Dentistry Commons^™

Microfluidic Synthesis Of Plga/Carbon Quantum Dot Microspheres For Vascular Endothelial Growth Factor Delivery, Meisam Omidi, Mohadeseh Hashemi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide-co-glycolide) (PLGA) – carbon quantum dot microspheres were produced using microfluidic platforms. The microcapsules were fabricated in flow-focusing geometry with a biphasic flow to generate solid/oil/water (s–o–w) droplets. To avoid any damage to protein functional and structural stability during the encapsulation process, the VEGF was PEGylated. The produced microspheres were intact and highly monodisperse in size (CV < 5%). Furthermore, microspheres in a size range of 16–36 µm were achieved by adjusting the flow ratio parameter. The encapsulation efficiency, release profile, and bioactivity of the produced microparticles were also studied. The loading efficiency of PEGylated VEGF in the microparticles was varied from 51–69% and more than 90% of PEGylated VEGF was released within 28 days. Furthermore, the release of VEGF was indirectly monitored by carbon quantum dots. The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications.

Applications Of 3d Printing On Craniofacial Bone Repair, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren

School of Dentistry Faculty Research and Publications

Objectives

Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.

Data & sources

A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.

Study selection

43 …

Pain Relief Knowledge, History, And Expectations Among Emergency Dental Patients, Daniel C. Brawley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction

Dentists frequently treat and manage patients with acute dental pain. Patients often seek care to treat their pain. As a part of that treatment, it is common for providers to use both prescription and non-prescription medications in the management of the patient’s dental pain. This study focused on understanding the patient’s knowledge, history and expectations regarding prescription and non-prescription medication in the management of their dental pain.

Methods

A self-report survey was developed, using Likert-type scales, consisting of 32 items, including standardized, psychometrically-tested instruments. The survey was administered to 108 adult outpatients who reported to the West Virginia University …

Assessment Of Fracture Resistance Of Maxillary First Molars After Root Canal Preparation Using Three Different Rotary Instruments (V-Taper, Protaper, Vortex Blue): Finite Element Analysis, Mehran Malakpour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Long term success of endodontically treated teeth has been one of the most challenging aspects of the field of endodontics due to reduced fracture resistance of these teeth. Recently, researchers have heightened focus on conservative endodontics in order to sustain the tooth integrity, and reduce factors impacting the fracture resistance of endodontically treated teeth. As a result, rotary instrument manufacturers have developed files that have a minimal effect on original root canal anatomy. This study used Finite Element Analysis to investigate the dental biomechanical effect of rotary instrumentation during root canal therapy. The aim of this study is to …