium based ionic liquid is synthesized. By this aim, metronidazole is altered to ionic-liquid type structure with citrate counter ion as reducing agent. The produced reducing agent was characterized using ¹HNMR and ¹³CNMR and FT-IR. The capability of metronidazolium-based reducing agent in formation and capping silver nanoparticles was examined in a chemical reaction. More specifically, synthesized silver nanoparticles were synthesized and capped with metronidazolium-citrate based ionic liquid, while the formation of particles in 48 h was monitored by UV-Vis spectroscopy. Fourier transform infrared spectroscopy showed the presence …

Effect Of Fabrication Method On The Structure And Properties Of A Nanostructured Nickel-Free Stainless Steel, L. Heidari, A. Tangestani, M. J. Hadianfard, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

An ASTM F2581 nanostructured stainless steel was fabricated by two different powder metallurgy routes; Hot Powder Forging (HPF) and Binder Assisted Extrusion (BAE) methods. Their structure and mechanical properties were investigated and compared. In both fabrication methods, the alloy powder was made by using main alloying elements through mechanical alloying, along with the addition of a sintering aid. In the BAE method, a paste was prepared by mixing alloy powders with polymer followed by cold extrusion, polymer removal, and sintering. In the HPF method, the alloy powders were hot forged under high pressure. The structure and the size of the …

Effect Of Dentin Biomodification Delivered By Experimental Acidic And Neutral Primers On Resin Adhesion, Lívia Tosi Trevelin, Yvette Alania, Mathew Mathew, Rasika S. Phansalkar, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin–resin biointerfaces of two highly bioactive PAC-rich extracts, Vitis vinifera (Vv) and Camellia sinensis (Cs), delivered using neutral (NP) or acidic (AP) rinse-out primer approaches.

Methods

The depth of dentin demineralization (optical profilometry), dentin biomodification (apparent modulus of elasticity, collagen auto-fluorescence) and properties of dentin–resin interfaces (microtensile bond strength - μTBS, and micro-permeability) were investigated. NP consisted of either 15% Vv or Cs applied for …

Orthodontic Treatment Combined With Autotransplantation In Adults, I-Ting Chiang, Yi-Horng Chen, Rebecca Chen, Chien-Cheng Chen

Taiwanese Journal of Orthodontics

A 28-year-old female with mild skeletal Class II and dental Class I malocclusion had chief complaint of teeth crowding and poor esthetics. The patient presented with a convex facial profile, long face with a steep mandibular angle, bimaxillary dentoalveolar protrusion with 9 mm overjet, and dental crowding. She had severe caries on the maxillary right first and second molars, and the mandibular left second molar. The mandibular left first and second premolars had ill-fitting porcelain-fused-to-metal crowns. The maxillary right third molar and the mandibular left third molar were impacted. The orthodontic treatment included autotransplantation of the maxillary left first premolar …

Molar Protraction Through Downward Extension Of Maxillary Sinus In Patient With Central Diastema Caused By Small Lateral Incisors, Hsien-Fang Hung, Ming-Chu Huang, Ming-Jeaun Su

Taiwanese Journal of Orthodontics

A 32-year-old male patient presented with upper central diastema resulting from upper bilateral smallsized lateral incisors. The patient also had a deep bite of dental origin. A relatively simple mechanotherapy with pre-adjusted edgewise appliances was applied. A favorable and stable result of the ideal overbite and overjet after the correction of central diastema. Besides the above primary complaints, the prolonged retained roots of upper left first molar caused difficulty for proper space closure since the maxillary sinus wall was downward extended. The lower sinus floor may impede the orthodontic movement, but was very likely to be overlooked. The upper left …

Camouflage Orthodontic Treatment On Skeletal Class Ii Malocclusion With Idiopathic Condylar Resorption, Hsin-Yi Lo, Liang-Ru Chen, Kwong-Wa Li, Ming-Lun Hong

Taiwanese Journal of Orthodontics

Idiopathic condylar resorption (ICR), also known as idiopathic condylysis or condylar atrophy, and progressive condylar resorption (PCR), is a poorly understood progressive disease that affects the temporomandibular joint (TMJ) with multifactorial factors leading to severe mandibular retrognathism and anterior open bite. It is difficult to distinguish the exact causes for each individual. Different diagnostic methods and different treatment options can be chosen for different phases. In this report, we present a camouflage treatment with temporary anchorage devices (TADs) for a skeletal Class II open bite with ICR. The goal of improving facial profile and reconstructing of occlusion was achieved. Comprehensive …

Treatment Options For Obstructive Sleep Apnea, Shao-Chih Hsieh, Szu-Ting Chou, Yu-Chuan Tseng

Taiwanese Journal of Orthodontics

Obstructive sleep apnea (OSA) is sleep-disordered breathing caused by the collapse of the upper airway. Because anatomical abnormalities of the narrow upper airway are undoubtedly the most critical cause of OSA, the available treatment methods for OSA mostly focus on these anatomical problems. The collapse of the respiratory tract is associated with different levels of upper airway obstruction. The obstruction of the airway can be divided into three parts: the nasal cavity, retropalatal region, and retrolingual region. This article summarizes some common OSA treatment methods, their underlying theories, and their effect on the upper airway.

Effects Of Different Occlusion Setups With A Surgery-First Approach And Simulated Presurgical Orthodontics On The Mandibular Position In Skeletal Class Iii Malocclusion, Gloria Shih-Wen Fan, Yu-Chih Wang, Chiung Shing Huang, Ellen Wen-Ching Ko

Taiwanese Journal of Orthodontics

Purpose: The purposes of this study were to compare the occlusion designs implemented for the surgery-first approach (SFA) and the resultant mandibular movements by different orthodontists, as well as to investigate whether presurgical dental alignment is associated with mandibular positioning.
Methods: This prospective study included 15 patients with skeletal Class III malocclusion who underwent orthognathic surgery through the SFA. Three orthodontists designed an occlusion setup for each case, which were assigned as SFA groups. The same group of patients, who received simulated presurgical orthodontics (SPO) through a virtual setup, composed the control group. The postoperative dental relationship and resultant mandibular …

Nonsurgical Correction Of Skeletal Class Iii Malocclusion With Evident Profile Change In An Adult Patient With Functional Shift And Low Mandibular Plane Angle, Ting-Yu Kuo, Chun-Liang Kuo

Taiwanese Journal of Orthodontics

This article reports the successfully utilize the range of functional shift to treat a 16-year-old female with a chief complaint of anterior crossbite. The patient had a skeletal Class III malocclusion with a protrusive mandible, anterior crossbite, low mandibular plane angle and facial asymmetry.

To achieve optimal correction of facial profile and occlusion, orthognathic surgery would be the first treatment option. However, this patient and her family declined the surgical option for higher cost. As a consequence, we use lower anterior bite turbo to disocclude posterior teeth for the posterior teeth extrusion. Class III elastics were applied for the correction …

Non-Surgical Treatment For A Patient With Condyle Head Resorption And Unstable Occlusion, Tsung-Jui Hsieh, Tzu-Ying Wu

Taiwanese Journal of Orthodontics

This case report presents multiple TADs application technique on managing difficult dental and skeletal malocclusion. This 36-year-old female who was diagnosed as rheumatoid arthritis and had been under medication control for 6 years. In addition, she was diagnosed as condyle erosion with bilateral crepitus sound during jaw movement. The characters of occlusion including Class II malocclusion with increased overjet (6 mm), multiple posterior teeth missing and super-erupted teeth 17 and 26, and unstable occlusion. During phase I, patient was referred for occlusal splint treatment, and we followed the progression of condylar condition. At phase II, surgical intervention was suggested but …

Non-Surgical And Non-Extraction Orthodontic Treatment Of An Excess Reverse Bite With Anterior Open Bite, Jung-Chi Hsu, I-Hua Liu, Chun-Liang Kuo, Chun-Hsiu Yang, Yu-Ling Tsai, Chung-Li Wang

Taiwanese Journal of Orthodontics

This 13-year-old female had a severe Angle’s Class III malocclusion with an excessive negative overjet 7 mm, anterior open bite 2 mm, a prognathic chin and a concave lateral profile. But this patient and her parents refused orthognathic surgery. Finally, she was treated with a non-surgical and non-extraction approach. The treatment plan consisted of total distalization of mandibular dentition with bilateral temporary anchorage device (TAD) and maxillary incisor extrusion with vertical elastics. The active treatment period was 34 months. Normal overbite, overjet, and acceptable profile were achieved.

Applications Of Artificial Intelligence In Orthodontics, Hsien-Ching Hung, Yi-Chin Wang, Yu-Chih Wang

Taiwanese Journal of Orthodontics

Artificial intelligence (AI) technology is a tool for finding insights in different kind of information in medical field. The purpose of this article was giving a brief introduction to applications of AI in orthodontic treatment. The reviewed literatures were further categorized into (1) extraction or non-extraction therapy in orthodontic treatment, (2) orthognathic surgery, (3) segmentation and landmark identification, (4) growth prediction, (5) cleft related studies, and (6) TMD classification.

Surgical Methods To Accelerate Tooth Movement, Miao-Jing Chen, Shih-Chieh Chen, Jung-Hsuan Cheng, Yu-Chuan Tseng Dds, Mds, Phd

Taiwanese Journal of Orthodontics

Comprehensive orthodontic treatment usually takes 1–3 years to finish the details. The treatment duration depends on the complexity of treatment. Longer treatment times may increase the risk of root resorption, oral hygiene–related problems such as white spot lesion or dental caries, and periodontal destruction. Several methods, such as surgical-assisted procedures, drugs, and physical/mechanical stimulation methods, may accelerate tooth movement and shortened whole treatment time. This article reviews various surgical-assisted procedures and how the surgical method that can effectively shorten the treatment time. The advantages and disadvantages of various technique were also assessed.

Treatment Efficacy Of Invisalign: Literature Review Update, Meng-Huan Tsai, Stephanie Shih-Hsuan Chen, Yi-Jane Chen, Jane Chung-Chen Yao

Taiwanese Journal of Orthodontics

Purpose: Inconsistency between computer prediction and actual tooth movement in Invisalign treatment always limits clinical judgment. The objective of this review was to update the evidence on the treatment efficacy of the Invisalign appliance.
Material and Methods: Medical databases were screened for relevant peer-reviewed articles from 2000 to 2018 for the use of Invisalign as a treatment intervention. All human studies other than case reports and case series were included.
Results: A total of 25 articles (4 RCTs, 6 prospective cohort studies, 15 retrospective cohort studies) were included. Treatment outcomes have been improving over the past 17 years. Invisalign treatment …

Mir-365 (Microrna): Potnetial Biomarker In Oral Squamous Cell Carcinoma Exosomes And Extracellular Vesicles, Jeffery Coon, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: miR-365 is a non-coding microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers, while suppressing these effects in others. Many microRNAs are produced and then exported extracellularly in exosomes, which are small extracellular vesicles ranging from 30 to 100 nm that are found in eukaryotic fluids and facilitate many cellular functions. Exosomes and extracellular vesicles are produced by many cell types, including oral cancer cells—although no study to date has evaluated miR-365 and oral cancer exosomes or extracellular vesicles. Based on this information, our research question was to evaluate whether oral cancers …

Rare A-Type, Spiro-Type, And Highly Oligomeric Proanthocyanidins From Pinus Massoniana, Bin Zhou, Yvette Alania, Mariana C. Reis, James Mcalpine, Ana K. Bedran-Russo, Guido F. Pauli, Shao-Nong Chen

School of Dentistry Faculty Research and Publications

An investigation of the dental bioactive proanthocyanidin (PAC) oligomer fractions led to three structurally distinct new PACs (1–3) from pine bark. Pinutwindoublin (1) is the first reported trimer with double A-type interflavanyl linkages (2α→O→5,4α→6 and 2α→O→7,4α→8). Pinuspirotetrin (2) represents the first reported PAC tetramer with a heterodimeric framework consisting of one spiro-type and one A-type dimer. Pinumassohexin (3) was elucidated as a mixed A + B-type hexamer that consists of a peanut-derived tetramer, peanut procyanidin E, and an A-type dimer (5). Compound 3 increased the modulus of elasticity of dentin …

Insight - Summer 2020, Dugoni School Of Dentistry

Insight

Whether you are involved in clinical research, biomedical research, the scholarship of teaching and learning, improvement of the health care system, or professional partnerships that advance the field, we aim to spotlight the work of people at the Dugoni School.

Critical Micrornas And Regulatory Motifs In Cleft Palate Identified By A Conserved Mirna-Tf-Gene Network Approach In Humans And Mice, Aimin Li, Peilin Jia, Saurav Mallik, Rong Fei, Hiroki Yoshioka, Akiko Suzuki, Junichi Iwata, Zhongming Zhao

Faculty, Staff and Student Publications

Cleft palate (CP) is the second most common congenital birth defect. The etiology of CP is complicated, with involvement of various genetic and environmental factors. To investigate the gene regulatory mechanisms, we designed a powerful regulatory analytical approach to identify the conserved regulatory networks in humans and mice, from which we identified critical microRNAs (miRNAs), target genes and regulatory motifs (miRNA-TF-gene) related to CP. Using our manually curated genes and miRNAs with evidence in CP in humans and mice, we constructed miRNA and transcription factor (TF) co-regulation networks for both humans and mice. A consensus regulatory loop (miR17/miR20a-FOXE1-PDGFRA) and eight …

Ada News - 07/13/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Plant And Fungal Products That Extend Lifespan In Caenorhabditis Elegans, Jan Martel, Cheng Yeu Wu, Hsin Hsin Peng, Yun Fei Ko, Hung Chi Yang, John D. Young, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

The nematode Caenorhabditis elegans is a useful model to study aging due to its short lifespan, ease of manipulation, and available genetic tools. Several molecules and extracts derived from plants and fungi extend the lifespan of C. elegans by modulating aging-related pathways that are conserved in more complex organisms. Modulation of aging pathways leads to activation of autophagy, mitochondrial biogenesis and expression of antioxidant and detoxifying enzymes in a manner similar to caloric restriction. Low and moderate concentrations of plant and fungal molecules usually extend lifespan, while high concentrations are detrimental, consistent with a lifespan-modulating mechanism involving hormesis. We review …

Antibacterial Efficacy Of Novel Eastern Medicine-Inspired Toothpastes Compared To Commercial Formulations, Joshua S. Goldfaden

Pacific Journal of Health

Toothpaste is an oral health care agent that dates back to the 5^th Century B.C. in East Asia. Following the conception of dentistry in the 7^th Century B.C. and the field’s subsequent growth, the embodiment of toothpaste has evolved from containing natural substances such as tea leaves to abrasive chemicals, particularly: fluoride, triclosan, and sodium lauryl sulfate (SLS). Regarding how each respective reagent functions, fluoride forms a complex with calcium ions in the teeth to prevent erosion of the protective enamel coating. This ion also disrupts metabolic activities of Streptococcus mutans (S. mutans), which are the …

Cbl Negatively Regulates Nlrp3 Inflammasome Activation Through Glut1-Dependent Glycolysis Inhibition, Hsin Chung Lin, Yu Jen Chen, Yau Huei Wei, Yu Ting Chuang, Su Heng Hsieh, Jing Yu Hsieh, Yi Lin Hsieh, David M. Ojcius, Kuo Yang Huang, I. Che Chung, Sheng Ning Yuan, Yu Sun Chang, Lih Chyang Chen

All Dugoni School of Dentistry Faculty Articles

Activation of the nod-like receptor 3 (NLRP3) inflammasomes is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Cbl plays a pivotal role in suppressing NLRP3 inflammasome activation by inhibiting Pyk2-mediated apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization. Here, we showed that Cbl dampened NLRP3 inflammasome activation by inhibiting glycolysis, as demonstrated with Cbl knockout cells and treatment with the Cbl inhibitor hydrocotarnine. We revealed that the inhibition of Cbl promoted caspase-1 cleavage and interleukin (IL)-1β secretion through a glycolysis-dependent mechanism. Inhibiting Cbl increased cellular glucose uptake, glycolytic capacity, and mitochondrial oxidative …

Tri- And Tetrameric Proanthocyanidins With Dentin Bioactivities From Pinus Massoniana, Bin Zhou, Yvette Alania, Mariana C. Reis, Rasika S. Phansalkar, Joo-Won Nam, James Mcalpine, Shao-Nong Chen, Ana K. Bedran-Russo, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Guided by dentin biomechanical bioactivity, this phytochemical study led to the elucidation of an extended set of structurally demanding proanthocyanidins (PACs). Unambiguous structure determination involved detailed spectroscopic and chemical characterization of four A-type dimers (2 and 4–6), seven trimers (10–16), and six tetramers (17–22). New outcomes confirm the feasibility of determining the absolute configuration of the catechol monomers in oligomeric PACs by one-dimensional (1D) and two-dimensional (2D) NMR. Electronic circular dichroism as well as phloroglucinolysis followed by mass spectrometry and chiral phase high-performance liquid chromatography (HPLC) analysis generated the necessary chiral reference data. In …

Dental Practice Success Vol. 7 No. 2, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Dental Practice Success Special Issue: Recovery (July 2020), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Cad/Cam Milling Versus Rapid Prototyping Surgical Guide Techniques In Dental Implant Placement, Fardos N. Rizk Prof., Marwa Sabet Prof., Hebatallah Mohammed, Adham Elghamry

Dentistry

No abstract provided.

Llusd Articulator - Volume 31, Number 1, Loma Linda University School Of Dentistry

Articulator (Dentistry)

Contents:

6 | Dean's Message
10 | Curriculum transformation continues
11 | Holli Riter appointed Chief Medical Officer
15 | Patient Layla's "jaw in a day"
17 | Just-in-time Homecoming 2020
26 | From the Class of 1970, a story of service
27 | LLUSD manages a pandemic
33 | Imaging Clinic acquires NewTom VGi EVO
35 | Lane Thomsen honored for CE contributions

The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis: A Time Course Study, Joshua Murphy

Master's Theses (2009 -)

Introduction: High-frequency vibration with low magnitude acceleration has varying effects on alveolar bone. The objectives of this study were to establish a murine model for periodontitis and to explore the best time window of this model to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature-induced experimental periodontitis. Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment (n=7); and 4) experimental periodontitis + vibration (n = 9). …